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Neoplasms

Digestive System Disorders

Nervous System Diseases

Small molecule drug

Growth factors

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Disease Domain	Count

Neoplasms	3
Hemic and Lymphatic Diseases	1
Immune System Diseases	1
Infectious Diseases	1
Nervous System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	3
Growth factors	1

Top 5 Target	Count

p300-CBP transcription factors	1
FGFRs(Fibroblast growth factor receptors)	1
APP x DYRK1A x α-synuclein	1
HRAS(HRas proto-oncogene, GTPase)	1

The goal of this multicenter cross-sectional study is to investigate the prevalence of peri-implantitis in China. The main questions it aims to answer are:
What is the prevalence of peri-implantitis in China
What are the risk indicators of peri-implantitis in China
Participants will be invited to a free-of-charge clinical and radiographic examination of conventional dental implants present for over 5 years.

Start Date31 Jan 2024

Sponsor / Collaborator

Shanghai Ninth People's Hospital

[+6]

ChiCTR2400080330 / SuspendedEarly Phase 1IIT

Construction and application of exercise intervention plan for peritoneal dialysis patients with sarcopenia

Start Date29 Jan 2024

Sponsor / Collaborator

Nanchang University

NCT06209931 / RecruitingNot ApplicableIIT

Retrograde Intrarenal Surgery With Tip Flexible Pressure-controlling Ureteral Access Sheath Versus Mini Percutaneous Nephrolithotomy for the Treatment of 2-3-cm Kidney Stones

The goal of this observational study is to compare the safety and efficacy between RIRS with tip flexible pressure-controlling ureteral access sheath and mini percutaneous nephrolithotripsy（PCNL） for the treatment of 2-3-cm kidney stones.

Start Date01 Oct 2023

Sponsor / Collaborator

Nanchang University

100 Clinical Results associated with Nanchang University

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0 Patents (Medical) associated with Nanchang University

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48,712

Literatures (Medical) associated with Nanchang University

01 Dec 2025·Nano-Micro Letters

Designing Electronic Structures of Multiscale Helical Converters for Tailored Ultrabroad Electromagnetic Absorption

Article

Author: Peng, Jinbin ; Luo, Guangsheng ; Li, Xin ; Peng, Yuhui ; Che, Renchao ; Liu, Chongbo ; Lin, Jing ; Zhai, Naixin ; Hu, Ruizhe ; Feng, Zhaobo

AbstractAtomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption (EMWA) materials. However, the relationship between configuration and electromagnetic (EM) loss mechanism has remained elusive. Herein, drawing inspiration from the DNA transcription process, we report the successful synthesis of novel in situ Mn/N co-doped helical carbon nanotubes with ultrabroad EMWA capability. Theoretical calculation and EM simulation confirm that the orbital coupling and spin polarization of the Mn–N4–C configuration, along with cross polarization generated by the helical structure, endow the helical converters with enhanced EM loss. As a result, HMC-8 demonstrates outstanding EMWA performance, achieving a minimum reflection loss of −63.13 dB at an ultralow thickness of 1.29 mm. Through precise tuning of the graphite domain size, HMC-7 achieves an effective absorption bandwidth (EAB) of 6.08 GHz at 2.02 mm thickness. Furthermore, constructing macroscale gradient metamaterials enables an ultrabroadband EAB of 12.16 GHz at a thickness of only 5.00 mm, with the maximum radar cross section reduction value reaching 36.4 dB m2. This innovative approach not only advances the understanding of metal–nonmetal co-doping but also realizes broadband EMWA, thus contributing to the development of EMWA mechanisms and applications.

01 Feb 2025·Food Hydrocolloids

Improvement of rice protein functionality by electro-activation technology: Modulation of molecular and physicochemical properties

Author: Deng, Lizhen ; Liu, Chengmei ; Dai, Taotao ; McClements, David Julian ; Zhang, Wenhui ; Li, Ti ; Cui, Yanyao ; Chen, Jun ; Geng, Qin

Low solubility and poor functionality are the bottleneck problems that hinder the development of com. rice protein (RP) in the food industry.RP with high d. structure was modified by electro-activation (EA) technol. to prepare high-value protein in this study.The functionality of RP was significantly improved by EA technol. compared to pH-shifting.EA-RP50 was proved to be the most effective treatment to enhance dispersibility index of RP from 1.89% to 49.56%, emulsification from 8.88% to 18.39%, and foam formation from 65.0% to 125.7%.Conformation determination revealed that EA technol. depolymerized large aggregates, decreased particle size from 143 to 14.3 μm, increased sp. surface area from 41.7 to 343.8 m²/kg, increased surface charge from -18.2 to -35.0 mV and hydrophobicity from 1225 to 21954, reduced the content of broke disulfide bond from 11.3 to 2.7 μmol/g protein and loosened the dense structure of RP.Comprehensive anal. approved that the functional properties of RP were closely correlated with conformation changes.This study ingeniously employed EA technol. for enhancing the functionality of RP, which was conducive to use in industrial-scale manufacturing

