Delving into the Latest Updates on Lamivudine/Nevirapine/Zidovudine with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

LAMIVUDINE/ZIDOVUDINE/NEVIRAPINE, Nevirapine/Zidovudine/Lamivudine, Nevirapine/lamivudine/zidovudine

+ [4]

Target

RT

Mechanism

RT inhibitors(Reverse transcriptase inhibitors)

Therapeutic Areas

Immune System DiseasesInfectious DiseasesUrogenital Diseases

Active Indication

HIV Infections

Inactive Indication-

Originator Organization

Shanghai Desano Pharmaceuticals Co. Ltd.

Active Organization

Shanghai Desino Biopharmaceutical Co., Ltd.

Inactive Organization

Micro Labs Ltd.

Drug Highest PhaseApproved

First Approval Date

CN (23 May 2018),

HIV Infections

Regulation-

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Structure/Sequence

Molecular FormulaC15H14N4O

InChIKeyNQDJXKOVJZTUJA-UHFFFAOYSA-N

CAS Registry129618-40-2

View All Structures (3)

It is unclear whether children with HIV and severe acute malnutrition can be started on highly active antiretroviral therapy (HAART) safely while they are still malnourished and the manner in which this therapy should start. This study will examine the safety, efficacy, and metabolism of children started on HAART while still severely malnourished.

Start Date01 Jul 2011

Sponsor / Collaborator

Washington University School of Medicine

NCT01469520

/ Unknown statusPhase 1

Phase I Three-way Crossover Bioequivalence Study of Pediatric Formulations of Lamivudine/Zidovudine/Nevirapine Using Healthy Adult Volunteers

The purpose of the study is to determine the bioavailability/bioequivalence of two pediatric formulations (tablet and reconstitutable suspension) of lamivudine/zidovudine/ nevirapine in comparison to an innovator product. Establishing the bioequivalence of a newly developed age-appropriate fixed dose combination of lamivudine/zidovudine/ nevirapine as an oral dispersible tablet or a reconstitutable suspension for children is invaluable for future product registration and availability of the products to children, thus filling the void in pediatric HIV/AIDS therapy.

Start Date01 Oct 2010

Sponsor / Collaborator

Elim Pediatric Pharmaceuticals Inc.

100 Clinical Results associated with Lamivudine/Nevirapine/Zidovudine

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100 Translational Medicine associated with Lamivudine/Nevirapine/Zidovudine

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100 Patents (Medical) associated with Lamivudine/Nevirapine/Zidovudine

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100 Deals associated with Lamivudine/Nevirapine/Zidovudine

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External Link

KEGG	Wiki	ATC	Drug Bank
-	-	J05AR05	-

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
HIV Infections	CN	Shanghai Desino Biopharmaceutical Co., Ltd.	23 May 2018

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


IAS2010	Not Applicable	Renal Insufficiency	62	Tenofovir/lamivudine/efavirenz	(ukswjdqmcj) = lyzwrmvezn tnvhzqnlag (qccfobgibm ) View more	-	01 Jan 2010
				Tenofovir/lamivudine/nevirapine	(ukswjdqmcj) = ivxplpknbo tnvhzqnlag (qccfobgibm ) View more
IAS2010	Not Applicable	Stevens-Johnson Syndrome	-	Combivir / Efavirenz	(pcsdrnjtmn) = Stevens-Johnsons syndrome can present in HAART experienced stable children switching to a Nevirapine based regimen, therefore extra caution should be taken when switching and close followup done to detect and promptly manage reactions. jqghtoumzv (nnipyzkykd )	-	01 Jan 2010
				Combivir / Nevirapine
IAS2008	Not Applicable	First line	-	Lamivudine-Zidovudine-Nevirapine FDC	uegokdttcy(lfogahdbij) = tazownpmqt gsegsvnjpc (silggnneuv )	-	01 Jan 2008
PHPT-3 (IAS2008)	Not Applicable	HIV Infections	-	Tenofovir + Emtricitabine + Efavirenz/Nevirapine	bdcyhiojpa(fndlgalnrd) = Renal function-related, hematological and other Serious Adverse Events occurred in 0.3%, 0.6% and 14.1% patients on tenofovir versus 0.5% (P=1.00), 10.6% (P<0.001), 13.1% (P=0.79) on zidovudine, respectively fobmmhluxf (ietbtmbmlx ) View more	-	01 Jan 2008
				Zidovudine + Lamivudine + Efavirenz/Nevirapine
IAS2007	Not Applicable	-	600	Zidovudine/Lamivudine plus ABC	davzbafnsf(asbjwwvhls) = yggdunders fihjdtgmfo (lfgwgnwklp ) View more	-	01 Jan 2007
				Zidovudine/Lamivudine plus NVP	davzbafnsf(asbjwwvhls) = axswhzjnif fihjdtgmfo (lfgwgnwklp ) View more
DART (IAS2006)	Not Applicable	-	21	Zidovudine/Lamivudine/Nevirapine	(fyagmdrhoa) = zgzxuyzwiy ogqcfsjqbh (nqfenpgkdq, 38 - 42)	-	01 Jan 2006
IAS2004	Not Applicable	-	271	Combination short-course zidovudine (ZDV) and intrapartum/neonatal nevirapine (NVP)	vvwijmrrxx(jeqgehbrts) = guonilzosb knjfzxqasw (bgzcjumtqs, 2.5% - 8.5%)	-	01 Jan 2004
IAS2001	Not Applicable	-	18	Nevirapine 400 mg/day	(noxuhtsrhp) = ylcudrjepc kpqbfkmtrr (xjhzqyoyew )	-	01 Jan 2001
				Nevirapine 600 mg/day	(noxuhtsrhp) = aouhgnxqan kpqbfkmtrr (xjhzqyoyew )