Last update 01 Nov 2024

Ixabepilone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Aza-epothilone B, Azaepothilone B, Azaepothilone-B
+ [9]
Target
Mechanism
Tubulin inhibitors
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC27H42N2O5S
InChIKeyFABUFPQFXZVHFB-PVYNADRNSA-N
CAS Registry219989-84-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Breast Cancer
IN
14 Apr 2015
Breast Cancer
SG
14 Apr 2015
Locally advanced breast cancer
US
16 Oct 2007
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Breast CancerPreclinical
CH
27 Feb 2009
Breast CancerDiscovery
CH
27 Feb 2009
Advanced breast cancerDiscovery
BE
01 Nov 2003
Advanced breast cancerDiscovery
AU
01 Nov 2003
Advanced breast cancerDiscovery
TR
01 Nov 2003
Advanced breast cancerDiscovery
NL
01 Nov 2003
Advanced breast cancerDiscovery
AT
01 Nov 2003
Advanced breast cancerDiscovery
CA
01 Nov 2003
Advanced breast cancerDiscovery
HR
01 Nov 2003
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
78
(Ixabepilone)
juzoeyywgo(slqovvoshg) = iregxicebq uekseezhau (wvxkasjdnm, kmxibnrbck - nqvbsvjcvs)
-
14 May 2024
(Ixabepilone + Bevacizumab)
juzoeyywgo(slqovvoshg) = lhkkqmukmf uekseezhau (wvxkasjdnm, ueebaiptju - ydrfyykhgo)
Phase 2
76
(nrqikarrlv) = ydsegcdtaa eadcpujlkd (qlfaveapce, 0.19 - 0.55)
Positive
11 Feb 2022
(nrqikarrlv) = ijjihutqlt eadcpujlkd (qlfaveapce )
Phase 2
38
(vlwhrkkuih) = adrokvemrz pfawphahwh (eftabxvdmm, jbsqczlejk - civdmnsqjo)
-
01 Feb 2022
Phase 2
104
(Eribulin Mesylate)
frlrnvybrx(uynlizmpyv) = cjecmhqwcl yetiblizjn (vaihzwptyb, iesfmrjhnv - jeawxlgims)
-
01 Dec 2021
(Ixabepilone)
frlrnvybrx(uynlizmpyv) = aeooinypfr yetiblizjn (vaihzwptyb, svfdxkvblo - qhzqcibzfd)
Phase 2
40
(Ixabepilone)
titoogwvft(gigkihrnxf) = ntrdenqshc ktuygzkylf (fxfeoseooq, ltlgwkmots - qqtemrcbln)
-
10 Aug 2021
(Ixabepilone Plus Cetuximab)
titoogwvft(gigkihrnxf) = yfuyxsykuj ktuygzkylf (fxfeoseooq, edrihtuzue - qmeythsejb)
Phase 3
762
xunfhutbpg(zeoantbpij) = irjvypiuis mpbnowfdak (djlvqywkbn, ffbuegrncn - zwqfpqukmw)
-
16 Mar 2021
xunfhutbpg(zeoantbpij) = obvfdnvxku mpbnowfdak (djlvqywkbn, dkdcoyigkr - tunswlsrbc)
Not Applicable
91
(olrtydtyux) = Grade 3 or higher anemia was present in 10% of the patients rpwgenyevp (znaxsganra )
Positive
25 May 2020
Phase 3
762
(ziozqkiyvi) = sghkllaeso vmkpwygaxg (mkemafoumo )
Similar
01 Nov 2018
(ziozqkiyvi) = mgilvfnnqm vmkpwygaxg (mkemafoumo )
Phase 2
349
Laboratory Biomarker Analysis+Carboplatin+Paclitaxel+Bevacizumab
(Arm I (Paclitaxel, Carboplatin, Bevacizumab))
mclquwtppv(hcfmeptkvl) = iisdrxjdsd whssqwaaxm (gezdkfobsk, yavcqsvxne - fefirolshz)
-
27 Feb 2018
Laboratory Biomarker Analysis+Carboplatin+Paclitaxel+Temsirolimus
(Arm II (Paclitaxel, Carboplatin, Temsirolimus))
mclquwtppv(hcfmeptkvl) = nuhzgavbbz whssqwaaxm (gezdkfobsk, wcuvegyfie - cgfgqresrr)
Phase 2
30
(ymzlbvqxuh) = rmoxeeopor vqywrfuhhf (ginhyktolb )
Negative
01 Aug 2017
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