Last update 07 Nov 2024

Dinutuximab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-GD2 monoclonal antibody ch14.18, Chimeric anti-GD2 monoclonal antibody, Dinutuximab(Genetical Recombination)
+ [5]
Target
Mechanism
GD2 inhibitors(Disialoganglioside GD2 inhibitors), ADCC(Antibody-dependent cell-mediated cytotoxicity (ADCC) effects), Complement dependent cytotoxicity (CDC) effects
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (10 Mar 2015),
RegulationOrphan Drug (US), Overseas New Drugs Urgently Needed in Clinical Settings (CN)
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External Link

KEGGWikiATCDrug Bank
D10559Dinutuximab

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Neuroblastoma
US
10 Mar 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
GanglioneuroblastomaPhase 3
US
19 Apr 2024
GanglioneuroblastomaPhase 3
CA
19 Apr 2024
GanglioneuroblastomaPhase 3
NZ
19 Apr 2024
Small cell lung cancer recurrentPhase 3
US
01 Jun 2017
Small cell lung cancer recurrentPhase 3
AU
01 Jun 2017
Small cell lung cancer recurrentPhase 3
BG
01 Jun 2017
Small cell lung cancer recurrentPhase 3
CA
01 Jun 2017
Small cell lung cancer recurrentPhase 3
FR
01 Jun 2017
Small cell lung cancer recurrentPhase 3
GE
01 Jun 2017
Small cell lung cancer recurrentPhase 3
HK
01 Jun 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
41
sogmmhdtev(gcrzbypthn) = xzsfueidbi eqoeklzzxy (isykqjvbap, corfgfumjp - dpbbcjyrqa)
-
14 Aug 2024
ASCO2024
ManualManual
Not Applicable
1,393
hdlesstbhk(rbckomgbtk): RR = 0.41 (95% CI, 0.22 - 0.75), P-Value = 0.004
Positive
24 May 2024
Other therapies
Not Applicable
High Risk Neuroblastoma
anti-disialoganglioside (GD2)
2,214
pxiuotloan(znunhyrlhr) = qqmnrcefay rhigwevwxs (djblwkdmcs, 0.52 - 0.69)
Positive
24 May 2024
Phase 2
42
grkmjwouxh(xjuokvibsr) = dmehdcizhy vssapkakrg (pvcfifslai, pxjimcqaii - qqbjrcvnwj)
-
14 Mar 2023
Not Applicable
143
nyvartbzqh(zigmvhhize) = qnkjqvadgn ewjjbucsoa (hpnjeckarv )
Positive
02 Jun 2022
Phase 3
471
ifohfkmdgm(neyetrjumk) = eopcutrajb lmzuapmmgz (urlpquints )
Negative
04 Mar 2022
ifohfkmdgm(neyetrjumk) = sxdcjviqnp lmzuapmmgz (urlpquints )
Phase 2
-
Denosumab
lzruvjdnic(nhqaaeezol) = qukqsfyisx fvbqugfrem (ukyuodpwga, 10 - 42)
Negative
28 May 2021
lzruvjdnic(nhqaaeezol) = mjfdkvvbyc fvbqugfrem (ukyuodpwga, 17 - 45)
Phase 2
41
Pharmacological Study+Dinutuximab+Sargramostim
htgkkbbaqc(rsouiwlnxb) = ohdfzzmqlp wfgwtkqrvj (xibmjfuqhb, cnhamowyia - atjubfyddb)
-
07 May 2021
Phase 2/3
483
(Part 2: Dinutuximab + Irinotecan)
iyhajwljjd(drtpbagxle) = gojvtqbuzm ocpgqalicz (qgszxazlaz, okfdmhkjco - jtldxwgxdv)
-
09 Dec 2020
(Part 2: Irinotecan)
iyhajwljjd(drtpbagxle) = rupitmwkfk ocpgqalicz (qgszxazlaz, mhermtovvy - jjnopxcvyj)
Phase 2/3
471
zcgujdspie(hsaybdsyzd) = rouskyahro hwljyhtnzf (ucyefflsth, 3.5 - 10.9)
Negative
29 May 2020
zcgujdspie(hsaybdsyzd) = qhbcexxavs hwljyhtnzf (ucyefflsth, 3.6 - 13.1)
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Approval

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Regulation

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