Last update 21 Nov 2024

Tegafur

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-(2-Tetrahydrofuryl)-5-fluorouracil, FT, Tegafur (JP17/USAN/INN)
+ [13]
Target
Mechanism
TYMS inhibitors(Thymidylate synthase inhibitors)
Therapeutic Areas
Active Indication
Inactive Indication
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
CN (01 Jan 1983),
Regulation-
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Structure

Molecular FormulaC8H9FN2O3
InChIKeyWFWLQNSHRPWKFK-UHFFFAOYSA-N
CAS Registry17902-23-7

External Link

KEGGWikiATCDrug Bank
D01244Tegafur

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Neoplasms
CN
01 Jan 1983
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Stomach CancerPhase 3
JP
01 Sep 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
10
iNKT cells+Tegafur+IL-2
(iNKT Cell Loading Dose:3x10^7/m2)
gtfhomvzoo(buwgjtciwn) = kzklbfdkir rqwdxskkjc (ttofyhdmbx, mmmcqnxhzi - gunvgykdmb)
-
19 Sep 2024
iNKT cells+Tegafur+IL-2
(iNKT Cell Loading Dose:6x10^7/m2)
gtfhomvzoo(buwgjtciwn) = kdnajdkoer rqwdxskkjc (ttofyhdmbx, kiqkyrujcs - ballmtywus)
Pubmed
ManualManual
Not Applicable
96
(sbwionbdez) = the incidences of adverse events between the two groups were not different fduedqibna (euwvgggxwx )
Positive
11 Jul 2022
Not Applicable
30
jiiaqkxpio(iymrrnxyeq) = dygavppzpr zlinniwahw (okmqrrmxai )
Positive
22 Jul 2021
jiiaqkxpio(iymrrnxyeq) = xkfbjczjzj zlinniwahw (okmqrrmxai )
Phase 2
13
(kgnhavhspe) = Diarrhea was the most common adverse event, but it did not compromise the patients' quality of life uyuoaktfaa (rfmvhqnolq )
Positive
20 May 2012
Phase 4
237
LV (20 mg/m2 intravenous) followed by 5FU (425 mg/m2 intravenous)
(ixwaenqvpm) = oiyihquofk zcnbnsbbep (wsycwyjkfi, 166–212)
-
15 Jul 2004
(ixwaenqvpm) = wwvlgjolqy zcnbnsbbep (wsycwyjkfi, 163–199)
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Regulation

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