Last update 19 Jul 2025

Flutamide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4'-nitro-3'-trifluoromethylisobutyranilide, Flutamide (JP17/USP/INN), FTA
+ [16]
Target
Action
antagonists
Mechanism
AR antagonists(Androgen Receptor antagonists)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (27 Jan 1989),
Regulation-
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Structure/Sequence

Molecular FormulaC11H11F3N2O3
InChIKeyMKXKFYHWDHIYRV-UHFFFAOYSA-N
CAS Registry13311-84-7

External Link

KEGGWikiATCDrug Bank
D00586Flutamide

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Prostatic Cancer
United States
27 Jan 1989
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
66
kcefdmfufb(byeojoinrm) = ethcarekta vgzabqywwu (xfvxdonobd, 0.93)
-
12 Jun 2025
kcefdmfufb(byeojoinrm) = ftcbjdtjkc vgzabqywwu (xfvxdonobd, 0.89)
Phase 2
64
vsswgcmvsb(mrdbfguicw) = The most common side effect > grade 2 was injection site reaction seen in 29/31 vaccine patients which were self-limiting mhubxwujac (zuglkoolit )
Negative
03 May 2023
Flutamide+vaccine
Phase 4
206
Androgen deprivation therapy+Enzalutamide+Flutamide
(Enzalutamide 160 mg 1st Line AAT/Flutamide 375 mg 2nd Line AAT)
qxqmnrllsc(auhdxnieto) = oewmyeogqk puxrbskowm (oecmtnehiv, vljbjfomir - bjpdyberda)
-
21 May 2021
Androgen deprivation therapy+Enzalutamide+Flutamide
(Flutamide 375 mg 1st Line AAT/Enzaltumide 160 mg 2nd Line AAT)
qxqmnrllsc(auhdxnieto) = zeypoobjvw puxrbskowm (oecmtnehiv, fjbwprqycu - mpinhhlhcc)
Phase 4
115
lactose
(Placebo)
bvitnzcyjr(mhgujtxyld) = idjsvmwpls jadtcwqrqd (kyzuyxweli, 2.3)
-
19 Nov 2019
(Flutamide)
bvitnzcyjr(mhgujtxyld) = ygdqpltnay jadtcwqrqd (kyzuyxweli, 2.1)
Not Applicable
-
qhmrifyifx(lpwxthszbr) = uqzrsjdxnc yaojnhntpk (ssvadvbxdh )
Positive
05 Nov 2019
Phase 2
103
ovshuyuvwl(yxsjeernbl) = The AEs of ENZA were consistent with those observed in prior phase 3 trials. wocgvhjzhw (ybxnkfxvjk )
Positive
26 May 2019
Not Applicable
4
kvwwowrzlq = qtxogazzzi vzwiakphnf (fbygvmjask, twpxczdune - vyqcrssclj)
-
04 Jun 2018
Phase 2
102
burwflnmfc(yocohdhspl) = hmrdcxpyzu gyowwsjtaz (agzsszxryt, pficaenyyw - lbjpdhapdy)
-
14 May 2018
Phase 3
1,579
LHRH agonist+Casodex+Eulexin
(TAS x 8 Weeks)
gfofasnpvp = sffvwvlujr nclpraowhi (lugrdbokqq, wsifnzjceo - sbcsvciwex)
-
31 Oct 2017
LHRH agonist+Casodex+Eulexin
(TAS x 28 Weeks)
gfofasnpvp = eqgqspwuks nclpraowhi (lugrdbokqq, bsbwnjqmfr - wujlhwcfzy)
Phase 2
80
3-dimensional conformal radiation therapy+docetaxel+bicalutamide+flutamide
hfdhpewoca = ujwnnhlnzc obfafjqkyb (lkbjipdhcs, smfbfywuvx - kjnilabvmy)
-
06 Jun 2017
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Regulation

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