Delving into the Latest Updates on Epinephrine/Lidocaine Hydrochloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

EPINEPHRINE BITARTRATE/LIDOCAINE HYDROCHLORIDE, Iontocaine, Lidocaton

+ [3]

Target

SCNA x adrenergic receptor

Action

blockers, agonists

Mechanism

SCNA blockers(Sodium voltage-gated channel alpha subunits blockers), adrenergic receptor agonists(Adrenergic receptors agonists)

Therapeutic Areas

Other Diseases

Active Indication

Anesthesia

Inactive Indication

DermatophilosisPainVisible Lesion

Originator Organization

Fresenius Kabi AG

Active Organization

Fresenius Kabi USA LLCHakusui Trading Co. Ltd.

Nipro Corp.

+ [1]

Inactive Organization

Vyteris, Inc.

Dentsply Sirona, Inc.

Empi, Inc.

License Organization-

Drug Highest PhaseApproved

First Approval Date

United States (19 Nov 1948),

Anesthesia

Regulation-

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Structure/Sequence

Molecular FormulaC14H23ClN2O

InChIKeyIYBQHJMYDGVZRY-UHFFFAOYSA-N

CAS Registry73-78-9

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To investigate the feasibility of the lateral infraclavicular plexus brachialis (LIC) block for acute closed reduction of distal radius fractures, the investigators will compare the pain-relieving and muscle-relaxing properties of the LIC block with short- and long-acting local anesthetics in different concentrations but at the same volume. In addition to motor and sensory blockade during repositioning, feasibility will also be assessed by other patient-related and block-related factors, as well as by factors related to the repositioning and plastering procedure.

Start Date23 Apr 2024

Sponsor / Collaborator-

100 Clinical Results associated with Epinephrine/Lidocaine Hydrochloride

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100 Translational Medicine associated with Epinephrine/Lidocaine Hydrochloride

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100 Patents (Medical) associated with Epinephrine/Lidocaine Hydrochloride

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7

Literatures (Medical) associated with Epinephrine/Lidocaine Hydrochloride

01 Feb 2022·Hand Surgery and RehabilitationQ4 · MEDICINE

Benefits of WALANT in palliative upper limb surgery after nerve injury

Q4 · MEDICINE

Article

Author: Dukan, R ; Masmejean, E H ; Gregory, T ; Coudane, H

Wide-Awake Local Anesthesia No Tourniquet (WALANT) may be a satisfactory anesthesia alternative for the management of upper limb peripheral nerve palsy sequelae. The main advantages are the possibility of active patient cooperation through intraoperative active mobilization, comfort and cost reduction. The legislation about WALANT in France remains unclear; the modalities of lidocaine epinephrine injection should be redefined. For palliative upper limb surgery, WALANT allows the surgeon to adjust the tension on the tendon transfer intraoperatively. Level 1 studies are needed to evaluate the effectiveness of WALANT relative to standard anesthesia techniques (regional/general anesthesia).

24 Sep 2020·NeuroRehabilitationQ4 · MEDICINE

Effect of lidocaine iontophoresis combined with exercise intervention on gait and spasticity in children with spastic hemiplegic cerebral palsy: A randomized controlled trial

Q4 · MEDICINE

Article

Author: Salem, Yasser T. ; Hegazy, Fatma A. ; Aboelnasr, Emad A.

BACKGROUND: Gait deviations and spasticity are common impairments seen in children with cerebral palsy (CP) and may interfere with functional performance and effective walking pattern. Lidocaine iontophoresis is effective for reducing muscle spasticity in adults. PURPOSE: To investigate the effect of lidocaine epinephrine iontophoresis combined with exercises on gait and spasticity in children with spastic hemiplegic cerebral palsy (HCP). METHODS: Thirty children with spastic HCP aged 4–6 (5.20±0.32) years were randomly assigned to the experimental group (n = 15) and control group (n = 15). Children in both groups received one hour of exercises, three times a week for three months. Children in the experimental group received 2% lidocaine iontophoresis immediately before the exercises. The lidocaine iontophoresis was delivered for 20 minutes (1mA/min). Spatio-temporal gait parameters were assessed within one week before and after the intervention using 3D motion analysis. Surface electromyography was used to assess muscle tone using H/M ratio of the soleus muscle. ANOVA was used to investigate the differences between experimental and control groups. Statistical significance was set at P value less than 0.05. RESULTS: There was no difference between groups at baseline. Post-intervention, the experimental group showed significant improvements when compared to the control group for gait speed (p = 0.03), stride length (p = 0.04), cadence (p = 0.0001), cycle time (p = 0.0001), and H/M ratio (p = 0.02). CONCLUSION: Lidocaine iontophoresis combined with exercises was effective in improving gait spatiotemporal parameters and reducing spasticity in children with CP.