01 Jan 2025·Journal of Colloid and Interface Science

A molybdenum sulfide based nitric oxide controlled release oral gel for rapid healing of oral mucosal ulcers

Article

Author: Cao, Shuangyuan ; Zhang, Yue ; Cheng, Haoxin ; Liu, Hongmei ; Bai, Danmeng ; Deng, Dan ; Wang, Qingqing ; Wang, Xiaolei ; Tian, Guangqi ; Zhao, Mengzhen

Oral mucosal ulcer is the most prevalent oral mucosal lesion, affecting over 25 % of general population. The current treatment regimens lack efficacy in addressing challenges such as wound bleeding, bacterial infection and inflammation on a continuous basis. Hence, a multi-functional oral gel (termed MPCST) with a long-acting duration is designed. It is based on a tannic acid-thioctic acid (TATA) supramolecular hydrogel which absorbs tissue exudate while exhibiting robust tissue adhesion properties. To form MPCST, TATA is loaded with MPCS, which are composed of polydopamine (PDA)-coated molybdenum disulfide (MoS₂) nanoflakes (MoS₂@PDA) with high photothermal conversion efficiency, nitric oxide (NO) precursor nitroprusside (SNP) and cerium oxide (CeO₂) with high reactive oxygen species (ROS) scavenging rate. Upon exposure to 808 nm near-infrared (NIR) irradiation, MPCS rapidly heats up and releases NO to promote angiogenesis, while exhibiting strong ROS scavenging, antibacterial (including oral common Streptococcus mutans), and anti-inflammatory properties. Animal experiments show that the MPCST oral gel, composed of MPCS and TATA hydrogel, exhibits superior therapeutic efficacy compared to the commonly used dexamethasone patch.

1

News (Medical) associated with Nanchang University

05 Aug 2024

·www.drugs.com

Prevalence of Overactive Bladder in U.S. Men Increased Significantly Since 2005

MONDAY, Aug. 5, 2024 -- In the United States, the prevalence of overactive bladder (OAB) among men was 14.5 percent in 2015 to 2020, reflecting a significant increase from 2005, according to a study published online July 15 in Scientific Reports . Yu Cheng, from the Jiangxi Medical College at Nanchang University in China, and colleagues examined the current prevalence and recent trends of OAB among U.S. adult men and assessed the correlations between OAB and potential risk factors using data from the National Health and Nutrition Examination Survey between 2005 and 2020. Trends in prevalence were examined from 2005 to 2008, 2009 to 2014, and 2015 to 2020. The researchers found that the overall prevalence of OAB increased slightly from 11.3 to 11.7 percent in 2005-2008 to 2009-2014 and then increased significantly to 14.5 percent in 2015-2020. Stronger increases in prevalence were seen for those who were aged 40 to 59 years, non-Hispanic White and non-Hispanic Black individuals, and those with overweight and obesity. Independent risk factors for OAB included older age, non-Hispanic Black race, lower educational level and family poverty ratio, diabetes, depression, sleep disorder, other chronic comorbidities, less intense recreational activity, poorer health condition, and unsafe food. "Future studies are needed to address OAB disparities across sociodemographic subgroups and to investigate the factors driving the rising trends in subtypes of OAB among older men, non-Hispanic White and Black, and obese men," the authors write. Abstract/Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

100 Deals associated with Nanchang University

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100 Translational Medicine associated with Nanchang University

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Pipeline

Pipeline Snapshot as of 07 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

3

1

Phase 2 Clinical

Other

2

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Recombinant bovine basic fibroblast growth factor(Nanchang University) ( FGFRs )	Stomatitis More	Phase 2
DC_CP20 ( p300-CBP transcription factors )	Leukemia More	Preclinical
compound 5a(Tanta University) ( HRAS )	Colonic Cancer More	Preclinical
(-)-Epigallocatechin Gallate ( APP x DYRK1A x α-synuclein )	Reperfusion Injury More	Preclinical
DC-630-8 ( MAGL )	Inflammation More	Discontinued