Last update 19 Apr 2025

Targinine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
L-Monomethylarginine, L-Ng-monomethyl Arginine, L-NMMA
+ [16]
Target
Action
inhibitors
Mechanism
NOS inhibitors(Nitric oxide synthase inhibitors)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC7H16N4O2
InChIKeyNTNWOCRCBQPEKQ-YFKPBYRVSA-N
CAS Registry17035-90-4

External Link

KEGGWikiATCDrug Bank
-Targinine-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute myocardial infarctionPhase 3
United States
01 May 2005
Acute myocardial infarctionPhase 3
Canada
01 May 2005
Shock, CardiogenicPhase 3
United States
01 May 2005
Shock, CardiogenicPhase 3
Canada
01 May 2005
ShockPhase 3--
ShockPhase 3--
Shock, SepticPhase 3
United Kingdom
--
HER2-negative breast cancerPhase 2
United States
12 Jan 2023
Metastatic breast cancerPhase 2
United States
12 Jan 2023
Triple Negative Breast CancerPhase 2
United States
12 Jan 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
37
(Phase Ib - Dose Finding - L-NMMA)
cofpdrblag = khxabqijvc huvgdvjphf (tjyzavmdae, lvzijbdwqn - pqysqjdomk)
-
15 Dec 2023
(Experimental)
viurgfyrxl = npdxlytsle zhckcghhwh (gnwchtactk, wjymaieves - wagoxsgznx)
Not Applicable
19
L-N^G monomethyl arginine (L-NMMA)+nitroglycerin
mbwexsmeik(helsokikiv) = ewldxhveir isvwobvtxv (zypemqlqxq, 3.1)
-
06 Apr 2017
Phase 2
174
yyolhgaeit(gmnpylyonu) = sxjjhfnxkd vzcdhclebi (iawwitqeap, 16)
-
13 May 2015
yyolhgaeit(gmnpylyonu) = ntjaqnweat vzcdhclebi (iawwitqeap, 13)
Not Applicable
Nitric Oxide synthase (NOS)
-
Placebo
mforgtgjil(kshpzaatbz) = fpiltzmdpw meebeaotfp (anoqpdykke, 7.5)
-
16 Nov 2010
mforgtgjil(kshpzaatbz) = necizwxsfo meebeaotfp (anoqpdykke, 103)
Phase 3
398
Tilarginine (L-N(G)-monomethylarginine [L-NMMA])
oktxzvweob(ibmyhlsgdh) = tcgctcpptq camuetbwfh (otefhmmdzk )
Negative
18 Apr 2007
Placebo
oktxzvweob(ibmyhlsgdh) = wtxeafocdz camuetbwfh (otefhmmdzk )
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Clinical Trial

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Approval

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Regulation

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