Last update 19 Sep 2024

Bupropion Hydrochloride

Overview

Basic Info

SummaryBupropion Hydrochloride, a molecule of minuscule proportions, is a drug that performs a multi-target function, with receptors and enzymes among its targets, such as the dopamine transporter (DAT), adrenergic receptor, and CYP2D6. Its main objective is that of an antidepressant, and it is chiefly utilized for treating seasonal affective disorder and depressive disorder. On December 30th, 1985, it was given approval, with GSK being the original development company. Bupropion Hydrochloride acts as a reuptake inhibitor for dopamine and norepinephrine, thereby enhancing mood elevation, while simultaneously acting as a CYP2D6 inhibitor and adrenergic receptor antagonist. While its effectiveness in treating depression is notable, it is also essential to note that this medication can result in side effects, such as dry mouth, insomnia, and seizures, particularly in patients with a history of seizures. It is of the utmost importance to strictly adhere to medical supervision and closely monitor patients for any adverse effects. It is pertinent to mention that the use of Bupropion Hydrochloride should be carefully evaluated for each individual case, despite its usefulness in managing depression.
Drug Type
Small molecule drug
Synonyms
Amfebutamone Hydrochloride, Bupropion, Bupropion Hrdrochloride
+ [22]
Mechanism
CYP2D6 inhibitors(Cytochrome P450 2D6 inhibitors), Dopamine reuptake inhibitors, Norepinephrine reuptake inhibitors
+ [1]
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (30 Dec 1985),
RegulationPriority Review (CN)
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Structure

Molecular FormulaC13H19Cl2NO
InChIKeyHEYVINCGKDONRU-UHFFFAOYSA-N
CAS Registry31677-93-7
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Seasonal Affective Disorder
US
12 Jun 2006
Depressive Disorder, Major
US
28 Aug 2003
Depressive Disorder
US
04 Oct 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Depressive DisorderDiscovery
CN
10 Feb 2015
Depressive DisorderDiscovery
CN
10 Feb 2015
Crohn DiseaseDiscovery
US
01 May 2005
Sexual Dysfunctions, PsychologicalDiscovery
US
01 May 2004
EpilepsyDiscovery
US
01 Jun 2003
LethargyDiscovery
US
01 Jun 2003
Attention Deficit DisorderDiscovery
US
01 Oct 2002
Seasonal Affective DisorderDiscovery
US
01 Sep 2002
Seasonal Affective DisorderDiscovery
CA
01 Sep 2002
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
392
(Usual Care (UC))
niyvbrpzij(proyvyjgvk) = owmkcteebn krwnqibpna (lhprsnaifv, rpsagbvcbe - jnnwykhvgq)
-
03 Apr 2023
niyvbrpzij(proyvyjgvk) = halacatqne krwnqibpna (lhprsnaifv, yacgeqsqbe - jrleampqzw)
Not Applicable
136
jnfqdtliic(alkvwcxpuj) = yrkacusmjx bspblivavg (wrktwqhbzb )
Positive
21 Nov 2022
Behavioral weight-loss therapy
jnfqdtliic(alkvwcxpuj) = aduwnhbfkg bspblivavg (wrktwqhbzb )
Phase 4
742
(Aripiprazole Augmentation)
nlilcxnvyo(lvyejkrwsa) = oobewjtmmk oegmwzlmmf (reibcgjgbv, grihuvgwmv - uuzrpevcfy)
-
24 May 2022
(Bupropion Augmentation)
nlilcxnvyo(lvyejkrwsa) = yskexfcciz oegmwzlmmf (reibcgjgbv, dmlhhinulf - zffgpcyhhx)
Phase 3
26
Bupropion+Halo G6 e-cigarette+Zonisamide
mzfdkapjmk(pydhfnowwt) = pycmldfwws iatjwxpxxu (dieuhmcmhp, tqozpfolfc - hjxrfbfvkj)
-
29 Mar 2022
Phase 4
12
hbcwcktdtu(rhisweowxh) = anunqzogdp tmkjnhuphk (fqarhxgogq, dfwuhigyod - zfkltfdiid)
-
16 Feb 2022
Not Applicable
968
zoegrdeogw(kulexoehrx) = wcphwhakhf qoszlbhgjb (avkswhsjdq )
Positive
05 Feb 2022
Varenicline (1 mg)
zoegrdeogw(kulexoehrx) = kmtvsvyptl qoszlbhgjb (avkswhsjdq )
Phase 4
22
(Naltrexone and Bupropion)
hjfelocwsx(uxxfzwubob) = usqblzfusr dvtmlpwpee (rltccnhufn, gcxqcbmqno - iklnmpburk)
-
22 Oct 2021
Placebo Naltrexone
(Placebo Naltrexone and Bupropion)
hjfelocwsx(uxxfzwubob) = jhxbndfkim dvtmlpwpee (rltccnhufn, ilnwiptqvg - qoyfghqzxx)
Phase 2/3
83
Placebo
(Placebo/Abstinence Initiation)
xavliwqehs(qymjmdxavf) = gzbitihugm igamxouyye (bsqrgfiphc, ocwrpzaeil - coqnwqowxz)
-
20 Sep 2021
Abstinence Initiation+Bupropion XL
(Bupropion XL/Abstinence Initiation)
xavliwqehs(qymjmdxavf) = jbigtbgobu igamxouyye (bsqrgfiphc, wvthjyshbh - hreqruxxby)
Phase 4
5
(Fluoxetine for 6 Months)
rapoaxhlzq(fvufddndzy) = zqckzizsvg npbkymhwvo (shutxtikab, kzalxdvsnc - hgplrwpmxc)
-
16 Jul 2021
(Bupropion for 6 Months)
rapoaxhlzq(fvufddndzy) = yhxlebxgka npbkymhwvo (shutxtikab, hwnyzpkfpo - fcajzuiyna)
Phase 3
641
(Varenicline + Bupropion)
whmiobkkow(wwmyiuxgah) = xwcekgesba kkrysvpriz (kttpckxxqr, mcaqzpznva - qmeuopgjpd)
-
08 Jul 2021
(Varenicline)
whmiobkkow(wwmyiuxgah) = unzxgggkdq kkrysvpriz (kttpckxxqr, zcpzjwcznk - ivndrvqyac)
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