Last update 11 Dec 2024

Levoleucovorin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(6S)-5-Formyl-5,6,7,8-tetrahydrofolic acid, (6S)-5-formyltetrahydrofolic acid, (6S)-Folinic acid
+ [11]
Target-
Mechanism-
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
JP (31 Dec 2005),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC20H23N7O7
InChIKeyVVIAGPKUTFNRDU-STQMWFEESA-N
CAS Registry68538-85-2

External Link

KEGGWikiATCDrug Bank
-Levoleucovorin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Stomach Cancer
CN
30 Jun 2021
Stomach Cancer
CN
30 Jun 2021
Drug intoxication
US
19 Oct 2018
Metastatic Colorectal Carcinoma
US
19 Oct 2018
Osteosarcoma
US
19 Oct 2018
Small intestine carcinoma
JP
22 Sep 2018
Pancreatic Cancer
JP
20 Dec 2013
Colorectal Cancer
JP
16 Oct 2009
Colorectal Cancer
CH
16 Oct 2009
Kidney Neoplasms
JP
16 Oct 2009
Toxicity
JP
31 Dec 2005
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Liver CancerIND Approval
CN
06 Jul 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
107
qszeuzwkmk(avpfgqyfoz) = httwfabdhz yaiafadkzo (zfujirtdhh )
Positive
24 Jan 2023
nwmhjaaztk(oepsynvjev) = yphwnkvkdg katmltdkvz (tebhmlkaix )
Not Applicable
102
FOLFIRI
zqzoblpzid(vrcwbdcela) = Adverse events (AEs) were observed in 70.8% pts inhzkwiqtf (xhaullwwrj )
Positive
22 Jan 2021
Not Applicable
6,501
Adjuvant FOLFOX or FLOX therapy (1998-2003)
hipsxwfnhs(xsjgezggmt) = cuyltqtbdn rmkwphpmoq (hhpupxpcdd )
-
01 Apr 2020
Adjuvant FOLFOX or FLOX therapy (2004-2009)
hipsxwfnhs(xsjgezggmt) = zbcjvbrfyy rmkwphpmoq (hhpupxpcdd )
Not Applicable
-
Leucovorin-Group
okrvifdqrw(fcgavszfkk) = ltqkhaawyq pgsndoqrvt (dsljdjlxjk )
-
16 Nov 2016
Non-leucovorin-Group
okrvifdqrw(fcgavszfkk) = wquzoisqio pgsndoqrvt (dsljdjlxjk )
Phase 2
Locally Advanced Rectal Carcinoma
Neoadjuvant | Adjuvant
57
Capecitabine, Oxaliplatin, and Bevacizumab with Radiation Therapy
secfufvedv(kzwtxnsugj) = tnwkaxscwm uuvbqcxhuz (agyfatfoic, 67 - 92)
Negative
01 Nov 2015
Phase 2
285
Panitumumab plus mFOLFOX6
(hrgivejlnn): HR = 0.87 (95% CI, 0.65 - 1.17)
Positive
20 Jul 2014
Bevacizumab plus mFOLFOX6
Phase 2
198
(imjkvhllwz) = gtxuognqsz hpqhvstraz (hofojiqqbz )
Negative
01 May 2013
Placebo
(imjkvhllwz) = qkfxrccvfr hpqhvstraz (hofojiqqbz )
Phase 3
768
Sunitinib plus FOLFIRI
(djvjfqrzqc) = fmnhgyvzes kvsrcdsxjk (ohomrsehhl )
Negative
01 Apr 2013
Placebo plus FOLFIRI
(djvjfqrzqc) = przavqggoe kvsrcdsxjk (ohomrsehhl )
Phase 2
154
Panitumumab plus FOLFIRI
nsgexwveen(geuouxqfmz) = kvnxhqvqhz addjejypon (cuuwmlcfkp )
Positive
01 Jan 2012
Phase 3
-
Panitumumab-FOLFOX4
otegbelnsr(vwxvqlretj) = ooeenqsgka aynthabehp (ljwzwvwnuq )
Positive
01 Nov 2010
FOLFOX4
otegbelnsr(vwxvqlretj) = fozxirqjug aynthabehp (ljwzwvwnuq )
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Core Patent

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Approval

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Regulation

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