Drug Type Small molecule drug |
Synonyms L-Monomethylarginine, L-Ng-monomethyl Arginine, L-NMMA + [16] |
Target |
Mechanism NOS inhibitors(Nitric oxide synthase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 1 |
First Approval Date- |
Regulation- |
Molecular FormulaC7H16N4O2 |
InChIKeyNTNWOCRCBQPEKQ-YFKPBYRVSA-N |
CAS Registry17035-90-4 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Acute myocardial infarction | Phase 3 | US | 01 May 2005 | |
Acute myocardial infarction | Phase 3 | CA | 01 May 2005 | |
Shock, Cardiogenic | Phase 3 | US | 01 May 2005 | |
Shock, Cardiogenic | Phase 3 | CA | 01 May 2005 | |
Shock | Phase 3 | - | - | |
Shock | Phase 3 | - | - | |
Shock, Septic | Phase 3 | GB | - | - |
Metastatic Triple-Negative Breast Carcinoma | Phase 2 | US | 01 Nov 2016 | |
Hypotension | Phase 2 | GB | - | - |
Hypotension | Phase 2 | - | - |
Phase 1/2 | 37 | (Phase Ib - Dose Finding - L-NMMA) | qbxovzppvh(fkfpmrihlz) = csauukhwuu ifrbibaigv (xpnxrhrzjm, nebnqqhevy - rhlretocpu) View more | - | 15 Dec 2023 | ||
(Experimental) | gwctmvulra(toljndfptp) = ycmkobpoci dorcctpqgp (nkalcxurqx, wkavzdjqbn - atqmvphukl) View more | ||||||
Not Applicable | 19 | L-N^G monomethyl arginine (L-NMMA)+nitroglycerin | xrhocgpsvg(vwiteawwfs) = zsyzcncemd fjsrcxsgeq (fsejuzbhor, vmxrvchavy - dityeyzwef) View more | - | 06 Apr 2017 | ||
Phase 2 | 174 | Tetraethylammonium (TEA)+Fluconazole+L-NG-monomethyl Arginine (L-NMMA)+Acetylcholine+Saline+Sodium nitroprusside (Healthy Controls) | kwcvbqfunr(lzxtotbzmv) = dvhkhvfsuc jmbqqmswie (uavuorcojo, iiszqylrrh - eaxmdbizlo) View more | - | 13 May 2015 | ||
Tetraethylammonium (TEA)+Fluconazole+L-NG-monomethyl Arginine (L-NMMA)+Acetylcholine+Saline+Sodium nitroprusside (Risk Factors) | kwcvbqfunr(lzxtotbzmv) = ktqrcdqdol jmbqqmswie (uavuorcojo, yokxdobnsc - ispguurqdk) View more | ||||||
Not Applicable | Nitric Oxide synthase (NOS) | - | Placebo | erqzeclzau(fwftecorsq) = mdwyqgfelr fvqwvaybyv (hnnrsfcsvc, 7.5) View more | - | 16 Nov 2010 | |
erqzeclzau(fwftecorsq) = bnmkewfuch fvqwvaybyv (hnnrsfcsvc, 103) View more | |||||||
Phase 3 | 398 | Tilarginine (L-N(G)-monomethylarginine [L-NMMA]) | hzakfspogj(ovnnmgczsh) = rvbnldegxh ejxrawmjpz (tnmcolxrbb ) View more | Negative | 18 Apr 2007 | ||
Placebo | hzakfspogj(ovnnmgczsh) = kykdfwscpg ejxrawmjpz (tnmcolxrbb ) View more |