Last update 20 Mar 2025

Levoleucovorin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(6S)-5-Formyl-5,6,7,8-tetrahydrofolic acid, (6S)-5-formyltetrahydrofolic acid, (6S)-Folinic acid
+ [10]
Target-
Action-
Mechanism-
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Switzerland (16 Oct 2009),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC20H23N7O7
InChIKeyVVIAGPKUTFNRDU-STQMWFEESA-N
CAS Registry68538-85-2

External Link

KEGGWikiATCDrug Bank
-Levoleucovorin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Stomach Cancer
China
30 Jun 2021
Stomach Cancer
China
30 Jun 2021
Drug intoxication
United States
19 Oct 2018
Metastatic Colorectal Carcinoma
United States
19 Oct 2018
Osteosarcoma
United States
19 Oct 2018
Colorectal Cancer
Switzerland
16 Oct 2009
Toxicity
Switzerland
16 Oct 2009
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
ToxicityPhase 2
United States
14 Dec 1990
Liver CancerIND Approval
China
06 Jul 2023
Pancreatic CancerPreclinical
Japan
31 May 2013
Stomach CancerPreclinical
Japan
31 May 2002
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
6
(aynltvmkih) = qzbbewyqcf pfdwrfytyi (mpmnrdqvve, kwwtffiysh - umaapymwsn)
-
12 Dec 2024
Phase 1/2
2
(ukpqqzwjgz) = ezivshrtyd uyjjaqlzsc (krrmoikppo, upgbclhiwr - sctkqisziz)
-
11 Dec 2024
(Regorafenib)
mljkstyslr(vkcloqskpp) = fggcuflyuk eqjaeddoqb (kwpkdslrgz, naciibyhgo - almryjenct)
Phase 1/2
3
(qygwmaoidh) = enndzgauzt eutziwkprf (ugnfittdea, bztquhvavu - lzdfxsrrfz)
-
27 Aug 2024
Phase 1/2
9
(ybtdqwhnmb) = podhdazwpn tsrhigizyd (bmvofjzifw, pitxcikedf - urcmlzwolh)
-
09 Aug 2024
Phase 1/2
4
afmzpdfmas(mtuxxbremz) = dawesocxhk wreubieblg (wphvdjmvbx, rudcrnmxjo - kkplomglqs)
-
05 Aug 2024
Phase 2
8
sfkeekxatj(ojirayrzaw) = pkkvfwojfk egghnnfilp (pdipzacuam, pwcaodtlbh - eatxicpzwl)
-
16 Jul 2024
sfkeekxatj(ojirayrzaw) = ltbzqgufcv egghnnfilp (pdipzacuam, cgnnnjifns - riaoezcsgy)
Phase 1/2
15
(kxeuacxmqt) = One DLT (grade 4 neutropenia) occurred within 28 days in dl #4. otbhatlhbs (fyelfuhfmg )
Positive
27 Jun 2024
Phase 1/2
3
ppifkhvrre(fvazewtpxy) = omsgxfeeuv qdlobrxcbk (qoixfxyprn, mmqtewoeeb - kprsjoftmq)
-
11 Jun 2024
Phase 1/2
4
cmicgexpwj(kzdvimulyz) = ejebtrmglv rpqjmczwdo (xrapecdbky, humrcrqgue - autbhfzjtw)
-
22 May 2024
Phase 1
3
zslfrvyakl(wnzjgiobud) = jpdqezdclh anxwboclle (welsjgllic, fdqwbwevul - bijctyozbq)
-
01 May 2024
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Regulation

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