An Open-Label, Multicenter, Randomized, Two Treatment, Parallel, Single-Dose, Bioequivalence Study of Test Product Ixazomib Citrate Capsule 4 mg of Natco Pharma Limited, India with Reference Product NINLARO (Ixazomib Citrate) Capsule 4 mg of Takeda Pharmaceuticals America, Inc., Lexington, MA 02421 in Adult Patients with Multiple Myeloma under Fasting Condition. - NIL

Start Date10 Jun 2026

Sponsor / Collaborator

NATCO Pharma Ltd.

[+1]

CTR20253665

/ CompletedNot Applicable

枸橼酸伊沙佐米胶囊（4mg）在患者空腹状态下的多中心、随机、开发、单次给药、两周期、双交叉生物等效性试验

[Translation] A multicenter, randomized, developmental, single-dose, two-period, double-crossover bioequivalence study of ixazomib citrate capsules (4 mg) in patients in the fasting state

按有关生物等效性试验的规定，选择Takeda Pharma A/S为持证商的枸橼酸伊沙佐米胶囊（商品名：Ninlaro(恩莱瑞)®，规格：4mg）为参比制剂，对东曜药业有限公司生产，合肥亿帆生物制药有限公司提供的受试制剂枸橼酸伊沙佐米胶囊（规格：4mg）进行空腹给药人体生物等效性试验，比较受试制剂中药物的吸收速度和吸收程度与参比制剂的差异是否在可接受的范围内，评估两种制剂在空腹给药条件下的生物等效性。

[Translation]

In accordance with relevant bioequivalence testing regulations, ixazomib citrate capsules (trade name: Ninlaro®, strength: 4 mg) manufactured by Takeda Pharma A/S were selected as the reference preparation. Fasting-administered human bioequivalence studies were conducted against the test preparation, ixazomib citrate capsules (strength: 4 mg), manufactured by Dongyao Pharmaceutical Co., Ltd. and provided by Hefei Yifan Biopharmaceutical Co., Ltd. The absorption rate and extent of the test preparation were compared with those of the reference preparation to determine whether they were within an acceptable range, and the bioequivalence of the two preparations under fasting-administered conditions was evaluated.

Start Date01 Nov 2025

Sponsor / Collaborator

Hefei Yifan Biological Pharmaceutical Co., Ltd.

CTR20253002

/ CompletedNot Applicable

枸橼酸伊沙佐米胶囊在肿瘤患者空腹状态下随机、开放、两周期、两交叉生物等效性研究

[Translation] A randomized, open-label, two-period, two-crossover bioequivalence study of ixazomib citrate capsules in cancer patients under fasting conditions

评价正大天晴药业集团股份有限公司提供的枸橼酸伊沙佐米胶囊（4mg）和Takeda Pharma A/S持证的枸橼酸伊沙佐米胶囊（恩莱瑞®）（4mg）在空腹状态下给药的人体生物等效性；观察受试制剂枸橼酸伊沙佐米胶囊（4mg，正大天晴药业集团股份有限公司）和参比制剂枸橼酸伊沙佐米胶囊（恩莱瑞®）（4mg，Takeda Pharma A/S持证）在肿瘤患者中的安全性

[Translation]

To evaluate the bioequivalence of ixazomib citrate capsules (4 mg) provided by Chia Tai Tianqing Pharmaceutical Group Co., Ltd. and ixazomib citrate capsules (Enlairui®) (4 mg) licensed by Takeda Pharma A/S when administered in the fasting state in humans; to observe the safety of the test formulation ixazomib citrate capsules (4 mg, Chia Tai Tianqing Pharmaceutical Group Co., Ltd.) and the reference formulation ixazomib citrate capsules (Enlairui®) (4 mg, licensed by Takeda Pharma A/S) in cancer patients.

