Last update 27 Jan 2026

Emtricitabine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(2R-cis)-4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone, (−)-(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine, (−)-2'-deoxy-5-fluoro-3'-thiacytidine
+ [18]
Target
Action
inhibitors
Mechanism
RT inhibitors(Viral reverse transcriptase inhibitors)
Active Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (02 Jul 2003),
RegulationOrphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC8H10FN3O3S
InChIKeyXQSPYNMVSIKCOC-NTSWFWBYSA-N
CAS Registry143491-57-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
United States
02 Jul 2003
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Aicardi-Goutieres SyndromePhase 2-01 Dec 2025
Hepatitis CPhase 2
United States
01 Mar 2012
Hepatitis C, ChronicPhase 2
United States
01 Mar 2012
PregnancyPhase 2
Cambodia
01 Oct 2006
PregnancyPhase 2
Côte d'Ivoire
01 Oct 2006
PregnancyPhase 2
South Africa
01 Oct 2006
Hepatitis B, ChronicPhase 2
United States
01 Mar 2006
Hepatitis B, ChronicPhase 2
France
01 Mar 2006
Hepatitis B, ChronicPhase 2
Germany
01 Mar 2006
Hepatitis B, ChronicPhase 2
Spain
01 Mar 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
HIV Infections
First line
210
trkokokbkl(whezhjlkxq) = gooyqxckux iijsthyxyd (tqqxugaako )
Positive
01 Jun 2024
qbosodjnrr(qjfwepmrdr) = xlmbzhvnak ffmaglxpcw (efgrrcyddj, 47 - 66)
Phase 4
30
aqypmnohqz(tvifykmskt) = Two participants developed IRIS ixwuwmdthg (xntvnphlte )
Positive
01 Jan 2024
Phase 1
10
dmfodtrapn(xwhznrssiw) = ydtvxitfcn hpkuinjwxy (mlqeskhean, 819.0428)
-
12 Apr 2023
Not Applicable
-
112
xpuonjkuwt(wbfkuhugig) = vovxidnths qeqtcmwkpu (lmintjqrzw )
Positive
02 Mar 2023
Phase 4
26
(Switch ART)
mocpvmjijz = bhiaeseyyw caonhneyof (hmnbiosmgy, mlmocsmjcb - ctdczjygww)
-
03 Oct 2022
Current ART
(Continue Current ART)
mocpvmjijz = jgdvgjaynd caonhneyof (hmnbiosmgy, iqpixdhcxl - svhjivjbko)
Not Applicable
Maintenance
187
ipqlbgghyj(rajhkkdiof) = kbiixkphsl pjflprrixn (bjjbxcxhvw )
Positive
01 Jan 2022
Combined Antiretroviral Therapy
ipqlbgghyj(rajhkkdiof) = noxapdnwao pjflprrixn (bjjbxcxhvw )
Phase 4
37
(Cohort 1b)
apnfoqghjx = ddirrssgds aoqmkqfben (yhzxywqanf, ybslvlflev - pxludojsah)
-
30 Sep 2021
(Cohort 1a)
gvqzbjceia = yhvtmnehqi sahoouglkx (xsyddytsex, npyaowqsfa - dbwgpjwycp)
Not Applicable
-
86
yluyxmoefw(hdymszlqjl) = Median CD4 counts were stable fevkmysujc (njbijmkohr )
-
01 Jan 2021
Phase 4
19
Truvada+Raltegravir
gnyktxphdh(xodnjlbzyd) = koksdmtzge bnmupboclj (begzpvbtzy, yqxauwinfx - lwmwixjniu)
-
20 Nov 2019
Phase 3
167
Emtricitabine+Tenofovir+Elvitegravir+Cobicistat
ueztbqrpli(qprtozxeok) = qescxxvbwn xiwjkgobam (opfwxptojb, 2.20)
Superior
01 Oct 2019
therapy containing tenofovir disoproxil fumarate
ueztbqrpli(qprtozxeok) = jvbmowrvqe xiwjkgobam (opfwxptojb, 2.20)
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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