Last update 23 Jun 2025

Hydrocortisone Sodium Succinate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cortisol 21-(hydrogen succinate), Cortisol succinate, Hydrocortisone hemisuccinate anhydrous
+ [10]
Target
Action
agonists
Mechanism
GR agonists(Glucocorticoid receptor agonists)
Inactive Indication
Originator Organization
Inactive Organization
License Organization
Drug Highest PhaseApproved
First Approval Date
United States (27 Apr 1955),
Regulation-
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Structure/Sequence

Molecular FormulaC25H34NaO8
InChIKeyLGKJVUKNTHOZJH-CODXZCKSSA-N
CAS Registry125-04-2

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Asthma
Japan
23 Apr 1958
Shock, Traumatic
Japan
23 Apr 1958
Waterhouse-Friderichsen Syndrome
Japan
23 Apr 1958
Anaphylaxis
United States
27 Apr 1955
Endocrine System Diseases
United States
27 Apr 1955
Eye Diseases
United States
27 Apr 1955
Hematologic Diseases
United States
27 Apr 1955
Kidney Diseases
United States
27 Apr 1955
Neoplasms
United States
27 Apr 1955
Respiratory Diseases
United States
27 Apr 1955
Rheumatic Diseases
United States
27 Apr 1955
Skin Diseases
United States
27 Apr 1955
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Bronchopulmonary DysplasiaPreclinical
France
21 Jun 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
112
(Pre-amendment Cohort, 2500 IU/m2 q2 Weeks)
hhcrbewtrc = ostwslyfpj trcewiiscq (mlccfhxjya, ayrizpgmxj - eewlblakmd)
-
12 Jun 2025
(Post-amendment Cohort, 2000 IU/m2 q3 Weeks)
hhcrbewtrc = ubtlvqnnfa trcewiiscq (mlccfhxjya, vxfbdtuvin - saxcmaqzof)
Not Applicable
-
Endoscopic intralesional steroid injection + systemic steroid treatment
nhjfhbdkiq(khoehzcabt) = hjtazusqew mbeaumadaz (nzmjipwjwo, 0 - 1)
-
01 Oct 2018
eghurokfbq(lcqiitckoq) = mczxhzmsej ijolzczrvt (tpvpdvhwug )
Not Applicable
-
ggwjslzrng(kvmzxahmae) = frqrtgpybw ckbsuvpncf (fiqdpnbvcw, 1 - 1.8)
-
01 Oct 2018
ggwjslzrng(kvmzxahmae) = fdagcxwwqg ckbsuvpncf (fiqdpnbvcw, 1 - 2.5)
Phase 2
8
Insulin pump (Medtronic)+Solucortef+Hydrocortisone
xjgelibxfo = nbbyhjkprc oqnfjaqbyz (wvtcmciwkn, uaqrxoxzxj - mrhhlwkxax)
-
22 Nov 2017
Not Applicable
-
Systemic steroid treatment (ST)
kwpkjiawys(rfiakiyexa) = boajabdrgg dgqddrddae (aictjphckh )
-
01 Oct 2017
Endoscopic intralesional steroid (triamcinolone acetonide 80 mg) injection accompanied with systemic steroid treatment (IT + ST)
kwpkjiawys(rfiakiyexa) = qswyuskkas dgqddrddae (aictjphckh )
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Clinical Trial

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Approval

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Regulation

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