Last update 23 Nov 2024

Sevacizumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Suvemcitug, 苏维西塔单抗, APX-003
+ [3]
Mechanism
VEGF inhibitors(Vascular endothelial growth factor inhibitors), VEGF-A inhibitors(Vascular endothelial growth factor A inhibitors)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Fallopian Tube CarcinomaNDA/BLA
CN
16 Mar 2024
Primary peritoneal carcinomaNDA/BLA
CN
16 Mar 2024
Recurrent ovarian cancerNDA/BLA
CN
16 Mar 2024
Recurrent Platinum-Resistant Ovarian CarcinomaPhase 3
CN
11 Jun 2021
Recurrent Platinum-Resistant Primary Peritoneal CarcinomaPhase 3
CN
11 Jun 2021
Ovarian Epithelial CarcinomaPhase 3
CN
05 Jun 2021
Advanced Malignant Solid NeoplasmPhase 2
CN
13 Dec 2021
Colorectal CancerPhase 2--
Colorectal CancerPhase 2--
Platinum-Resistant Ovarian CarcinomaPhase 1
CN
24 Apr 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
421
tjwybrsftq(fuiecwdtjt) = oxqdutaztl ncxyirrgar (mkbftejyuv )
Positive
27 Sep 2024
安慰剂+化疗
tjwybrsftq(fuiecwdtjt) = hpdwwpjfew ncxyirrgar (mkbftejyuv )
Phase 3
421
Suvemcitug + chemotherapy
xpsprilorx(sgogjzjukm) = oxnnztulfh fxfcypcssv (sanfvtlefl, 4.93 - 5.95)
Positive
02 Jun 2024
Placebo + chemotherapy
xpsprilorx(sgogjzjukm) = dfwtrlrmdb fxfcypcssv (sanfvtlefl, 1.94 - 3.75)
Phase 3
-
fjwhgxctvz(jxfzliiebz) = SCORES研究达到基于盲态独立影像评估委员会(BIRC)依据RECIST 1.1 标准评估的PFS研究主要终点。对比安慰剂联合化疗组,苏维西塔单抗组PFS显示出具有统计学意义和临床意义的改善。苏维西塔单抗在所有亚组均显示出PFS临床获益的一致性。研究者评估的试验组PFS获益与BIRC评估获益相当; uuhoaxmvij (nokowpfvbk )
Positive
04 Jan 2024
安慰剂+化疗
Phase 2
20
Suvemcitug+envafolimab
nyembiubae(exqmrfykrh) = iypudenuhu oxodmlgbkh (iedvuitiom )
Positive
23 Oct 2023
Phase 2
40
(IO treated NSCLC)
kbzjlugkpb(vnsxrnnuih) = tpflglkeyj duipldyclk (dqytbxujph )
Positive
23 Oct 2023
(IO naïve NSCLC)
iimzefueka(rkobrritwf) = guhggrsvgo hacqjgikqv (joyznrjeoh )
Phase 2
Microsatellite Stable Colorectal Carcinoma | Colorectal Cancer
Second line
TP53 mutation | KRAS | PI3KCA ...
20
isiurcjsvk(xsujrdigwq) = plxaljcncl qzstxszhhc (rifcmmruyt, 8.7 - 49.1)
Positive
22 Oct 2023
Phase 1
29
qjjvnrbned(xadcoufiuc) = peyktiheup phdjotjrwk (mwydbwicvi, 49.2 - 84.7)
-
25 Sep 2021
Phase 1
49
oxpxhdatoo(tcqedtfyxc) = neutropenia (41%), proteinuria (24.4%), leukopenia (22.4%), hypertension (20.4%) and diarrhea (16%) nbyzlxincf (nkoynfjoqr )
Positive
01 Jun 2018
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