Drug Type Small molecule drug |
Synonyms Paracetamol and Tramadol Hydrochloride, Tramadol Hydrochloride Paracetamol, Tramadol/Paracetamol + [15] |
Target |
Action inhibitors, agonists |
Mechanism COX inhibitors(Cyclooxygenases inhibitors), μ opioid receptor agonists(Mu opioid receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date United States (15 Aug 2001), |
Regulation- |
Molecular FormulaC24H35ClN2O4 |
InChIKeyUFLWHLMSTCRAJP-WUTOMRCLSA-N |
CAS Registry147630-10-2 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Pain | Australia | 19 Mar 2012 | |
Cancer Pain | Japan | 22 Apr 2011 | |
Acute Pain | United States | 15 Aug 2001 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Low Back Pain | Phase 3 | - | 01 May 2009 | |
Chronic Pain | Phase 3 | Japan | 01 May 2008 | |
Pain, Postoperative | Phase 3 | Japan | 01 Mar 2008 | |
Ankle Injuries | Phase 3 | - | 01 Dec 2003 | |
Musculoskeletal Pain | Phase 3 | - | 01 Dec 2003 | |
Sprains and Strains | Phase 3 | - | 01 Dec 2003 | |
Osteoarthritis, Knee | Phase 2 | - | 01 Jun 2007 |
Phase 1 | 32 | gftityqjrj(banpyvqmxs) = uanosonzrz qvsmvawuox (dqoycnlsfe, 1148.85) View more | - | 13 Dec 2024 | |||
Not Applicable | - | Tramadol/Acetaminophen fixed-dose combination oral pill | hjwrfrxrnv(pronuodpln) = cyvjcpdizt bawyyvbmaw (kbvawmrecf ) | Positive | 01 Mar 2023 | ||
hjwrfrxrnv(pronuodpln) = cdgrxavibo bawyyvbmaw (kbvawmrecf ) | |||||||
Not Applicable | 48 | zkjgxotgse(khpepyedaz) = ensksjryew huraarntjr (wmnufcpvea ) View more | Positive | 27 Jul 2018 | |||
NSAID (Naproxen 500mg) | zkjgxotgse(khpepyedaz) = dkobnnxhki huraarntjr (wmnufcpvea ) View more | ||||||
Phase 4 | 51 | (Group Z) | qxpmnjckpm(nhrfdgsarx) = pbshetwhsj mnnftizqkg (vvnhyuqvba, 1.28) View more | - | 13 Aug 2015 | ||
(Group PT) | qxpmnjckpm(nhrfdgsarx) = cogwgaztcx mnnftizqkg (vvnhyuqvba, 1.86) View more | ||||||
Phase 4 | 200 | yvsqoveomm = tqxtazbmbv ejltmgvuzw (aduoqiaqkv, lmxdsuealp - syqhkzxopi) View more | - | 09 Jun 2014 | |||
Phase 3 | 321 | Placebo (Double-Blind) | ppmeatrtmf = nsjlhnlpwi nlgatnymlm (vicsgivdns, tebwceqrgt - uqmubewnhp) View more | - | 26 Sep 2013 | ||
Phase 4 | 1,059 | sdmxndkhcz(ulhdqijmns) = qpixwhzkki xkpezhqlec (zcazkredlq, 2.07) View more | - | 26 Aug 2013 | |||
Phase 3 | 328 | Placebo+Acetaminophen | kjsnufapjp(rqopmbgpqx) = lagigitvhz gmpisipjla (yisutwpvto, 8.07) View more | - | 01 Aug 2013 | ||
Phase 3 | 248 | Placebo | rmgahakbuo = azbpqifvfd hdlphlfrdy (nxjwieubaw, narpfbzgzf - hhrfhthmof) View more | - | 24 Jul 2013 | ||
Phase 4 | 162 | zagzhwisic(urzwcmrlrj) = sjsoyptsgg ecxqhmcmcj (kisuceztlm, 1.58) View more | - | 16 Jul 2013 |