SummaryNystatin, a minuscule molecule drug with a penchant for functioning as an ergosterol binder, engages in targeting fungal cells, blocking their growth and replication. With a longstanding history of medical use, Nystatin remains a reliable and widely recognized option for treating infections associated with the Candida species, such as Candidiasis and Vulvovaginal Candidiasis. Initially granted approval for medical use in 1955, Nystatin has since carved a path for itself as a crucially significant medication in the treatment of fungal infections, transcending time and space. Harnessing the power of ergosterol, a fundamental component of fungal cell membranes, Nystatin mercilessly disrupts the structural integrity of cells, ultimately resulting in their untimely demise. Nystatin's effectiveness stems from its remarkable specificity for ergosterol, making it a remarkably safe and efficient treatment option for patients suffering from fungal infections. |
Drug Type Small molecule drug |
Synonyms NYS, Nyotran, Nysfungin + [21] |
Target |
Action modulators |
Mechanism Ergosterol modulators(Ergosterol modulators) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date Canada (01 Jan 1955), |
Regulation- |
Molecular FormulaC47H75NO17 |
InChIKeyZDFDJJJGIRGMBE-AFARJNEBSA-N |
CAS Registry1400-61-9 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Intestinal infections | Australia | 10 Nov 1999 | |
Candidiasis | China | 01 Jan 1995 | |
Candidiasis, Vulvovaginal | China | 01 Jan 1995 | |
Mycoses | Canada | 31 Dec 1979 |
Phase 4 | 95 | qktfzxsfbk(fihdowftzb) = iktebsxrsm eztquimeqx (pzavrizjyv ) | - | 17 Apr 2020 | |||
Control (Sterile water) | qktfzxsfbk(fihdowftzb) = bumgmtqmqq eztquimeqx (pzavrizjyv ) | ||||||
Phase 3 | 160 | (Gynoclin V (Terconazole+Clindamycin+Fluocinolone Acetonide)) | wafxtykfff(rrvokdfcxm) = jyevixbjnt ltfnngciub (uqdrnmrkfz, wzzucoqtfm - tfkmrohjtz) View more | - | 24 Dec 2013 | ||
(Vagitrol V (Metronidazole+Fluocinolone Acetonide+Nystatin)) | wafxtykfff(rrvokdfcxm) = ngiftynjpq ltfnngciub (uqdrnmrkfz, ehzbtpdhaj - oucuuwyjvr) View more | ||||||
Phase 1/2 | 10 | Kidney transplant+Acyclovir+Acetaminophen+Nystatin+Sirolimus+Clotrimazole+Trimethoprim (TMP)/Sulfa (Bactrim, Septra)+Diphenhydramine+Alemtuzumab+Valgancyclovir+Methylprednisolone (or equivalent)+Tacrolimus+Pentamidine | llysgmiqcm(jvbybpxxsn) = vdzrodaxfe qfmfuvqmsp (kuxnatmxca, krsqgnsmkl - gcjjpgomrg) View more | - | 09 Jul 2012 |