01 Sep 1990·Journal of PeriodontologyQ2 · MEDICINE

Effects of Anesthetics Containing Epinephrine on Catecholamine Levels During Periodontal Surgery

Q2 · MEDICINE

Article

Author: Concetta F. Bonura ; Robert E. Davenport ; Paul N. Baer ; Vincent J. Iacono ; George I. Mallis ; Robert J. Porcelli

Nine stable cardiovascular disease patients were evaluated in a double‐blind crossover trial during periodontal surgery using 2% lidocaine with epinephrine 1:100,000 or lidocaine alone. In the lidocaine with epinephrine group, epinephrine levels increased from 198 ±54 pg/ml to 592±166 pg/ml at 2 minutes post‐injection. In the lidocaine alone group, epinephrine levels increased from a baseline of 115±34 pg/ml to 150±34 pg/ml at 2 minutes post‐injection. Despite these elevations in epinephrine, no significant changes in heart rate or mean arterial pressure were noted. Plain lidocaine provided unsatisfactory levels of hemostasis and/or anesthesia during periodontal surgery. This study documents acute elevations in plasma epinephrine levels following local dental anesthesia for periodontal surgery. These elevations in plasma epinephrine failed to produce a significant cardiovascular response in a group of stable cardiovascular disease patients. This suggests that the cardiac effects of local anesthetics containing epinephrine are small and that they can be safely used in stable cardiovascular disease patients. J Periodontol 1990; 61:553–558.

100 Deals associated with Epinephrine/Lidocaine Hydrochloride

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External Link

KEGG	Wiki	ATC	Drug Bank
-	Epinephrine/Lidocaine Hydrochloride	N01BB52 S01EA51	-

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Anesthesia	United States	Fresenius Kabi USA LLC	19 Nov 1948

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01981772 (CTgov)	Not Applicable	Tumescence	88	4% buffered lidocaine (Buffered Lidocaine)	vwtjkqsblg(nrjapzlkch) = gnwxwhkahf jywsskvnbj (zkbfkrgrwt, fzdpulqcwa - syyuybpmuy) View more	-	12 Oct 2020
				1:100,000 epinephrine+4% lidocaine (Nonbuffered Lidocaine)	vwtjkqsblg(nrjapzlkch) = rtkpetehnn jywsskvnbj (zkbfkrgrwt, dyryimbliz - jzzxkssizn) View more
NCT03119181 (ADEPT, CTgov)	Phase 2	-	40	Iontophoresis System+lidocaine/epinephrine solution (Active Tymbion Iontophoresis)	(xrijvxqipe) = zklfvsmmov jswfmcoxqh (njtqxiaksn, awzhpbpfvq - pledtzqhpy) View more	-	06 Jan 2020
				Tymbion Lidocaine/epinephrine solution (Sham Tymbion Iontophoresis)	(xrijvxqipe) = dmrkrhpobp jswfmcoxqh (njtqxiaksn, fdbunfxokp - hrpnquvkji) View more
NCT02285634 (CTgov)	Not Applicable	Epistaxis	68	Oxymetazoline 0.05% (Oxymetazoline 0.05%)	dvaahypabn(tswpohlwij) = auukvvsgcs rjrnwkbrrw (bbmecsethi, qpufwxtpkm - ifrzntzlsa) View more	-	02 Oct 2018
				Phenylephrine 0.25% (Phenylephrine 0.25%)	dvaahypabn(tswpohlwij) = ktguebsqap rjrnwkbrrw (bbmecsethi, rapglzxkip - unsflkdszg) View more
NCT02007434 (CTgov)	Phase 3	Localized obesity	84	Cold Compress+Deoxycholic Acid Injection (Paradigm 1 / Deoxycholic Acid Injection)	oxzfcbnhwf(autlbytghk) = fsiffbumds kothzmsbup (myxdoqljay, quuueelrii - nzwcnvqhhn) View more	-	03 Jul 2015
				Cold Compress+Lidocaine / Epinephrine+Deoxycholic Acid Injection (Paradigm 2 / Deoxycholic Acid Injection)	oxzfcbnhwf(autlbytghk) = bsgwleyknj kothzmsbup (myxdoqljay, ynmlkmdhgs - ztygcvkjdm) View more