Request Demo

Last update 22 May 2026

Lidocaine Hydrochloride

Last update 22 May 2026

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Lidocaine HCI, Lidocaine hydrochloride (JAN/USP), Lidocaine Hydrochloride and Glucose

+ [18]

Target

SCNA

Action

blockers

Mechanism

SCNA blockers(Sodium voltage-gated channel alpha subunits blockers)

Therapeutic Areas

Nervous System DiseasesCardiovascular DiseasesOther Diseases

Active Indication

PainVentricular ArrhythmiaTachycardia, Ventricular+ [1]

Inactive Indication

Acute PainCatheter site discomfortUterine Cervical Cancer

Originator Organization

Fresenius Kabi AG

Active Organization

Alico Pharmaceutical

B. Braun Medical, Inc.

Powder Pharmaceuticals, Inc.

+ [6]

Inactive Organization

Lee's Pharmaceutical Holdings Ltd.

Zhaoke Pharmaceutical (Hefei) Co., Ltd.AstraZeneca LP

+ [1]

License Organization

Laboratoires Théa SAS

Anesiva, Inc.

Akorn, Inc.

+ [1]

Drug Highest PhaseApproved

First Approval Date

United States (19 Nov 1948),

Anesthesia

RegulationPriority Review (China)

Structure/Sequence

Molecular FormulaC14H25ClN2O2

InChIKeyYECIFGHRMFEPJK-UHFFFAOYSA-N

CAS Registry6108-05-0

277

Clinical Trials associated with Lidocaine Hydrochloride

NCT07054801

/ Not yet recruitingPhase 2IIT

Intra-arterial Lidocaine and Methylprednisolone Injection Into the Middle Meningeal Artery For Treatment of Headache Associated With Subarachnoid Hemorrhage

Subarachnoid hemorrhage (SAH) is a type of bleeding around the brain that can cause sudden and severe headaches. These headaches can be debilitating and persist for weeks, significantly impacting a patient's comfort and recovery. Many patients require opioids for pain control, which can lead to side effects such as drowsiness, constipation, and dependency. There is a need for new treatment strategies to help relieve this pain while minimizing side effects.
This clinical study is designed to evaluate whether an injection of two medications (lidocaine and methylprednisolone) directly into the middle meningeal artery (MMA) can help reduce headache severity in patients who recently experienced a SAH. The medications will be given through a minimally invasive procedure performed during a routine angiogram, a type of imaging test already commonly used in SAH patients. The main goals of the study are to determine whether this treatment approach is safe, helps to reduce the severity of headaches, and decreases the need for opioid pain medications. Eligible patients will be those recently diagnosed with persistent headache symptoms and SAH who are undergoing routine cerebral angiogram, during which the medications are infused into the MMA. Participants will be monitored for pain levels using the Headache Impact Test (HIT-6) and for changes in their functional recovery using standard neurologic scales. The results of this study may provide early evidence to support new treatment options for patients suffering from difficult-to-control headaches after a SAH.

Start Date01 Sep 2026

Sponsor / Collaborator

The University of California, San Francisco

NCT07224711

/ Not yet recruitingPhase 4IIT

The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery (IMPALA ERAS)

The goal of this single-center, pragmatic, randomized, blinded, placebo-controlled trial is to evaluate the impact of intravenous (IV) lidocaine within the existing Enhanced Recovery After Surgery (ERAS)program on outcomes in patients after major non-cardiac surgery. The main questions the trial aims to answer are:
The primary hypothesis is that utilization of IV lidocaine as part of a perioperative multimodal pain regimen will result in a reduction in hospital Case Mix Index-Adjusted Resource Length of Stay (CARLOS).
The secondary hypotheses are that lidocaine infusion will result in a reduction in total inpatient opioid consumption (oral morphine milligram equivalents, oMMEs) and pain scores, and improved surgical outcomes (including return of bowel function, ileus, nausea, rapid responses called, surgical site infections, and ICU transfers), while also having minimal incidence of side effects (including double/blurry vision, tinnitus, sedation, and adverse events requiring early cessation).