Start Date13 Aug 2025

Sponsor / Collaborator

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

100 Clinical Results associated with Ixazomib citrate

100 Translational Medicine associated with Ixazomib citrate

100 Patents (Medical) associated with Ixazomib citrate

954

Literatures (Medical) associated with Ixazomib citrate

01 Sep 2026·BIOCHEMICAL PHARMACOLOGY

Nanoparticle-Based delivery of proteasome inhibitors for glioblastoma Therapy: Strategies to overcome Blood-Brain barrier and therapeutic resistance

Review

Author: Ali, Meser M ; Apu, Ehsanul Hoque ; Yadab, Mahesh Kumar ; Rahman, Md Ataur

Glioblastoma (GBM), the most malignant primary brain tumor, has a poor prognosis despite surgical resection, radiation, and temozolomide-based chemotherapy. GBM's strong infiltrativeness, intratumoral heterogeneity, activation of compensatory survival mechanisms, and the tight blood-brain barrier (BBB) prevent medication delivery to tumor regions, causing therapeutic failure. Dysregulation of the ubiquitin-proteasome system (UPS), which regulates proteostasis, apoptosis, cell cycle progression, and stress responses, contributes to glioblastoma progression and therapeutic resistance. Thus, proteasome inhibitors (PIs) such bortezomib (BTZ), carfilzomib, ixazomib, and marizomib are promising treatments. However, low BBB penetration, systemic toxicity, and drug resistance mechanisms have hampered its GBM clinical usefulness. Nanoparticle-based therapeutic delivery technologies improve drug solubility, pharmacokinetics, and brain tumor targeting to address these issues. Liposomes, polymeric nanoparticles, dendrimers, inorganic nanoparticles, and exosome-derived vesicles can improve PI bioavailability and treatment efficacy in preclinical GBM models. Surface functionalization with targeted ligands, peptides, and antibodies improves BBB transport and tumor uptake. Stimuli-responsive nanocarriers and multi-modal nanoparticle systems allow regulated drug release and combinatorial delivery of chemotherapeutics, genetic materials, and radiosensitizers. To improve glioblastoma clinical outcomes with nanomedicine and proteasome inhibition, we also explore translational difficulties and prospects. This review provides the UPS's biological role in GBM, proteasome inhibitors and their limitations, and nanoparticle-enabled delivery techniques to bypass BBB barriers and treatment resistance.

01 Aug 2026·Clinical Lymphoma Myeloma & Leukemia

Ixazomib, Cyclophosphamide, and Dexamethasone (ICd), With or Without Daratumumab in Relapsed Multiple Myeloma

Article

Author: Dingli, David ; Hobbs, Miriam ; Dispenzieri, Angela ; Rajkumar, S Vincent ; Warsame, Rahma ; Sher, Taimur ; Buadi, Francis ; Kumar, Shaji ; Gertz, Morie ; Asmus, Erik ; Bergsagel, Leif ; Roy, Vivek ; Kapoor, Prashant ; Hayman, Suzanne ; Knopf, Betsy ; Christenson, Lisa ; Ailawadhi, Sikander ; Fonder, Amie ; Gonsalves, Wilson ; Siddiqi, Mustaqeem ; Fonseca, Rafael ; Kourelis, Taxiarchis

BACKGROUND:

Proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies form the backbone of initial treatment for myeloma and play an important role in the treatment of relapsed disease. However, global access to many novel therapies is limited and alkylating agents remain relevant in certain clinical settings. Ixazomib is an oral PI that enables development of all oral regimens.

PATIENTS:

We designed this open-label, multi-arm phase 2 study to evaluate the safety and efficacy of weekly oral ixazomib in various combinations for patients with relapsed MM. Herein, we discuss the results of Arms D (ixazomib, cyclophosphamide, and dexamethasone-ICd, n=33) and E (Daratumumab-ICd, n=24) that examined the ixazomib and dexamethasone in combination with cyclophosphamide or cyclophosphamide and daratumumab, respectively.

