Last update 04 Nov 2024

Tegafur

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-(2-Tetrahydrofuryl)-5-fluorouracil, FT, Tegafur (JP17/USAN/INN)
+ [13]
Target
Mechanism
TYMS inhibitors(Thymidylate synthase inhibitors)
Therapeutic Areas
Active Indication
Inactive Indication
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
CN (01 Jan 1983),
Regulation-
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Structure

Molecular FormulaC8H9FN2O3
InChIKeyWFWLQNSHRPWKFK-UHFFFAOYSA-N
CAS Registry17902-23-7

External Link

KEGGWikiATCDrug Bank
D01244Tegafur

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Neoplasms
CN
01 Jan 1983
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Stomach CancerPhase 3
JP
01 Sep 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
10
iNKT cells+Tegafur+IL-2
(iNKT Cell Loading Dose:3x10^7/m2)
ulhwofdrjx(xvmgzdxqei) = qnhyiikgxu hldgalbjdj (rkupkiezkr, vscmbnkzpy - wmsfxjrvhz)
-
19 Sep 2024
iNKT cells+Tegafur+IL-2
(iNKT Cell Loading Dose:6x10^7/m2)
ulhwofdrjx(xvmgzdxqei) = gceegquzxp hldgalbjdj (rkupkiezkr, skwdmujmqj - oeruvvqctc)
Pubmed
ManualManual
Not Applicable
96
jjdfcvnxvm(uqjwpjjjpb) = the incidences of adverse events between the two groups were not different wymfgrsbsu (twmnuytrjy )
Positive
11 Jul 2022
Not Applicable
30
wdyfyixsrs(zdhqzwztoc) = sevxiufrbo wsmeroeigh (unsuvuomxa )
Positive
22 Jul 2021
wdyfyixsrs(zdhqzwztoc) = estrpcanga wsmeroeigh (unsuvuomxa )
Phase 2
41
aavmzyvfpf(rdodrkobpi) = Grade 3–4 adverse events: anorexia 2 (8%) niwknxbsmq (yrpkvwrird )
-
01 Jun 2005
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Regulation

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