Start Date01 Jul 2026

Sponsor / Collaborator

Vanderbilt University Medical Center

NCT07487246

/ Not yet recruitingPhase 2

Effects of Paracervical Block With Combined Ketorolac and Lidocaine on Perceived Pain in Osmotic Dilator Placement for Abortion, a Randomized Controlled Trial

The purpose of this study is to improve pain management for participantswho need osmotic dilators for cervical preparation the day before their second trimester abortion procedure. Osmotic dilators are sticks that are inserted into the cervix. They soak up fluid and expand overnight, gently opening the cervix. We are studying an injection of ketorolac (a liquid anti-inflammatory medication similar to ibuprofen) combined with lidocaine (a liquid numbing medication), which is injected vaginally to the area surrounding the cervix. Ketorolac is approved by the U.S. Food and Drug Administration (FDA) for intravenous (IV) and intramuscular injection and has been studied as a paracervical injection for participants having first trimester abortion procedures in the office. It has not previously been studied for osmotic dilator insertion.

Start Date01 May 2026

Sponsor / Collaborator

Rush University Medical Center

100 Clinical Results associated with Lidocaine Hydrochloride

100 Translational Medicine associated with Lidocaine Hydrochloride

100 Patents (Medical) associated with Lidocaine Hydrochloride

12,618

Literatures (Medical) associated with Lidocaine Hydrochloride

03 Apr 2026·JOURNAL OF APPLIED ANIMAL WELFARE SCIENCE

Effects of a Multimodal Pain Control Protocol Using 2% Lidocaine Intradermal and Meloxicam Intramuscular on Mitigating Behavioral Castration Pain in Piglets Using a Needleless System

Article

Author: Trindade, Pedro Henrique Esteves ; Stephen, Gabriella-Louise ; Pairis-Garcia, Monique Danielle ; Merenda, Victoria Rocha ; King-Podzaline, Erin Elizabeth ; Bokhart, Alexandria

Mitigating piglet castration pain is critical to minimize negative experiences and contribute to a positive affective state. A multimodal pain control protocol (needleless 2% lidocaine intradermal/0.4 mg/kg meloxicam intramuscular) was evaluated. Males were administered one of four treatments: (1) needleless lidocaine/meloxicam intramuscular (LM), (2) needleless lidocaine/saline intramuscular (LS), (3) needleless saline/meloxicam intramuscular (SM), and (4) needleless saline/saline intramuscular (SS). Females were sham castrated (SH). Piglets were recorded 24h pre-castration (M1) and 15min (M2), 3h (M3), and 24h post-castration (M4). The Unesp-Botucatu Composite Acute Pain Scale (UPAPS) was used to assess pain behavior. From a treatment standpoint, scores did not differ at M1 (P = 1.00) or M4 (P ≥ 0.36). However, at M2, LS piglets had (P < 0.01) higher scores (3.4) than LM piglets (1.6) and SH piglets had (P ≤ 0.01) the lowest scores (0.02). From a timepoint standpoint, piglets in the LS, LM, SM, and SS groups had (P ≤ 0.05) higher scores at M2 compared with their baseline scores at M1. These results indicate that needleless lidocaine and intramuscular meloxicam offered no analgesic benefit.

01 Apr 2026·iScience

An implantable dual-chamber capsule with three release modes for site-specific delivery and enhanced therapeutic efficacy

Article

Author: Kou, Enhe ; Ren, Limin ; Tan, Yisong ; Zhang, Wenqiang ; Ren, Liwei ; Li, Shixun ; Tong, Xunwei

Precise and flexible drug delivery is increasingly required in clinical therapy, yet most implantable systems remain constrained by limited selectivity, low loading capacity, and bulky size. Here, we present an implantable capsule that employs magnetically actuated vibration of an internal metallic cantilever to achieve magnetically controlled release. The capsule integrates a dual-reservoir structure, enabling the device to load two drugs and support multimodal release through three independent modes. Experimental evaluation demonstrates a drug retention rate of 76% and a single release volume of 0.01 mL with fluctuations within ±0.0005 mL, while maintaining a miniature form factor (13 × 5 × 5 mm³) and stable performance under thermal (45 °C) and mechanical (50 g) stress. In vivo studies further confirm that insulin and lidocaine hydrochloride delivered by this capsule achieve therapeutic outcomes comparable to subcutaneous injection. Combining compactness, robustness, and multi-mode controllability, this system supports long-term implantable drug administration.

