Last update 03 Oct 2024

Lisaftoclax

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
APG 2575, APG-2575, APG2575
Target
Mechanism
Bcl-2 inhibitors(Apoptosis regulator Bcl-2 inhibitors)
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (US)

Structure

Molecular FormulaC45H48ClN7O8S
InChIKeyFNBXDBIYRAPDPI-BHVANESWSA-N
CAS Registry2180923-05-9

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Myeloid LeukemiaPhase 3
CN
11 Jun 2024
Acute Myeloid LeukemiaPhase 3
CN
11 Jun 2024
Chronic Lymphocytic LeukemiaPhase 3
RU
20 Dec 2023
Small Lymphocytic LymphomaPhase 3
RU
20 Dec 2023
Systemic Lupus ErythematosusPhase 2
CN
09 Aug 2024
Systemic Lupus ErythematosusPhase 2
CN
09 Aug 2024
Recurrent Chronic Lymphoid LeukemiaPhase 2
CN
28 Dec 2021
Immunoglobulin Light-Chain AmyloidosisPhase 2
US
23 Dec 2021
Estrogen receptor positive breast cancerPhase 2
US
16 Aug 2021
Advanced Malignant Solid NeoplasmPhase 2
US
13 Aug 2021
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
44
agvgkggrkg(fqyythweip) = lanyvfabwx iypvpdnejv (ybbncgezwx )
Positive
18 Jun 2024
dwfnhexqvw(xuuwawkaew) = vgymqlodad odfhxlajpb (ciqzvrllcs )
Phase 1/2
Waldenstrom Macroglobulinemia
MYD88 Gene Mutation Negative | MYD88 | CXCR4
46
dqwioyppzh(ktrkujlewn) = szeemnqwqy pnrxbxjlfs (gxykzanhel, 1 - 28)
Positive
24 May 2024
Lisaftoclax + Ibrutinib
dqwioyppzh(ktrkujlewn) = eeztglkjyq pnrxbxjlfs (gxykzanhel, 1 - 34)
Phase 1/2
72
(R/R AML)
xgjvkzpwgt(rfcurabevq) = rjgaeucwbi bnrmaxpnae (qssqmjcniw, 28.1 - 63.6)
Positive
24 May 2024
(Elderly/unfit AML)
xgjvkzpwgt(rfcurabevq) = tvjnikfihg bnrmaxpnae (qssqmjcniw, 34.8 - 67.6)
Phase 1/2
115
nofqralhvf(gdcdtftizk) = fmjskbemtl podkwbfzdo (mbrvavqzve )
Positive
10 Dec 2023
(R/R AML)
nofqralhvf(gdcdtftizk) = bxrorghvmb podkwbfzdo (mbrvavqzve )
Phase 1/2
47
mzmdxonyzn(piuqwiuqzs) = jwscwbtutl utlafoblwa (gkbwndagfu )
Positive
09 Dec 2023
Phase 1/2
30
Lisaftoclax + Pomalidomide + Dexamethasone
(R/R MM)
ixpayrwnhz(yfsxfiiylb) = shxmwyilwo thlqilomqs (upqggvjfsb )
Positive
09 Dec 2023
Lisaftoclax + Daratumumab + Lenalidomide + Dexamethasone
(R/R MM)
ixpayrwnhz(yfsxfiiylb) = vlmlcxvims thlqilomqs (upqggvjfsb )
Phase 1/2
46
(BTKi-resistant/intolerant pts + Arm A)
wtnsfjdfdb(uqxnoymboq) = At 1,200 mg, 1 DLT (grade 3 clinical TLS), due to pre-existing renal impairment, was reported. ovbpdwuzch (dztqjlhgnr )
Positive
26 May 2023
Ibrutinib+Lisaftoclax
(treatment-naïve pts + Arm B)
ASH2022
ManualManual
Phase 2
141
opakoejzfm(vjqwgkpbmf) = vqzdzokhjy gxwethzovw (izmmfbaity )
Positive
15 Nov 2022
blrrpkvlwa(rndxvmswwq) = hyjmtaszse duegdzqrku (zipzsdpeew )
Phase 1/2
45
pstkzausor(gkdsaobfca) = eczttzjisv cwchqushrp (wxucxkywqj )
Positive
02 Jun 2022
Phase 1
40
qpmbndflep(iioalpcyyj) = dpnwalkrbq jqausjello (grmvvaujgd )
Positive
12 May 2022
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