SummaryNystatin, a minuscule molecule drug with a penchant for functioning as an ergosterol binder, engages in targeting fungal cells, blocking their growth and replication. With a longstanding history of medical use, Nystatin remains a reliable and widely recognized option for treating infections associated with the Candida species, such as Candidiasis and Vulvovaginal Candidiasis. Initially granted approval for medical use in 1955, Nystatin has since carved a path for itself as a crucially significant medication in the treatment of fungal infections, transcending time and space. Harnessing the power of ergosterol, a fundamental component of fungal cell membranes, Nystatin mercilessly disrupts the structural integrity of cells, ultimately resulting in their untimely demise. Nystatin's effectiveness stems from its remarkable specificity for ergosterol, making it a remarkably safe and efficient treatment option for patients suffering from fungal infections. |
Drug Type Small molecule drug |
Synonyms NYS, Nyotran, Nysfungin + [22] |
Target |
Mechanism Ergosterol modulators(Ergosterol modulators) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date CA (01 Jan 1955), |
Regulation- |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Intestinal infections | AU | 10 Nov 1999 | |
Candidiasis | CN | 01 Jan 1995 | |
Candidiasis, Vulvovaginal | CN | 01 Jan 1995 | |
Mycoses | CA | 31 Dec 1979 |
Phase 4 | 95 | lrmwihrkff(qeumvopyvv) = sshuinkyrj mltwemzkxe (imapvveznj ) | - | 17 Apr 2020 | |||
Control (Sterile water) | lrmwihrkff(qeumvopyvv) = onkibbdten mltwemzkxe (imapvveznj ) | ||||||
Phase 3 | 160 | (Gynoclin V (Terconazole+Clindamycin+Fluocinolone Acetonide)) | miihuswmfk(oslovpjypo) = wtkwxqclpv suqurqalwh (jyzvxyqrfe, qwhunqnijh - vbbpdpprwh) View more | - | 24 Dec 2013 | ||
(Vagitrol V (Metronidazole+Fluocinolone Acetonide+Nystatin)) | miihuswmfk(oslovpjypo) = jgemnhhmnk suqurqalwh (jyzvxyqrfe, hqzjznoegf - whmrjbadzv) View more | ||||||
Phase 1/2 | 10 | Kidney transplant+Acyclovir+Acetaminophen+Nystatin+Sirolimus+Clotrimazole+Trimethoprim (TMP)/Sulfa (Bactrim, Septra)+Diphenhydramine+Alemtuzumab+Valgancyclovir+Methylprednisolone (or equivalent)+Tacrolimus+Pentamidine | vunttqkhzs(tndefjthmk) = dzqepxfogr agvfyspykf (jxqksuvdmo, uxphxrybjf - ubzqeuzurx) View more | - | 09 Jul 2012 |