RESULTS:

The overall response rate was 73% and 75% and ≥VGPR rate was 45% and 54% in the Arms D and E, respectively. After the median follow-up of 27 months for Arm D and 41 months for Arm E, the median progression free survival was 27.1 months (95% confidence interval [CI]: 17.8-38.6) and 37.7 months (95% CI: 17.9-NA) for the arms D and E, respectively. The median overall survival was not reached for either arm. A grade 3 or higher hematological adverse event considered at least possibly related, occurred in approximately 75% of patients.

CONCLUSIONS:

The results of this phase 2 trial demonstrate clinically meaningful efficacy of ICd (±) daratumumab in the relapsed setting, with the indirect comparison suggesting a deeper response and longer PFS with adding daratumumab.

01 Aug 2026·Molecular Oncology

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Article

Author: Koji Ando ; Hirofumi Hasuda ; Aahana Tiku ; Yuho Ebata ; Siddhartha Pulukuri ; Ajit Bharti ; Allison Berger ; Elizabeth C. Unan ; Tomoharu Yoshizumi ; Koshi Mimori ; Eiji Oki

Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge. We previously showed that camptothecin induces ubiquitin–proteasome pathway (UPP)‐mediated topoI degradation. In this study, we investigated whether inhibition of UPP could prevent topoI degradation and restore camptothecin sensitivity. SN‐38, an active metabolite of irinotecan, induced topoI degradation in irinotecan‐resistant colorectal cancer cell lines, which was suppressed by ixazomib. The combination significantly enhanced cytotoxicity, colony inhibition, and reduced IC 50 values compared with SN‐38 alone. Mechanistically, ixazomib prevented proteasome‐mediated degradation of ubiquitinated topoI, restoring its stability. In vivo, the combination significantly suppressed tumor growth in a DLD‐1 xenograft model compared with SN‐38 alone. These findings indicate that UPP‐dependent topoI degradation is a key mechanism underlying irinotecan resistance in colorectal cancer. Pharmacological inhibition of the proteasome effectively prevents topoI loss and restores irinotecan sensitivity, suggesting that proteasome inhibitors such as ixazomib may serve as promising therapeutic partners for camptothecin‐based chemotherapy.

News (Medical) associated with Ixazomib citrate

08 Sep 2026

·www.biospace.com

Flare Therapeutics Appoints Peter Lebowitz, MD, PhD, to Board of Directors and Brian DeSchuytner as Chief Financial Officer and Chief Business Officer

