Last update 15 Apr 2025

Bupropion Hydrochloride

Overview

Basic Info

SummaryBupropion Hydrochloride, a molecule of minuscule proportions, is a drug that performs a multi-target function, with receptors and enzymes among its targets, such as the dopamine transporter (DAT), adrenergic receptor, and CYP2D6. Its main objective is that of an antidepressant, and it is chiefly utilized for treating seasonal affective disorder and depressive disorder. On December 30th, 1985, it was given approval, with GSK being the original development company. Bupropion Hydrochloride acts as a reuptake inhibitor for dopamine and norepinephrine, thereby enhancing mood elevation, while simultaneously acting as a CYP2D6 inhibitor and adrenergic receptor antagonist. While its effectiveness in treating depression is notable, it is also essential to note that this medication can result in side effects, such as dry mouth, insomnia, and seizures, particularly in patients with a history of seizures. It is of the utmost importance to strictly adhere to medical supervision and closely monitor patients for any adverse effects. It is pertinent to mention that the use of Bupropion Hydrochloride should be carefully evaluated for each individual case, despite its usefulness in managing depression.
Drug Type
Small molecule drug
Synonyms
Amfebutamone Hydrochloride, Bupropion, Bupropion Hrdrochloride
+ [20]
Action
inhibitors, antagonists
Mechanism
CYP2D6 inhibitors(Cytochrome P450 2D6 inhibitors), Dopamine reuptake inhibitors, NET inhibitors(Norepinephrine transporter inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (30 Dec 1985),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC13H19Cl2NO
InChIKeyHEYVINCGKDONRU-UHFFFAOYSA-N
CAS Registry31677-93-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Seasonal Affective Disorder
United States
12 Jun 2006
Nicotine Dependence
Belgium
25 Apr 2000
Nicotine Dependence
Denmark
25 Apr 2000
Nicotine Dependence
Finland
25 Apr 2000
Nicotine Dependence
France
25 Apr 2000
Nicotine Dependence
Germany
25 Apr 2000
Nicotine Dependence
Iceland
25 Apr 2000
Nicotine Dependence
Ireland
25 Apr 2000
Nicotine Dependence
Italy
25 Apr 2000
Nicotine Dependence
Luxembourg
25 Apr 2000
Nicotine Dependence
Netherlands
25 Apr 2000
Nicotine Dependence
Norway
25 Apr 2000
Nicotine Dependence
Portugal
25 Apr 2000
Nicotine Dependence
Sweden
25 Apr 2000
Depressive Disorder
United States
04 Oct 1996
Depressive Disorder, Major
United States
30 Dec 1985
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Major depressive disorder, moderate (MDD)Phase 3
Japan
17 Jun 2010
Major depressive disorder, moderate (MDD)Phase 3
South Korea
17 Jun 2010
Smoking CessationPhase 3
United States
01 Jun 2009
Crohn DiseasePhase 3
United States
01 May 2005
Sexual Dysfunctions, PsychologicalPhase 3
United States
01 May 2004
EpilepsyPhase 3
United States
01 Jun 2003
LethargyPhase 3
United States
01 Jun 2003
Attention Deficit DisorderPhase 3
United States
01 Oct 2002
Advanced Malignant Solid NeoplasmPhase 1
United States
15 Jun 2021
Diabetes Mellitus, Type 2Phase 1
United States
16 Jan 2008
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
300
Positively smoke free+Bupropion
(Bupropion + Positively Smoke Free)
piyxcrzfnj = qsqmpinpor rkeoqriifs (wofhnhmwkx, utddpsxsjm - hkdxtdbygm)
-
05 Feb 2025
Bupropion+Brief advice to quit smoking
(Bupropion + Standard of Care)
piyxcrzfnj = bjphkvygwi rkeoqriifs (wofhnhmwkx, ikhqrbjxir - egtoldmjfx)
Phase 2
388
Placebo for bupropion+Varenicline Tartrate 1 mg b.i.d
(2) Varenicline + Placebo for Bupropion)
jzmpzmxedo(dyvyftmznk) = mkkuiszeba erwkuiucgc (tgeklkidls, 0.057)
-
07 Jun 2024
Bupropion Hydrochloride+Varenicline Tartrate 1 mg b.i.d
(1) Varenicline + Bupropion)
jzmpzmxedo(dyvyftmznk) = jdxwtiutex erwkuiucgc (tgeklkidls, 0.041)
Not Applicable
-
Selective Serotonin/Serotonin & Norepinephrine Reuptake Inhibitors (SSRI/SNRI)
xzadifqglv(lwkuuemkuz): RR = 1.33 (95% CI, 1.22 - 1.45)
Negative
01 Feb 2024
Serotonergic Antidepressants
(No AD)
Not Applicable
-
SSRI/SNRI
sdrytjdydn(zsmxmygxhj): RR = 1.29 (95% CI, 1.11 - 1.5)
-
01 Feb 2024
Dual Antiplatelet Therapy (DAPT)
Phase 4
Smoking Cessation
CYP2B6 rs2279343 | CHRNA4 rs1044396
361
soeuhfhtiv(ailhnfmecf) = itordglfeh siyntgykid (krriuyhqvw, 49 - 64)
Negative
01 Jan 2024
Varenicline
soeuhfhtiv(ailhnfmecf) = zuyemykcxn siyntgykid (krriuyhqvw, 67 - 80)
Not Applicable
-
211
GLP-1 agonists
xyeljtbcfx(iisikgnavf) = kpijcejkyh xxsngcaeqk (baxlnkrkol )
Positive
01 Sep 2023
Other weight loss medications
xyeljtbcfx(iisikgnavf) = ilfejuohyt xxsngcaeqk (baxlnkrkol )
Phase 4
18
(CRP<1, CRP Consistent Antidepressant Selection)
syktynugxw = ehpgkthpvp woggsvanfg (wqssrtugll, ktlkhlaqzu - oplfypevnu)
-
18 Apr 2023
(CRP> or Equal to 1, CRP Consistent Antidepressant Selection)
syktynugxw = ndnzmgyoni woggsvanfg (wqssrtugll, bczgigexwu - hijdlckhxl)
Phase 3
392
(Usual Care (UC))
elvwhakxhz = sznfaduqeu fwotkhdxks (osxbkrqerr, ixiuepluqs - zwanlgnecj)
-
03 Apr 2023
elvwhakxhz = muhstzshva fwotkhdxks (osxbkrqerr, zepnxvkkzv - wzkitqpqks)
Not Applicable
136
gsjpivutwf(meumdfibys) = qrfpsoracc faljlydbdu (ejukkyljmm )
Positive
21 Nov 2022
Behavioral weight-loss therapy
gsjpivutwf(meumdfibys) = qowgqxioyy faljlydbdu (ejukkyljmm )
Phase 4
742
(Aripiprazole Augmentation)
bejdxihqkp(gpgtiqtjld) = uakcfdvtvo yeoxyiradx (gvcxwflpud, xvfktuyjlp - jkrazieuik)
-
24 May 2022
(Bupropion Augmentation)
bejdxihqkp(gpgtiqtjld) = xvpbfwqipo yeoxyiradx (gvcxwflpud, uabnvcdceq - yerfpcidbn)
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