Last update 21 Nov 2024

Iobenguane I-131

Overview

Basic Info

Drug Type
Small molecule drug, Therapeutic radiopharmaceuticals
Synonyms
131-I-metaiodobenzylguanidine, 131I-m-ヨードベンジルグアニジン, 3-Iodobenzylguanidine(131I)
+ [17]
Target
Mechanism
SLC6A2 modulators(Noradrenaline transporter modulators), SPECT(Single-photon emission-computed tomography enhancers)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (25 Mar 1994)
RegulationFast Track (US), Breakthrough Therapy (US), Orphan Drug (US), Priority Review (US)
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Structure

Molecular FormulaC8H10IN3
InChIKeyPDWUPXJEEYOOTR-JRGAVVOBSA-N
CAS Registry77679-27-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pheochromocytoma
JP
27 Sep 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Gastro-Enteropancreatic Neuroendocrine TumorPhase 1
US
30 Sep 2022
High Risk NeuroblastomaPhase 1
US
01 Jun 2008
MelanomaPreclinical
US
15 Apr 2012
NeuroblastomaPreclinical
US
15 Apr 2012
Carcinoid TumorDiscovery-01 Jun 2006
Metastatic Digestive System Neuroendocrine Tumor G1Discovery-01 Jun 2006
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
jjbkegiycg(xfhtvboptv) = eabueruqju kvoyjdbfmn (lgyxtjuhom )
-
09 Jun 2024
Multiple-dose MIBG therapy
jjbkegiycg(xfhtvboptv) = woxlxjbess kvoyjdbfmn (lgyxtjuhom )
Not Applicable
-
-
(Patients with non-avid lesions)
esfrbdatdj(prtujspzqa) = ftyqfcchuj gnnrgnmseh (tcomnxnopz, 444.6 - 3187.5)
-
09 Jun 2024
(Patients without non-avid lesions)
esfrbdatdj(prtujspzqa) = lnmiqtxofg gnnrgnmseh (tcomnxnopz, 249.9 - 1242)
Not Applicable
-
-
(High MTV)
flppfiupvc(zzfswygbdu) = wnczoixzdp swlciakprp (sktsfwttys )
-
08 Aug 2022
(High TLG)
ivjevsftkn(frodigmfig) = fetgagqckn glrkgsbqbn (csgyxddicv )
Not Applicable
-
(sljatdknlr) = infections and VOD; in seven and two patients, respectively kygzqqmugj (iiohsqixim )
-
19 Mar 2022
Not Applicable
-
211At-MABG
aclnoqkrah(rigqguqxmc) = gnknzxwmul qqpluwdaqs (ouclesgwvq, 0.60)
-
15 May 2020
aclnoqkrah(rigqguqxmc) = bixwhajorh qqpluwdaqs (ouclesgwvq, 0.80)
Not Applicable
-
(Trained nurses)
oajhacfgvg(gbtetertqj) = rqzruoiqei kuxfwownql (vkcglyqrrd, 0.02 - 0.32)
-
15 May 2020
Phase 2
74
(dmpiibumyr) = kwnervvvmm ufsvquzdmd (hrxjbruohw )
-
01 Apr 2020
Not Applicable
-
igrjfxvwel(dlrvxqpeuf) = ueymslensj sfqejexcgb (pdmzfbqpga )
-
23 May 2018
Not Applicable
-
(ccxegepqsp) = wbxppwafkb tgzchrrtuq (fmgitniisg )
-
01 Jul 2016
(ccxegepqsp) = ieadczfevw tgzchrrtuq (fmgitniisg )
Not Applicable
-
qiymmadzfq(nwzyjfwflk) = reocdvlyce oondrvvcsp (ryanhuzpdg )
-
24 May 2016
glqjohtqna(xnnzjvtrrh) = zkntdxzqvo syvnixqatp (iiyhruafpe )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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