- Addition of industry leader Dr. Peter Lebowitz strengthens the Board with deep oncology-focused drug development expertise - Brian DeSchuytner brings finance, business development, strategy, commercial and operations expertise to support company growth following prioritization of prostate cancer programs CAMBRIDGE, Mass., Sept. 08, 2026 (GLOBE NEWSWIRE) -- Flare Therapeutics Inc. (FlareTx), a clinical-stage biotechnology company targeting transcription factors to discover and develop transformative therapies for prostate cancer, today announced the appointments of Peter Lebowitz, MD, PhD, to its Board of Directors and Brian DeSchuytner as Chief Financial Officer and Chief Business Officer. “We're excited to welcome Peter to our Board. He is a highly accomplished, world-class oncology drug developer and industry leader, with a track record of identifying and delivering transformational medicines and building highly productive teams. His expertise will be invaluable as we work to advance our AR(ON) degrader, FX-111, and our AR(ON) RIPTAC program to address the needs of patients living with prostate cancer,” said Anna Protopapas, Chief Executive Officer. "We're also thrilled to have Brian join Flare Therapeutics at this pivotal moment in our growth. His broad executive leadership experience across finance, business development, strategy, commercial and operations is well-suited to advance our financial and business strategy toward key value-creating milestones.” ezstandalone.cmd.push(function () { ezstandalone.showAds(131); }); Appointment of Peter Lebowitz, MD, PhD, to Board of Directors Peter Lebowitz, MD, PhD, is Chief Executive Officer and Chief Medical Officer at Third Arc Bio. Prior to Third Arc Bio, Peter served as the Global Head of Oncology R&D for Johnson & Johnson (J&J) overseeing an end-to-end research and development organization that delivered 13 new drugs to market with over 60 approvals. Over his career, Peter has delivered multiple first and best-in-class transformational medicines, including ZYTIGA ® , IMBRUVICA ® , DARZALEX ® , DARZALEX FASPRO ® , ERLEADA ® , RYBREVANT ® , LAZCLUZE ® , CARVYKTI ® , TECVAYLI ® , TALVEY ® , TAFINLAR ® , and MEKINIST ® . Peter’s innovative approach to drug development resulted in 12 FDA Breakthrough Therapy Designations and 38 New England Journal of Medicine publications for J&J medicines. These achievements underscore his ability to push the boundaries of science and deliver life-changing therapies to patients. Prior to J&J, Peter also held multiple leadership roles at GlaxoSmithKline (GSK) including Vice President, Global Head of Oncology Early Clinical Development and Vice President and Medical Development Leader in Late Development. In these roles, he successfully filed 10 Investigational New Drug applications and played a leading role in taking two medicines from early discovery through global registration trials by setting a new benchmark with a “novel-novel” drug combination approach. Peter now also serves as a CEO partner at Omega Funds, a leading life science investment firm, and as a board director at Neomorph and BridgeBio Oncology Therapeutics. After earning his BA in chemistry from Harvard University, Peter earned his MD and PhD in cell and molecular biology from the University of Pennsylvania and completed his training in internal medicine and oncology at Duke University and the National Cancer Institute. "FlareTx’s AR(ON)-targeting degrader, FX-111, and AR(ON) RIPTAC are highly differentiated and have the potential to address key limitations of current prostate cancer therapies," said Dr. Lebowitz. “I am greatly impressed with the rigor and strength of the scientific evidence, and I am excited to join the Board and support the team as they advance these programs.” Appointment of Brian DeSchuytner as Chief Financial Officer and Chief Business Officer ezstandalone.cmd.push(function () { ezstandalone.showAds(132); }); Most recently, Mr. DeSchuytner was the Chief Financial Officer and Chief Operating Officer at Mersana Therapeutics, where he raised significant capital and led impactful business development collaborations with J&J, GSK, and Merck KGaA, culminating in the sale of the company to Day One Biopharmaceuticals. Prior to Mersana, he was Vice President responsible for ZEJULA ® (niraparib) commercialization at TESARO. Previously, Mr. DeSchuytner held increasingly senior roles in corporate development and in commercial at Millennium: The Takeda Oncology Company including serving as a Vice President and Global Brand Head responsible for the global launch of NINLARO ® (ixazomib). He started his career in the life sciences practice of L.E.K. Consulting. He holds an MBA from the Wharton School at the University of Pennsylvania and a BA from Dartmouth College. "Despite the introduction of novel androgen receptor pathway inhibitors and new targeted therapies, prostate cancer is a devastating disease and metastatic prostate cancer remains incurable. Targeting AR(ON) offers the potential to overcome key vulnerabilities of conventional therapies that target AR(OFF) and has broad potential across prostate cancer at all stages,” said Mr. DeSchuytner. “I look forward to partnering with Anna and the rest of the Flare Therapeutics team to demonstrate the value of our molecules and improve outcomes for patients living with prostate cancer.” Daphne Karydas, who served as President and Chief Financial Officer since October 2021, has decided to pursue other opportunities. Ms. Karydas will serve as an advisor to the Company, to support a smooth transition. “On behalf of the Board of Directors, our leadership and the entire Flare Therapeutics team, I also want to thank Daphne for her many contributions,” continued Ms. Protopapas. “Daphne was instrumental in growing and scaling the company to where we are today, including securing significant financing and executing key strategic partnerships. We wish her all the best in her new role.” ezstandalone.cmd.push(function () { ezstandalone.showAds(133); }); About Flare Therapeutics Inc. Flare Therapeutics is a clinical-stage biotechnology company drugging transcription factors to fully unlock the therapeutic potential of this previously elusive target class. The company’s discovery platform has generated a rich development portfolio which is currently focused on advancing transformative AR(ON)-targeting therapies for prostate cancer. For more information, please visit and follow us on LinkedIn . Contacts: Investors Sarah McCabe investorrelations@flaretx.com Media media@flaretx.com ezstandalone.cmd.push(function () { ezstandalone.showAds(134); });