26 Jan 2026·Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology

In Vitro Effects of Liquid Cardiac Drugs on Human Catalase Enzyme.

Article

Author: Argan, Onur ; Çıkrıkcı, Kübra ; Gençer, Nahit

OBJECTIVE:

When liquid medications are administered intravenously, the first cellular defense encountered by the drug is erythrocytes. Catalase is the main antioxidant system in erythrocytes. Drug-related catalase inhibition can cause adverse effects. Although catalase is a well-known enzyme, studies investigating drug-catalase interactions are scarce in the literature. Therefore, we investigated the impact of liquid cardiac drugs on human erythrocyte catalase activity in vitro.

METHOD:

Catalase activity was determined by a spectrophotometric method using a procedure developed by Aebi. Liquid cardiac drugs were incubated with human blood in vitro. IC50 values were compared among the drugs.

RESULTS:

The most potent inhibitors were noradrenaline (IC50: 4.61 µM), adrenaline (IC50: 32.58 µM), and amiodarone hydrochloride (IC50: 41.86). Dopamine hydrochloride (IC50: 429.15 µM) and lidocaine hydrochloride (IC50: 453.1 µM) showed less inhibitory effects on catalase activity compared with adenosine (IC50: 58.49 µM), atropine sulfate (IC50: 68.75 µM), dobutamine hydrochloride (IC50: 80.79 µM), glyceryl trinitrate (IC50: 86.66 µM), and heparin sodium (IC50: 92.4 µM).

CONCLUSION:

Noradrenaline, adrenaline, and amiodarone hydrochloride have strong inhibitory effects on catalase activity. Catalase inhibition may be responsible for the side effects of these drugs. Therefore, when these drugs are used in treatment, their dosages and duration of administration should be carefully controlled to prevent adverse effects due to catalase enzyme inhibition.

News (Medical) associated with Lidocaine Hydrochloride

14 May 2026

·www.fiercepharma.com

Sun recalls US chemotherapy batch, citing glass particle contamination concerns

Administering an intravenous drug that contains glass particles could have serious health consequences, and the issue has triggered a number of other product pulls and regulatory wrist slaps in recent years. Generics juggernaut Sun Pharma is pulling one lot of a chemotherapy drug in the United States as the issue of particulate contamination crops up once again on the FDA’s recall register. Sun’s voluntary recall concerns a single batch containing 675 vials of the chemotherapy doxorubicin hydrochloride liposome injection, which is used to treat ovarian cancer, Kaposi sarcoma and multiple myeloma, according to a notice posted on the FDA’s website. The Mumbai-based company is yanking the batch after the discovery of “glass particles in some vials during production.” Administering an intravenous drug that contains the particulates could have serious health consequences, though Sun noted in its May 13 recall notice that it hasn’t received any adverse event reports linked to the suspect lot.Aside from the potential for local irritation and swelling from the presence of foreign material, intravenous injection of glass particles can, in more serious circumstances, block blood vessels and lead to life-threatening clotting, according to Sun’s release. Sun did not provide details on the cause of its glass particle problem, though the company stressed that it has “thoroughly investigated the source” and taken “corrective and preventative actions” in response to the issue. The doxorubicin vials in the affected batch were slated to expire at the end of next May. Glass particles have prompted several recalls over the years, including in Oct. 2023, when Pfizer’s Hospira unit yanked certain sodium bicarbonate and lidocaine HCI injectables over the possible presence of minute bits of glass in product vials. Earlier that same year, GSK recalled two batches of its asthma drug Nucala in Taiwan after glass particles were found in a vial of the drug. GSK had learned of the issue after receiving a complaint from a hospital in Taiwan about the presence of glass particles in one reconstituted vial of the medication. Meanwhile, India’s Zydus in 2024 received an FDA warning letter at its Waghodia plant in Gujarat in part because the company failed to properly root out the source of cross-contamination incidents, including with glass particulates in batches of a product used to treat and prevent a lack of vitamin B12.

