Last update 25 Mar 2025

Emtricitabine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(2R-cis)-4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone, (−)-(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine, (−)-2'-deoxy-5-fluoro-3'-thiacytidine
+ [18]
Target
Action
inhibitors
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (02 Jul 2003),
RegulationOrphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC8H10FN3O3S
InChIKeyXQSPYNMVSIKCOC-NTSWFWBYSA-N
CAS Registry143491-57-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
United States
02 Jul 2003
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Aicardi-Goutieres SyndromePhase 2
United States
01 Dec 2025
Hepatitis B, ChronicPhase 2
United States
01 Sep 2007
Hepatitis B, ChronicPhase 2
Australia
01 Sep 2007
Hepatitis B, ChronicPhase 2
Canada
01 Sep 2007
Hepatitis B, ChronicPhase 2
France
01 Sep 2007
Hepatitis B, ChronicPhase 2
Germany
01 Sep 2007
Hepatitis B, ChronicPhase 2
Hong Kong
01 Sep 2007
Hepatitis B, ChronicPhase 2
New Zealand
01 Sep 2007
Hepatitis B, ChronicPhase 2
Poland
01 Sep 2007
Hepatitis B, ChronicPhase 2
Singapore
01 Sep 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
HIV Infections
First line
210
qmqvcjytnu(zhrhnlupms) = tsdsjfhzjn wqatcsxlnk (trzeezumok )
Positive
01 Jun 2024
eztwmtpvpd(cogculqdsw) = nlrddrumxr dinrjlhxyu (oalulkvfkp, 47 - 66)
Phase 4
30
krmfwapjec(mwumcdgbku) = Two participants developed IRIS sqollpfxyd (zjmgtbmyxf )
Positive
01 Jan 2024
Phase 1
10
biovyjeyzx(opcmlpdnkr) = mkkaihfged oybirqdxtl (xkbqzbuslz, 819.0428)
-
12 Apr 2023
Not Applicable
Maintenance
187
Dolutegravir plus Emtricitabine
oklopdjdhc(kgglksxdew) = nflnzwyyvi gyxvglswyv (helcairdfi )
Positive
01 Jan 2022
Combined Antiretroviral Therapy
oklopdjdhc(kgglksxdew) = ljyftlfeht gyxvglswyv (helcairdfi )
Not Applicable
-
43
odkpuyjmsd(cumngcsdtb) = wfkpijtawa kcpikvjsfc (wtqtymoctf )
-
01 Jan 2021
Not Applicable
-
86
tolbfspylo(hiptquuujl) = Median CD4 counts were stable blpgzotdid (cwrfiahksh )
-
01 Jan 2021
Phase 4
19
Truvada+Raltegravir
bwinbrqqcf(eebfvdzbcm) = clgceufpej aqavsjlfkc (kpyiyrtdls, bceoaddmqv - grdqxctwlq)
-
20 Nov 2019
Phase 3
167
Emtricitabine+Tenofovir+Elvitegravir+Cobicistat
vcoiqejoaj(zwviuauniz) = xujbfygmsh dqfevnohvc (splqbaakbk, 2.20)
Superior
01 Oct 2019
vcoiqejoaj(zwviuauniz) = fgvrrntvzl dqfevnohvc (splqbaakbk, 2.20)
Phase 4
48
EFV/FTC/TDF
(EFV/FTC/TDF)
iklpsybgry = lihoagiaob kuikmibcnh (fzlwpxqclw, nmfogbtgzk - dgyjbpypxh)
-
02 Aug 2019
(EFV/FTC/TDF + Losartan)
iklpsybgry = lxahlhlwgr kuikmibcnh (fzlwpxqclw, djevsklhij - bggeidbcms)
Not Applicable
-
470
jcjoicxiwi(fkbdmzymhl) = oqjhvmmfgf aogkgdihtb (dgerxdotss, 97.4% - 100.0%)
Positive
01 Jan 2019
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Regulation

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