Executive ChangeBreakthrough Therapy

31 Aug 2026

·www.fiercepharma.com

Takeda bolsters blood cancer portfolio with FDA nod for Mimrylo in polycythemia vera

The FDA has approved Takeda’s Mimrylo (rusfertide) for polycythemia vera, introducing a new mechanism of action to the nonmalignant rare blood cancer and handing CEO Julie Kim another major regulatory win since taking the helm. A form of myeloproliferative neoplasm, polycythemia vera (PV) causes the bone marrow to make too many red blood cells, which can result in life-threatening cardiovascular events, such as stroke and heart attack. Mimrylo offers a new approach to curtailing the overproduction of red blood cells; it’s the first drug for PV that mimics hepcidin, a hormone that naturally regulates iron in the body. By limiting the iron being released into the bloodstream, Mimrylo essentially starves excess production of new red blood cells. To keep the hematocrit level—the percentage of red blood cells in one’s blood—below the safe threshold of 45%, existing first-line treatment for PV includes withdrawing blood (known as phlebotomy), hydroxyurea and interferons, and Incyte’s JAK inhibitor, Jakafi, is also available as a second-line option. “People living with polycythemia vera have long faced the challenge of managing a chronic blood disorder with frequent blood draws to help address the consequences of the red blood cell overproduction,” Tanya Wroblewski, M.D., director of the division of nonmalignant hematology within the FDA’s Center for Drug Evaluation and Research, said in an Aug. 28 statement. “Today’s approval of Mimrylo offers a new, first-in-class option that has the potential to meaningfully reduce patient burden.” PV affects approximately 90,000 people in the U.S., and roughly 78% of patients don’t have hematocrit level under control with existing standard treatment, according to Takeda. Mimrylo proved its worth in the phase 3 Verify study. The double-blind trial enrolled 293 patients with uncontrolled hematocrit and randomized them to receive either a once-weekly subcutaneous injection of Mimrylo or placebo over 32 weeks. Between weeks 20 and 32 of the study, significantly more patients in the Mimrylo group improved to become not eligible for phlebotomy compared with those who took placebo. The percentages were 76.9% and 32.9%, respectively. Besides hematocrit control, Mimrylo patients also saw a reduction in the number of phlebotomy sessions and statistically significant improvement in fatigue compared with placebo. The drug was generally well-tolerated, as the most common treatment-emergent adverse events for the drug were injection site reactions and anemia. The trial is continuing into an open-label portion, which covers weeks 32 to 52 of treatment. Mimrylo marks the second FDA new drug approval that Takeda has secured since CEO Julie Kim officially took the reins in June 2026. In another first-in-class nod, the company’s orexin type 2 receptor agonist Orzeyful earned an FDA green light for narcolepsy type 1 earlier this month.\ “The approval of Mimrylo underscores the strength of Takeda’s late-stage pipeline and our focus on developing genuinely differentiated therapies for patients who are urgently waiting for new options,” Kim said in an Aug. 28 statement. “We are at an important inflection point as we prepare to deliver three new medicines, which have the potential to drive our future growth and are a reflection of our commitment to advancing innovation that doesn’t just add to the treatment landscape, but reshapes it.” The third new product Kim mentioned is the oral TYK 2 inhibitor zasocitinib , a potential competitor to Bristol Myers Squibb’s Sotyktu. Takeda is aiming to launch the drug in the U.S. for psoriasis in the first half of 2027. The Japanese pharma hopes the three new drugs could help it shake off some generic erosion to its top line. With Mimrylo’s launch, Takeda plans to draw on its existing expertise in hematology. The company already boasts a strong portfolio in blood disorders, including multiple myeloma drugs Velcade and Ninlaro, leukemia med Iclusig and Pfizer-partnered antibody-drug conjugate Adcetris. During Takeda’s recent earnings call in July, Kim flagged “a sense of inertia” among doctors in their treatment of PV, as they view the patients as “good cancer patients.” “So it’s a lot of education we need to do to help shine a light on the burden that PV patients have,” she said. Mimrylo was originally developed by Protagonist Therapeutics. Takeda paid the biotech $300 million upfront in 2024 to gain certain rights to the drug before buying its partner out earlier this year. The Japanese pharma now holds sole responsibility for commercializing Mimrylo globally. Before Friday’s approval, Jefferies analysts projected Mimrylo peak sales at roughly $2 billion. The content above comes from the network. if any infringement, please contact us to modify.