12 Sep 2024

·pharma.economictimes.indiatimes.com

Aurobindo Pharma's subsidiary Eugia Steriles secures US FDA first product approval for Lidocaine Hydrochloride Injection

Hyderabad: Aurobindo Pharma announced that its has received first product approval from the US Food and Drug Administration ( FDA ) for ‘ Lidocaine Hydrochloride Injection , US Pharmacopeia ( USP ), 1 per cent (10 mg/mL) and 2 per cent (20 mg/mL). In a regulatory filing the drug developer informed, "The Andhra Pradesh based, new injectable facility of Eugia Steriles Private Limited (a 100 per cent subsidiary of Eugia Pharma Specialities Limited and a step down subsidiary of the company), received its first product approval from the US drugs regulator for Lidocaine Hydrochloride Injection, USP, 1 per cent (10 mg/mL) and 2 per cent (20 mg/mL).” The sANDA (abbreviated new drug application) was submitted as Prior Approval Supplement for addition of an alternate drug product manufacturing, labelling, packaging, and testing facility, the filing stated further. By Online Bureau ,

Drug Approval

23 Aug 2024

·pharma.economictimes.indiatimes.com

Govt bans 156 medicines including antibiotics, painkillers, multivitamins: Here is the full list

New Delhi: In a significant move aimed at safeguarding public health, the Indian government has banned 156 fixed-dose combination (FDC) drugs, including a variety of antibiotics, painkillers, multivitamins, and medications for treating fever and hypertension. This decision marks the largest crackdown on FDCs since 2016, when 344 such drugs were prohibited. The Union Ministry of Health and Family Welfare issued a gazette notification on Thursday, officially prohibiting the manufacture, sale, and distribution of the banned FDCs. The ban was based on the recommendations of an expert panel that reviewed a total of 324 FDCs. Impact on Pharmaceutical Industry The banned FDCs include popular combinations such as mefenamic acid and paracetamol injections, commonly used for pain relief and fever, and omeprazole magnesium with dicyclomine HCl, used to treat abdominal pain. The ban is expected to impact major pharmaceutical companies, including Sun Pharmaceuticals, Cipla, Dr. Reddy's Laboratories, Torrent Pharmaceuticals, and Alkem Laboratories. Fixed Dose Combinations Drug Banned List Here is a table listing all 156 banned Fixed Dose Combinations (FDCs) SN Fixed Dose Combination (FDC) 1 Amylase + Protease + Glucoamylase + Pectinase + Alpha Galactosidase + Lactase + Beta-Gluconase + Cellulase + Lipase + Bromelain + Xylanase + Hemicellulase + Malt diastase + Invertase + Papain 2 Antimony Potassium Tartrate + Dried Ferrous Sulphate 3 Benfotiamine + Silymarin + L-Ornithine L-aspartate + Sodium Selenite + Folic acid + Pyridoxine hydrochloride 4 Bismuth Ammonium Citrate + Papain 5 Cyproheptadine HCl + Thiamine HCl + Riboflavine + Pyridoxine HCl + Niacinamide 6 Cyproheptadine Hydrochloride + Tricholine Citrate + Thiamine Hydrochloride + Riboflavine + Pyridoxine Hydrochloride 7 Rabeprazole