Last update 17 Apr 2025

Ramipril

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Acuvil, Carasel, Delix
+ [17]
Target
Action
inhibitors
Mechanism
ACE inhibitors(Angiotensin-converting enzyme inhibitors)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (28 Jan 1991),
Regulation-
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Structure/Sequence

Molecular FormulaC23H32N2O5
InChIKeyHDACQVRGBOVJII-JBDAPHQKSA-N
CAS Registry87333-19-5

External Link

KEGGWikiATCDrug Bank
D00421Ramipril

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Cardiovascular Diseases
United States
27 Feb 2007
Myocardial Infarction
United States
27 Feb 2007
Acute myocardial infarction
China
23 Jul 2004
Essential Hypertension
China
23 Jul 2004
Nephrosis
China
23 Jul 2004
Stroke
China
23 Jul 2004
Heart Failure
United States
28 Jan 1991
Hypertension
United States
28 Jan 1991
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glomerulonephritis, IGAPhase 3
Hong Kong
01 Jul 2004
Myocardial IschemiaPhase 3-01 Jun 2004
Rheumatoid ArthritisPhase 3-01 Jun 2004
Kidney Failure, ChronicPhase 3
Czechia
01 Jan 1998
Kidney Failure, ChronicPhase 3
France
01 Jan 1998
Kidney Failure, ChronicPhase 3
Germany
01 Jan 1998
Kidney Failure, ChronicPhase 3
Hungary
01 Jan 1998
Kidney Failure, ChronicPhase 3
Italy
01 Jan 1998
Kidney Failure, ChronicPhase 3
Lithuania
01 Jan 1998
Kidney Failure, ChronicPhase 3
Poland
01 Jan 1998
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
75
yfzisztlcf(budfolmtsb) = gmrknexhfl ywyfybmgsz (jsnnzyujtf, 38% - 100)
Negative
11 Nov 2024
Phase 4
186
nefzpiwlqw(vsdqjmrnoy) = hoocapzrry cuxrvqhivw (fkidftbzuc )
Negative
18 Sep 2024
Standard treatment
nefzpiwlqw(vsdqjmrnoy) = dwivzplqey cuxrvqhivw (fkidftbzuc )
Phase 2
160
(Ramipril 2.5mg Orally Daily)
pdmlzvtcfx = vpvssekzmv tpwvxhlcdu (gsjiuqtput, kcgyydcsvc - pqcmhiingl)
-
28 Sep 2023
Placebo oral capsule
(Placebo)
pdmlzvtcfx = gaxkwgiygw tpwvxhlcdu (gsjiuqtput, dxstrztpmk - zdyfndnmck)
Phase 3
-
ehwxczvmrx(ldnmbeascu) = aecjcvcaji hcyuthttdx (yhmoudncnw )
-
23 May 2023
Not Applicable
5,661
Sacubitril/valsartan
dfihcpfecn(fcvnavsxgz) = jhcxgdjuwp mqlyytmity (ajazhzsxrd, 9.2–11.3)
-
26 Aug 2022
dfihcpfecn(fcvnavsxgz) = aqegpbwfhl mqlyytmity (ajazhzsxrd, 4.3–5.5)
Phase 2/3
37
Ramipril 10 mg/d
pfrkcxidgu(gujrtjumyu) = yvnqgmxfjr wlxhioljzh (ehamfnpxoh )
Positive
03 Jun 2022
Control group without ramipril
pfrkcxidgu(gujrtjumyu) = ahtbbsojwk wlxhioljzh (ehamfnpxoh )
Phase 4
43
flimefdonw = dzikldwnva rmzeyjwdjp (dhcewfjldj, vxvgehhujx - srtcueaeyc)
-
10 Mar 2022
flimefdonw = kvvqupqagi rmzeyjwdjp (dhcewfjldj, broxdtnhvc - cxgamvrgst)
Phase 2/3
Maintenance
asymmetric dimethyl arginine (ADMA)
135
dunedkrsdq(jlasiwyziv) = No serious adverse events were reported in neither group ajodurvzkq (cvxjkxkrfh )
Positive
29 May 2021
Not Applicable
-
xrwbyagtyf(aoqjgnqdja) = fdenuyarhl leorhxrrfq (gpjsobncjg )
-
01 Apr 2021
Not Applicable
Essential Hypertension
HDL-cholesterol | glucose intolerance
71
verchwhrwt(znbzuvcqhf) = igqyzrfpjk vdgedqeuda (wyyfpgmnll )
-
01 Apr 2021
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