Clinical ResultDrug ApprovalAcquisition

15 Jul 2026

·allsci.com

SHY Therapeutics begins first-in-human trial of novel 19S proteasome inhibitor SHY-ONC6

New York-based biotech SHY Therapeutics has initiated a Phase I first-in-human (FIH) trial of SHY-ONC6, a novel proteasome inhibitor targeting the 19S regulatory particle of the 26S proteasome, in patients with advanced or metastatic solid tumors. The multicenter study, registered as NCT07705334, enrolled its first patient on June 29, 2026, and is recruiting at sites in Denver, Houston, and San Antonio. The asset represents a mechanistic departure from approved proteasome inhibitors, which target the 20S catalytic core rather than the 19S regulatory particle. The Phase I study consists of two parts: a dose-escalation phase (Phase Ia) using accelerated titration and a Bayesian optimal interval design to identify the maximum tolerated dose, followed by a dose-expansion phase (Phase Ib) in disease-specific cohorts. SHY-ONC6 is administered orally once daily in 21-day cycles. The trial plans to enroll approximately 30 patients aged 18 years or older with advanced or metastatic solid tumors—including triple-negative breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, non-small cell lung cancer, mesothelioma, pancreatic cancer, prostate cancer, and soft tissue sarcoma—whose disease has progressed on, or who are intolerant to, standard therapies. Primary endpoints include determination of the maximum tolerated dose and recommended Phase II dose, as well as assessments of dose-limiting toxicities and adverse events. Secondary endpoints include objective response rate, duration of response, progression-free survival, overall survival, and pharmacokinetic parameters such as area under the plasma concentration-time curve, maximum plasma concentration, and elimination half-life. The trial is expected to complete in May 2028. Proteasome inhibition is an established therapeutic strategy in oncology, particularly for hematologic malignancies. Approved proteasome inhibitors—including bortezomib (Velcade), carfilzomib (Kyprolis), and ixazomib (Ninlaro)—target the 20S catalytic core of the 26S proteasome, preventing the degradation of ubiquitinated proteins. The resulting accumulation of damaged and misfolded proteins triggers proteotoxic stress and apoptosis in cancer cells, particularly multiple myeloma and certain lymphomas, which are highly dependent on the proteasome to maintain protein homeostasis. While these agents have transformed treatment for blood cancers, their activity in solid tumors has been more limited due to a combination of biological resistance and dose-limiting toxicities. SHY-ONC6 takes a different approach by targeting the 19S regulatory particle, which sits upstream of the 20S catalytic core and is responsible for recognizing, unfolding, and delivering ubiquitinated proteins for degradation. The drug selectively inhibits AAA+ ATPase subunits within the 19S complex, aiming to disrupt proteasome function at an earlier stage than existing therapies. Researchers have proposed that targeting the 19S regulatory particle could overcome some mechanisms of resistance to 20S inhibitors and produce a distinct anti-tumor profile, although this approach remains experimental and has yet to be validated in clinical studies. The company has not disclosed any partnerships or external funding related to the SHY-ONC6 program. This article was generated with AI assistance and reviewed and edited by the AllSci editorial team Explore more at AllSci News: https://allsci.com/news/ Your email address will not be published. Required fields are marked * Comment * Name * Email * Website Privacy Terms About Us Copyright © 2026. AllSci Corp. All rights reserved.