Sodium (As enteric coated tablet) + Clidinium Bromide + Dicyclomine HCl + Chlordiazepoxide 8 Fungal Diastase + Papain + Nux vomica Tincture + Cardamom Tincture + Casein Hydrolysed + Alcohol 9 Mefenamic Acid + Paracetamol Injection 10 Omeprazole Magnesium + Dicyclomine HCl 11 S-adenosyl methionine + Metadoxine + Ursodeoxycholicacid BP + L-Methylfolate Calcium eq. to L- Methylfolate + Choline bitartratee + Silymarin + L-ornithine Laspartate + Inositol + Taurine 12 Silymarin + Thiamine Mononitrate + Riboflavin + Pyridoxine HCl + Niacinamide + Calcium pantothenate + Vitamin B12 13 Silymarin + Pyridoxine HCl + Cyanocobalamin + Niacinamide + Folic Acid 14 Silymarin + Vitamin B6 + Vitamin B12 + Niacinamide + Folic acid + Tricholine Citrate 15 Sodium Citrate + Citric Acid Monohydrate Flavored with Cardamom Oil, Caraway Oil, Cinnamon Oil, Clove Oil, Ginger Oil + Alcohol 16 Sucralfate + Acelofenac 17 Sucralfate + Domperidone + Dimethicone 18 Sucralfate + Domperidone 19 Tincture Ipecacuanha + Tincture Urgenia + Camphorated Opium Tincture + Aromatic Spirit of Ammonia + Chloroform + Alcohol 20 Ursodeoxycholic Acid + Metformin HCl 21 Weak Ginger tincture + Aromatic Spirit of Ammonia + Peppermint Spirit + Chloroform + Sodium Bicarbonate + Compound Cardamom + Alcohol 22 Sucralfate + Pantoprazole Sodium + Zinc Gluconate + Light Magnesium Carbonate 23 Aloe + Vitamin E Soap 24 Povidone Iodine+ Metronidazole + Aloe 25 Azelaic acid + Tea Tree Oil + Salicylic acid + Allantoin + Zinc oxide + Aloe vera + Jojoba oil + Vitamin E + Soap noodles 26 Azithromycin + Adapalene 27 Calamine + Aloes + Allantoin 28 Calamine + Diphenhydramine Hydrochloride + Aloe + Glycerine + Camphor 29 Chlorphenesin + Zinc oxide + Starch 30 Clindamycin Phosphate + Zinc acetate 31 Gamma Benzene Hexachloride + Benzocaine 32 Glucosamine hydrochloride + Diacerein + Menthol + Camphor + Capsaicin 33 Hydroxyquinone 2.0%w/w + Octyl Methoxycinnamate 5.0% w/w + Oxybenzone 30 % w/w 34 Ketoconazole +Zinc Pyrithione +D-Panthenol +Tea Tree Oil +Aloes 35 Ketoconazole +Aloe vera+ Vitamin A Acetate 36 Ketoconazole +Aloes + ZPTO 37 Kojic Acid +Arbutin +Octinoxate +Vitamin E + Mulberry 38 Lornoxicam +capsaicin +menthol+ camphor 39 Lornoxicam + Thiocolchicoside +Oleum Lini +Menthol + Methyl salicylate 40 Menthol + Aloe vera Topical Spray 41 Menthol +Lignocaine HCl +Aloe vera gel +Clotrimazole +Diphenhydramine 42 Miconazole nitrate + Gentamicin + Fluocinolone Acetonide +Zinc Sulphate 43 Miconazole +Tinidazole 44 Minoxidil +Aminexil+ Alcohol 45 Minoxidil +Azelaic acid + saw palmetto 46 Minoxidil +Aminexil 47 Pine Bark extract+ Kojic acid +Sodium Ascorbyl Phosphate 48 Povidone Iodine +Tinidazole +Zinc sulphate 49 Povidone Iodine + Ornidazole + Dexpanthenol 50 Salicyclic acid +Aloe vera+ Allantoin +D-Panthenol 51 Silver sulphadiazine +Chlorhexidine Gluconate solution +Allantoin + Aloe vera gel +Vitamin E acetate 52 Sodium salicylate + Zinc gluconate + Pyridoxine HCl 53 Tetracycline + Colistin Sulphate 54 Clomiphene +Ubidecarenone 55 Combikit of