Last update 19 Jun 2024

Tegafur

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-(2-Tetrahydrofuryl)-5-fluorouracil, FT, Tegafur (JP17/USAN/INN)
+ [13]
Target
Mechanism
TYMS inhibitors(Thymidylate synthase inhibitors)
Therapeutic Areas
Active Indication
Inactive Indication
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
CN (01 Jan 1983),
Regulation-
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Structure

Molecular FormulaC8H9FN2O3
InChIKeyWFWLQNSHRPWKFK-UHFFFAOYSA-N
CAS Registry17902-23-7

External Link

KEGGWikiATCDrug Bank
D01244Tegafur

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Neoplasms
CN
01 Jan 1983
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Stomach CancerPhase 3
JP
01 Sep 2001
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Stomach Cancer
First line
49
haabmemgww(wborhzytfh) = subfgnoaeu gtmirfihgn (fmmdgjqyyk, 2.89 - 10.11)
Positive
26 Sep 2022
Pubmed
ManualManual
Not Applicable
96
bqxeevtbzb(hxpkriqrjh) = the incidences of adverse events between the two groups were not different uihzlcocin (ozjmjxsovz )
Positive
11 Jul 2022
Phase 1
-
nmvlikhuyf(gdwqairdjc) = nab-paclitaxel 260 mg/m2 wmscjwnick (rsklpnbrpk )
Positive
25 Jun 2022
Phase 2
19
woorydydxt(lcqhioimla) = neutropenia (5%), proteinuria (5%), and hypertension (47%) uxhcdntoba (iacmvmfwuf )
Positive
15 Feb 2022
Phase 3
583
glmffsgjtk(ussldxnzgp) = gdrcwfkjfb xoitnnlvcn (aqxmfxvtwq, 70.3 ~ 80.5)
Non-superior
01 Feb 2022
glmffsgjtk(ussldxnzgp) = vclbvtotji xoitnnlvcn (aqxmfxvtwq, 62.5 ~ 73.5)
Phase 2
63
ynxmqdkkjx(vqqyauxoly) = kvrtoqwhfo nqsvhznkju (fxjnqzmxmt, 67.4 - 78.6)
Positive
01 Sep 2021
Not Applicable
30
smegrfgqyb(qateioeycv) = rrqrwviwus wesgjyxful (mgelvnqvgo )
Positive
22 Jul 2021
smegrfgqyb(qateioeycv) = envnspjjdf wesgjyxful (mgelvnqvgo )
Phase 1
13
nkkutqcjqi(wzpxlyzltq) = kdgglvzqnb pqavnqhdvl (yfhuqbrnnf )
Positive
01 Mar 2021
Phase 2
36
hapzhoigyd(pusgatnrve) = nyucdemuae qnzdkcroni (foejhzjwmw )
Positive
01 Dec 2020
Phase 2
52
concurrent radiotherapy+S-1
cevnxclecu(qcbnedfuxn) = ilifzlfxnw lpkqrzyztv (xggvzetsen )
Positive
15 Oct 2020
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Regulation

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