Phase 1

100 Deals associated with Ixazomib citrate

External Link

KEGG	Wiki	ATC	Drug Bank
D10131	Ixazomib citrate	L01XX50	DB09570

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Multiple Myeloma	United States	Takeda Pharmaceuticals U.S.A., Inc.	20 Nov 2015

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Plasmacytoma	Phase 3	United States	Millennium Pharmaceuticals, Inc.	29 Nov 2016
Spondylocarpotarsal Synostosis	Phase 3	United States	Haupt Pharma Amareg GmbH	17 Mar 2015
Spondylocarpotarsal Synostosis	Phase 3	United States	Millennium Pharmaceuticals, Inc.	17 Mar 2015
Spondylocarpotarsal Synostosis	Phase 3	United States	Takeda Pharmaceutical (China) Co. Ltd.	17 Mar 2015
Spondylocarpotarsal Synostosis	Phase 3	Japan	Millennium Pharmaceuticals, Inc.	17 Mar 2015
Spondylocarpotarsal Synostosis	Phase 3	Japan	Takeda Pharmaceutical (China) Co. Ltd.	17 Mar 2015
Spondylocarpotarsal Synostosis	Phase 3	Japan	Haupt Pharma Amareg GmbH	17 Mar 2015
Spondylocarpotarsal Synostosis	Phase 3	Argentina	Millennium Pharmaceuticals, Inc.	17 Mar 2015
Spondylocarpotarsal Synostosis	Phase 3	Argentina	Haupt Pharma Amareg GmbH	17 Mar 2015
Spondylocarpotarsal Synostosis	Phase 3	Argentina	Takeda Pharmaceutical (China) Co. Ltd.	17 Mar 2015