Clomiphene Citrate + Estradiol Valerate 56 Flavoxate HCl +Ofloxacin 57 Clomiphene Citrate +N-Acetylcysteine 58 Primerose Oil +Cod liver oil 59 Sildenafil Citrate +Papaverine +L-Arginine 60 Tranexamic acid +Mefenamic acid + Vitamin K1 61 Divalproex Sodium +Oxcarbazepine 62 Divalproex Sodium + Levetiracitam 63 Ergotamine tartrate +Caffeine + Paracetamol +Prochlorperazine maleate 64 Piracetam + Ginkgo biloba extracts + Vinpocetin 65 Ginkgo biloba + methylcobalamin 66 Ginkgo biloba + methylcobalamin + Alpha lipoic acid +Pyridoxine HCl 67 Ginseng Extract +Dried extract of Ginkgo Biloba 68 Meclizine HCl+ Paracetamol + Caffeine 69 Nicergoline + Vinpocetine 70 Gamma Linolenic Acid + Methylcobalamin 71 Beclomethasone Dipropionate + Neomycin Sulphate + Clotrimazole + Lignocaine HCl 72 Boric acid+ Phenylephrine HCl + Naphazoline Nitrate + Menthol + Camphor 73 Naphazoline HCl + Chlorpheniramine Maleate + Zinc Sulphate + Hydroxy Propyl Methyl Cellulose 74 Chlorpheniramine Maleate + Naphazoline HCl + Zinc Sulphate + Sodium Chloride + Hydroxy Propyl Methyl Cellulose 75 Chlorpheniramine Maleate + Naphazoline HCl + Hydroxy Propyl Methyl Cellulose 76 Chlorpheniramine Maleate + Sodium Chloride + Boric Acid + Tetrahydrozoline HCl 77 Chlorpheniramine Maleate + Phenylephrine HCl + Antipyrine 78 Ketorolac Tromethamine + Chlorpheniramine Maleate + Phenylephrine HCl + Hydroxy Propyl Methyl Cellulose 79 Ketorolac Tromethamine + Flurometholone 80 Naphazoline HCl + Zinc Sulphate + Boric Acid + Sodium Chloride+ Chlorpheniramine Maleate 81 Naphazoline HCl + Hydroxy Propyl Methyl Cellulose + Boric Acid + Borax + Menthol + Camphor 82 Naphazoline HCl + Hydroxy Propyl Methyl Cellulose + Chlorpheniramine Maleate SN Fixed Dose Combination (FDC) 83 Diphenhydramine Hydrochloride + Phenylephrine Hydrochloride + Menthol + Camphor 84 Diphenhydramine Hydrochloride + Phenylephrine Hydrochloride + Sodium Chloride + Hydroxy Propyl Methyl Cellulose 85 Diphenhydramine Hydrochloride + Phenylephrine Hydrochloride + Sodium Chloride + Methylparaben 86 Methenamine + Sodium Benzoate + Benzyl Alcohol 87 Paracetamol + Phenylephrine Hydrochloride + Chlorpheniramine Maleate 88 Paracetamol + Phenylephrine Hydrochloride + Chlorpheniramine Maleate + Caffeine 89 Propoxyphene + Chlorpheniramine Maleate 90 Propoxyphene + Phenylephrine Hydrochloride + Chlorpheniramine Maleate 91 Propoxyphene + Diphenhydramine Hydrochloride + Phenylephrine Hydrochloride 92 Sodium Benzoate + Sodium Citrate + Citric Acid 93 Vitamin A Palmitate + Vitamin C + Vitamin E + Vitamin B6 + Vitamin B12 94 Vitamin A Palmitate + Vitamin C + Vitamin E + Niacinamide 95 Vitamin B6 + Vitamin B12 + Vitamin C 96 Vitamin B6 + Vitamin B12 + Niacinamide 97 Vitamin B12 + Vitamin B6 + Vitamin C + Folic Acid 98 Vitamin B12 + Vitamin B6 + Niacinamide + Folic Acid 99 Vitamin C + Vitamin E + Vitamin A + Niacinamide 100 Vitamin D + Calcium + Magnesium 101 Vitamin D + Calcium + Magnesium + Zinc 102 Calcium + Vitamin D + Vitamin K 103 Calcium + Vitamin D + Magnesium + Zinc 104 Calcium + Vitamin D + Vitamin K + Magnesium 105 Calcium + Vitamin D + Vitamin K + Magnesium + Zinc 106 Vitamin E + Vitamin A + Vitamin C + Niacinamide 107 Vitamin E + Vitamin A + Vitamin C + Folic Acid 108 Vitamin E + Vitamin A + Vitamin C + Biotin 109 Vitamin E + Vitamin A + Vitamin C + Vitamin B12 110 Vitamin E + Vitamin C + Folic Acid 111 Vitamin E + Vitamin C + Biotin 112 Vitamin E + Vitamin C + Vitamin B12 113 Vitamin E + Vitamin C + Zinc 114 Calcium + Vitamin D + Omega-3 Fatty Acids 115 Calcium + Vitamin D + Omega-3 Fatty Acids + Vitamin K 116 Calcium + Vitamin D + Omega-3 Fatty Acids + Vitamin K + Magnesium 117 Calcium + Vitamin D + Omega-3 Fatty Acids + Vitamin K + Zinc 118 Vitamin A + Vitamin C + Vitamin E + Beta-Carotene 119 Vitamin A + Vitamin C + Vitamin E + Beta-Carotene + Zinc 120 Vitamin C + Vitamin E + Beta-Carotene 121 Vitamin C + Vitamin E + Beta-Carotene + Zinc 122 Vitamin C + Vitamin E + Selenium 123 Vitamin D + Calcium + Vitamin K + Omega-3 Fatty Acids 124 Vitamin D + Calcium + Vitamin K + Omega-3 Fatty Acids + Magnesium 125 Vitamin D + Calcium + Vitamin K + Omega-3 Fatty Acids + Zinc 126 Vitamin D + Calcium + Vitamin K + Omega-3 Fatty Acids + Biotin 127 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Selenium 128 Vitamin E + Vitamin A + Vitamin C + Zinc 129 Vitamin E + Vitamin A + Vitamin C + Selenium 130 Vitamin E + Vitamin A + Vitamin C + Biotin 131 Vitamin E + Vitamin A + Vitamin C + Folic Acid + Niacinamide 132 Vitamin E + Vitamin C + Beta-Carotene + Zinc 133 Vitamin C + Vitamin E + Biotin + Folic Acid 134 Vitamin C + Vitamin E + Beta-Carotene + Folic Acid 135 Vitamin C + Vitamin E + Beta-Carotene + Selenium 136 Vitamin E + Vitamin C + Beta-Carotene + Biotin 137 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Biotin 138 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Selenium 139 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Vitamin B12 140 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Vitamin B6 141 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Folate 142 Calcium + Vitamin D + Magnesium + Vitamin K + Omega-3 Fatty Acids 143 Calcium + Vitamin D + Magnesium + Vitamin K + Biotin 144 Calcium + Vitamin D + Magnesium + Vitamin K + Selenium 145 Calcium + Vitamin D + Magnesium + Vitamin K + Vitamin B12 146 Calcium + Vitamin D + Magnesium + Vitamin K + Folate 147 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Vitamin B6 148 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Vitamin B12 149 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Folic Acid 150 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Biotin 151 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Selenium 152 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids 153 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids + Zinc 154 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids + Biotin 155 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids + Selenium 156 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids + Vitamin B12

