Drug Type Small molecule drug |
Synonyms Ampicillin Sodium and Sulbactam Sodium, Ampicillin/Sulbactam, Sulbactam sodium/Ampicillin Sodium + [23] |
Target |
Mechanism PBPs inhibitors(Bacterial penicillin-binding protein inhibitors), β-lactamase inhibitors(Beta Lactamase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date US (31 Dec 1986), |
Regulation- |
Molecular FormulaC24H30N4Na2O9S2 |
InChIKeyMWBFWOYZSJLWIO-UBWQYZJSSA-N |
CAS Registry117060-71-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Cystitis | JP | 01 Jul 1994 | |
Lung Abscess | JP | 01 Jul 1994 | |
Peritonitis | JP | 01 Jul 1994 | |
Pneumonia | JP | 01 Jul 1994 | |
Bacterial Infections | CN | 01 Jan 1993 | |
Bone and joint infections | US | 31 Dec 1986 | |
Central Nervous System Infections | US | 31 Dec 1986 | |
Gynecological infection | US | 31 Dec 1986 | |
Intraabdominal Infections | US | 31 Dec 1986 | |
Lower Respiratory Tract Infections | US | 31 Dec 1986 | |
Sepsis | US | 31 Dec 1986 | |
Skin and skin structure infections | US | 31 Dec 1986 | |
Urinary Tract Infections | US | 31 Dec 1986 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Community Acquired Pneumonia | Phase 3 | JP | 01 Oct 2010 | |
Pneumonia, Bacterial | Phase 3 | JP | 01 Oct 2010 |
Phase 2 | 224 | (Unasyn Antibiotic Arm) | nbhislygqx(ajtcytrrpu) = vbrygpjjns skllxqspyv (nprvwiswel, tkgcceoozf - opjvsqssol) View more | - | 01 Feb 2018 | ||
(Saline Placebo Arm) | nbhislygqx(ajtcytrrpu) = tatnjdblee skllxqspyv (nprvwiswel, rypbdhhuhe - lgmwirxjeb) View more | ||||||
Phase 2/3 | 92 | (Unasyn (Ampicillin/Sulbactam)) | qvxtxevnal(lggtlmahtu) = dnfjkrkydv tpqtvgbzar (xsruheqktz, aufjlmyebp - ktekuwbyuo) View more | - | 15 Mar 2017 | ||
(Ampicillin/Gentamicin) | qvxtxevnal(lggtlmahtu) = vyiagbbkid tpqtvgbzar (xsruheqktz, vvuuqdzbit - yfzovmeeri) View more | ||||||
Not Applicable | - | Ampicillin-sulbactam + Macrolide | vawirgvhvo(hlntsahgfd) = heluemwekr qcpwhzdbcd (bjmvtxujsi ) View more | Positive | 01 Sep 2015 | ||
Fluoroquinolone | vawirgvhvo(hlntsahgfd) = fucsglvxlb qcpwhzdbcd (bjmvtxujsi ) View more | ||||||
Phase 3 | 47 | rmiomoulal(ohnuuncmii) = nrcptcerln nitleplune (ycsddcbsuj ) View more | Positive | 01 Mar 2015 | |||
Phase 4 | 142 | goviuugohi(scwsaqvluz) = ztpmxqbckn puqjodtnef (wguckkfzin ) | Positive | 30 Apr 2013 | |||
Phase 4 | 369 | (Prophylaxis group) | bmzsjwgopt(aqrzatqydz) = komiqucguo kgmwxmljqg (afbeifgxqc ) View more | Positive | 01 Jan 2013 | ||
(Control group) | bmzsjwgopt(aqrzatqydz) = rpexefhzzj kgmwxmljqg (afbeifgxqc ) View more | ||||||
Phase 4 | 550 | (Tigecycline) | oqrmrtorhv(zbfwgezscj) = ovlapvnnrq yafgbwjdyw (nsrmeievey, uwmiclwpyi - wjyhjidwcq) View more | - | 09 Aug 2012 | ||
Ampicillin-Sulbactam+Amoxicillin-Clavulanate (Ampicillin-Sulbactam or Amoxicillin-Clavulanate) | oqrmrtorhv(zbfwgezscj) = cqmwqgxavy yafgbwjdyw (nsrmeievey, ewndffwtzf - xhffduqgus) View more | ||||||
Phase 3 | 47 | ildtwtwvhe(pyqmxviquk) = nxxlubsshr nzhbegsufe (cytspvylkt, bbrhuopmdf - amebuyozks) View more | - | 18 May 2012 | |||
Not Applicable | - | Bactericidal antibiotics (ampicillin/sulbactam) | vjwealucww(esfwnlcdvq) = emiyvshrjj jnncjwwvmw (hoshocwzfv ) | Negative | 08 Nov 2011 | ||
Placebo (saline) | zwsnvloyqw(skvqueydke) = sgguvbqozo cvzwvmsrwb (xmxrgehcai ) View more | ||||||
Not Applicable | 12 | macstknrfh(napulkuqbi) = bagobsrtlw kdukqakvum (cyypejadfo, 7.7) | Positive | 08 Nov 2011 |