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


PrE0404 (Pubmed \| Clin Lymphoma Myeloma Leuk)	Phase 1/2	Mantle cell lymphoma refractory	35	Ibrutinib 560 mgIxazomib 4 mg mg + Ibrutinib 560 mgIxazomib 4 mg	wsmiraebot(llomyqotqe) = menmognoai wkxsesoltn (tmaaqiuvje ) View more	Negative	01 Jul 2026
NCT02516423 (CTgov)	Phase 3	Plasmacytoma	11	Lenalidomide+ixazomib+zoledronic acid+dexamethasone (Ixazomib + Lenalidomide + Dexamethasone + Zoledronic Acid)	rhqpkvdelp = dqhsctqzof uicvksmzsv (zyyhubqdli, iqbklwuuld - fhyaymcsiq) View more	-	30 Jun 2026
				zoledronic acid (Zoledronic Acid)	rhqpkvdelp = iohzxscayx uicvksmzsv (zyyhubqdli, xjibxtepaz - ycxlsgahlc) View more
NCT05722405 (MPACT, EHA2026)	Phase 2	Multiple Myeloma Maintenance	41	IXAZOMIB + REDUCED-DOSE LENALIDOMIDE	zcwclpeemu(bkantahegr) = emyhoejzit erzzcjxvri (kkeeoguhes, 18.2 - 53.8)	Positive	12 May 2026
				IXAZOMIB	zcwclpeemu(bkantahegr) = yfyinzikpg erzzcjxvri (kkeeoguhes, 10.7 - 27.3)
EHA2026	Not Applicable	Multiple Myeloma First line	12,905	IXAZOMIB-based triplet regimens	gektjqswrn(ljyjqlnhca) = jnzlllzrxg csqmquyimq (wscvjxdwfl, 5.6 - 13.1) View more	Positive	12 May 2026
				BORTEZOMIB-based triplet regimens	gektjqswrn(ljyjqlnhca) = qpfmefrwuc csqmquyimq (wscvjxdwfl, 3.7 - 11.2) View more
EHA2026	Phase 2	Multiple Myeloma	20	Dara-based induction	vptoarophv(vgkeoueyey) = uswmnvqeqx evwlaxshup (dauwycovvp, 85.2 - 100) View more	Positive	12 May 2026
EHA2026	Not Applicable	Multiple Myeloma	113	Ixazomib-based regimens	svekhyvtle(mhkidefuuj) = Among those switching due to intolerance (n=17), 10/17 (58.8%) continued therapy, with no discontinuations attributed to adverse events ivifnnqznl (zbkkwxnild )	Positive	12 May 2026
				Ixazomib-based regimens (High-risk)
EHA2026	Not Applicable	Multiple Myeloma Maintenance	47	Ixazomib-based maintenance	xoywnwjeyd(ujwwbubbqh) = The most common adverse events were hematologic toxicities (neutropenia: 11%, grade 3: 0%; thrombocytopenia: 4%, grade 3: 2%; anemia: 40%, grade 3: 0%), gastrointestinal events (diarrhea: 6.4%, grade 3: 2.1%; nausea: 2.1%, grade 3: 0%), rash (2.1%, grade 3), fatigue (2.1%, grade 2), upper respiratory tract infection (2.1%, grade 2), heart failure (2.1%, grade 2), and peripheral neuropathy (4.3%, grade 2). No treatment discontinuations due to adverse events were reported. wknlbzwmff (aaqoqgwekv )	Positive	12 May 2026
EHA2026	Not Applicable	Relapse multiple myeloma	24	Ixazomib, lenalidomide, and dexamethasone (IRd) (3 prior lines)	wlwyfjcfic(gpriwlsjnv) = hskbwcfius nthhqqkeqq (yfljlkdavc )	Positive	12 May 2026
				Ixazomib, lenalidomide, and dexamethasone (IRd) (4-6 prior lines)	wlwyfjcfic(gpriwlsjnv) = dzzxagcgse nthhqqkeqq (yfljlkdavc )
EHA2026	Not Applicable	Refractory Multiple Myeloma	152	IXAZOMIB-LENALIDOMIDE-DEXAMETHASONE	zaymsphnvs(xfdbhsskrt) = ulcrbbxqrf llehvsenud (ydhbkqaayg ) View more	Positive	12 May 2026
				DARATUMUMAB-LENALIDOMIDE-DEXAMETHASONE	gawnwfksid(vntkupydfv) = dkxjmtuumk nkewxibuxw (mmdbhjjnvu )
NCT03547700 (CTgov)	Phase 1/2	Peripheral T-Cell Lymphoma \| T-cell lymphoma recurrent	11	Romidepsin+Ixazomib (All Subjects Treated)	tvoycqgeok = wmowiwogku bmvizkrzff (cwipuudrtx, qbfdedunlu - vzlrxcmxqr)	-	06 May 2026
				Romidepsin+Ixazomib (Phase I Dose Level 4:Romidepsin 10mg/m² IV on Days 1, 8, 15; Ixazomib 4 mg PO on Days 1, 8, 15)	ujbyhyeeel(ptzvjfjayf) = thoxrbhavy tdfdxaqqza (fhvgbvqunx, gnsimiaqfp - jddaaavkab) View more

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Clinical Trial

Identify the latest clinical trials across global registries.

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Approval

Accelerate your research with the latest regulatory approval information.

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Regulation

Understand key drug designations in just a few clicks with Synapse.

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Synapse data is now integrated into the PatSnap LS Model Context Protocol (MCP) service. Customize your LLM agent now using our MCP server!

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis