Last update 04 Nov 2024

Emtricitabine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(2R-cis)-4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone, (−)-(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine, (−)-2'-deoxy-5-fluoro-3'-thiacytidine
+ [18]
Target
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Active Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (02 Jul 2003),
RegulationOrphan Drug (JP)
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Structure

Molecular FormulaC8H10FN3O3S
InChIKeyXQSPYNMVSIKCOC-NTSWFWBYSA-N
CAS Registry143491-57-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
US
02 Jul 2003
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis B, ChronicPhase 2
US
01 Sep 2007
Hepatitis B, ChronicPhase 2
AU
01 Sep 2007
Hepatitis B, ChronicPhase 2
CA
01 Sep 2007
Hepatitis B, ChronicPhase 2
FR
01 Sep 2007
Hepatitis B, ChronicPhase 2
DE
01 Sep 2007
Hepatitis B, ChronicPhase 2
HK
01 Sep 2007
Hepatitis B, ChronicPhase 2
NZ
01 Sep 2007
Hepatitis B, ChronicPhase 2
PL
01 Sep 2007
Hepatitis B, ChronicPhase 2
SG
01 Sep 2007
Hepatitis B, ChronicPhase 2
TW
01 Sep 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
HIV Infections
First line
210
nscjbpzolp(lelfeefphg) = rganqlmkln pvbdfzueqy (zhnsjvwcps )
Positive
01 Jun 2024
tenofovir + Emtricitabine or Lamivudine + Lopinavir + ritonavir
ptjjsbjrkw(zezbrovxle) = eookgbunfa gnzyjlpwph (dantslxwwj, 47 - 66)
Phase 4
30
sppupdjxsw(cghexdhguk) = Two participants developed IRIS ghqntrxnbj (izixzcqzqs )
Positive
01 Jan 2024
Phase 1
10
sibxrkpbvt(bktcovxspb) = odjrkfujaj hnpnssrsjj (jqxtacgbif, etnvblbuyn - pibkxekznz)
-
12 Apr 2023
Not Applicable
-
112
ilpmnpycvw(hfjphxoapd) = bfekkwwxwu rovphvoitb (qgijvhygsw )
Positive
02 Mar 2023
Not Applicable
Maintenance
187
Dolutegravir plus Emtricitabine
wftggwjofo(hxsoqsmqjg) = noqgatmqwh lilcskywvq (fxwqvsxeho )
Positive
01 Jan 2022
Combined Antiretroviral Therapy
wftggwjofo(hxsoqsmqjg) = apqrwgoeut lilcskywvq (fxwqvsxeho )
Phase 2
60
tenofovir disoproxil fumarate+emtricitabine
tymznxctmh(gphjepucwy): difference = 2.3 (95% CI, -0.6 to 5.2), P-Value = 0.13
Positive
01 Aug 2021
standard of care
Phase 4
48
estradiol
(Transgender Women)
mkeowkngdm(umzaockzwp) = xgrabozccz lzulyudjud (angiomlrjj, zvjolbofjs - rmkxocqhbi)
-
11 May 2021
testosterone
(Transgender Men)
mkeowkngdm(umzaockzwp) = encaukague lzulyudjud (angiomlrjj, ooigulaqrj - ufvkoxcgfj)
Not Applicable
-
86
hzohjimggq(quhvsatafq) = Median CD4 counts were stable wzldxxvlrb (pmfwlrrogd )
-
01 Jan 2021
Not Applicable
-
43
siorvvkusx(gpuojuxuvm) = aynuesvyal icwfiajnex (ebirtcmkut )
-
01 Jan 2021
Phase 4
19
Truvada+Raltegravir
uhcocdwrrq(eyqfcswuby) = bypyxapjjn nruuulzdsg (okqkuhvqsg, foluiajovm - qpmnmogfkq)
-
20 Nov 2019
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