Drug Approval

100 Deals associated with Lidocaine Hydrochloride

External Link

KEGG	Wiki	ATC	Drug Bank
D02086	Lidocaine Hydrochloride	D04AB01 S02DA01 C01BB01	-

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Pain	United States	Powder Pharmaceuticals, Inc.	16 Aug 2007
Ventricular Arrhythmia	United States	Hospira, Inc.	19 Dec 1980
Tachycardia, Ventricular	China	Dongbei Pharmaceutical Group Co. Shenyang No 1 Pharm Co. Ltd.	01 Jan 1976
Anesthesia	United States	Fresenius Kabi USA LLC	19 Nov 1948

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Acute Pain	Phase 3	China	Lee's Pharmaceutical Holdings Ltd.	15 Aug 2018
Catheter site discomfort	Phase 3	China	Lee's Pharmaceutical Holdings Ltd.	15 Aug 2018
Uterine Cervical Cancer	Phase 3	China	Lee's Pharmaceutical Holdings Ltd.	15 Aug 2018

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03254394 (CTgov)	Phase 1/2	Colorectal Cancer \| Neuropathy, Painful	26	Placebo+LEUCOVORIN CALCIUM+Oxaliplatin+Fluorouracil (Placebo + FOLFOX)	esipshedsu(iqfnvybbfw) = oxlosmccvr ddeuwblcuq (hxjksxqafp, 18.3) View more	-	09 Mar 2022
				Lidocaine hydrochloride+LEUCOVORIN CALCIUM+Oxaliplatin+Fluorouracil (Lidocaine + FOLFOX)	esipshedsu(iqfnvybbfw) = tftxvhlscz ddeuwblcuq (hxjksxqafp, 14.4) View more
NCT03310970 (CTgov)	Phase 4	-	23	Lidocaine hydrochloride	hpnuatycoc(hmvwlchobi) = xhhyrcaalv qqllwmbuxo (xsmusfazzp, komsoinkbc - qevwvguohc) View more	-	01 Nov 2021
NCT04467424 (Lidoketofol, CTgov)	Phase 2	-	200	propofol+ketamine (Pediatric Anesthesia With Ketofol)	xoylmfsvoq(jbadwtnksa) = tjqaucptva xbjcoqezxx (pyskizncbs, ryffmifxvf - pkdoeagljn) View more	-	04 Feb 2021
				lidocaine+propofol+ketamine (Pediatric Anesthesia With Ketofol Plus Lidocaine)	xoylmfsvoq(jbadwtnksa) = bxsmdvbtob xbjcoqezxx (pyskizncbs, oztkkwovnj - hhffvdpomo) View more
NCT03402321 (Pubmed \| Clin Oral Investig)	Phase 4	Wounds and Injuries	36	Alvogyl	ogtzkdvvjo(acvzwpzwqc) = fwhhvpimrs udwqshpuwm (pprfpuxniq ) View more	-	01 Apr 2020
				Absorbable gelatin sponge	ogtzkdvvjo(acvzwpzwqc) = evkcvmywfn udwqshpuwm (pprfpuxniq ) View more
NCT03096444 (CTgov)	Phase 2	Pruritus	13	Lidocaine hydrochloride+Amitriptyline hydrochloride+Ketamine hydrochloride (Topical KeAmLi Combo)	nbnszdujey(xtwdayeueo) = nsxydaidcp qhbkolasgl (gfggefrpqf, 29.00397851) View more	-	02 Jul 2019
				Ketamine Hydrochloride (Topical Ketamine)	nbnszdujey(xtwdayeueo) = xpxwvehuly qhbkolasgl (gfggefrpqf, 30.11218341) View more
NCT03057704 (CTgov)	Phase 4	Pain	50	Lidocaine injection flushed (Intravenous Lidocaine: Flushed)	ngruiqfabw(kfdhhlrkpi) = tgxktkbzaf jusneenhyo (hourxsregy, 1.0) View more	-	13 Feb 2018
				Lidocaine injection tourniquet (Intravenous Lidocaine: Tourniquet)	ngruiqfabw(kfdhhlrkpi) = szoogfcxrk jusneenhyo (hourxsregy, 0.2) View more
NCT00953199 (CTgov)	Not Applicable	Post-ERCP Pancreatitis	506	Lidocaine Hydrochloride (Lidocaine)	whajidlidn = vzfuvrcvgl uiufpwkynf (gxqhtzwavh, mdrtfyhcig - qjquhktthp) View more	-	03 Oct 2017
				Normal Saline (Normal Saline)	whajidlidn = wiqnzkqgec uiufpwkynf (gxqhtzwavh, ozmtiuzofn - dmfzscrgku) View more
NCT01496846 (ARTIC, CTgov)	Phase 4	Pulpitis \| occlusions	201	SUP Articaine (SUP Articaine)	hoaphrphjo(stcqqpiiyk) = tmrwqcqibm sdvrmthmog (ggropthqwb, qfegsqstmo - hitdeacxuq) View more	-	13 Sep 2017
				IANB Articaine+SUP Lidocaine (SUP Lidocaine)	hoaphrphjo(stcqqpiiyk) = vpxvcjcoyk sdvrmthmog (ggropthqwb, zyvcgyqpdd - smlydaagzw) View more
NCT00721110 (CTgov)	Not Applicable	-	64	Lidocaine (Lidocaine)	fdzbmectri(ztchqveqdi) = xjpxzmciec vnwlcoqolj (mktdhbiiyb, 66) View more	-	26 Jul 2017
				Ketamine (Ketamine)	fdzbmectri(ztchqveqdi) = xsjtkoiwcy vnwlcoqolj (mktdhbiiyb, 77) View more
NCT02447029 (SALSA, CTgov)	Phase 3	Pain \| Induced Abortion	142	vaginal 2% Xylocaine (Active Comparator)	wmwfphjoti(eyqctlpmsb) = akapvwsckr nxynwnwdku (cdprjbaocj, opmwnskrry - ginvebxcti) View more	-	24 Jul 2017
				lidocaine (Standard Lidocaine Paracervical Block)	wmwfphjoti(eyqctlpmsb) = zozscaemmx nxynwnwdku (cdprjbaocj, ajvpeiklao - crczrdjznp) View more

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis