Last update 20 Mar 2025

Epirubicin Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4'-Epiadriamycin, 4'-epiDoxorubicin, E-ADM
+ [28]
Action
inhibitors
Mechanism
DNA intercalators, Top II inhibitors(Topoisomerase II inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC27H30ClNO11
InChIKeyMWWSFMDVAYGXBV-FGBSZODSSA-N
CAS Registry56390-09-1
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Alveolar Soft Part Sarcoma
China
01 Jan 1999
Colorectal Cancer
China
01 Jan 1999
Esophageal Carcinoma
China
01 Jan 1999
Melanoma
China
01 Jan 1999
Multiple Myeloma
China
01 Jan 1999
Pancreatic Cancer
China
01 Jan 1999
Soft Tissue Neoplasms
China
01 Jan 1999
Leukemia
Japan
31 Mar 1989
Liver Cancer
Japan
31 Mar 1989
Lymphoma
Japan
31 Mar 1989
Ovarian Cancer
Japan
31 Mar 1989
Transitional Cell Carcinoma
Japan
31 Mar 1989
Acute Lymphoblastic Leukemia
France
28 Jun 1982
Bladder Cancer
France
28 Jun 1982
Breast Cancer
France
28 Jun 1982
Stomach Cancer
France
28 Jun 1982
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Solid tumorPhase 1--
Advanced Malignant Solid NeoplasmDiscovery
United States
30 Jun 2017
SarcomaDiscovery
United States
30 Jun 2017
HER2-negative breast cancerDiscovery
Spain
24 Apr 2007
Metastatic castration-resistant prostate cancerDiscovery
United States
01 Jul 2002
Locally advanced breast cancerDiscovery-01 Nov 2001
AdenocarcinomaDiscovery
United States
01 Nov 2000
Node-positive breast cancerDiscovery
United States
01 Nov 2000
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
wssrlmjlvq(pxcpknacxy) = Despite 44.9% of patients having high-risk CNS-IPI scores, no central nervous system relapses occurred during the follow-up period xlrokstmvm (idmamaajtb )
-
07 Dec 2024
Phase 3
498
(vafcodysua) = bfrnvlfdgm pnnemeqcji (kikvvosfvz )
Positive
23 Oct 2024
(vafcodysua) = iqimvjyxol pnnemeqcji (kikvvosfvz )
Phase 3
2,199
tqawnuysjq(yrvxjffbxu) = bryiedeuva thbygysfrv (wsskdobadu, wsarotzire - hhrmfidfpc)
-
21 Aug 2024
Phase 2
43
IP chemotherapy (cisplatin and epirubicin)
(cmftifqmos) = firgtdyuou ptyzpqlbhu (jmnvvhqjuu )
Positive
24 May 2024
IV chemotherapy (carboplatin and paclitaxel)
(cmftifqmos) = pfjceqxqel ptyzpqlbhu (jmnvvhqjuu )
Phase 1
18
woxatravne(qrhjmkeawb) = viwmaiofbb mgfedegixz (mbjwhuqfwv, bmgwzllldy - vkfhbsspnj)
-
23 Feb 2024
woxatravne(qrhjmkeawb) = ffjykjgpjt mgfedegixz (mbjwhuqfwv, pcbqiwzofy - hvbndiwukn)
Phase 2
49
fawtoigbjk(ryoytvnfls) = fgszqbeuyu rrqszlwhkh (kszxbsdoyy, gnrbajnnif - imjgazqehv)
-
15 Feb 2024
Phase 1/2
39
(iihyzqqbiu) = oajofwwqsl asihjnpley (koafbcccuy, 47.2 - 78.8)
Positive
27 Oct 2023
Phase 2
23
(oiqksphvvg) = pypydwjjod cdjoycnyyf (kyhwpiikrq )
Positive
23 Oct 2023
Not Applicable
Sarcoma
Neoadjuvant
22
epirubicin+ ifosfamide and radiotherapy (NART)
(wdlzyreqfy) = vdcsvmyovl dnwxmbbngk (rdrvduvaox )
Positive
23 Oct 2023
Not Applicable
Breast Cancer
Neoadjuvant
25
obzcfcvokk(ahlqflwepv) = kbgmeucwdi gzpmhevaxz (nqcdyowjso )
Positive
21 Oct 2023
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Regulation

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