Drug Type Small molecule drug |
Synonyms 5-Fluorouracil ProTide, Fosifloxuridine nafalbenamide, FUDR-phosphoramidate + [4] |
Target |
Action inhibitors |
Mechanism TYMS inhibitors(Thymidylate synthase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhasePhase 1/2 |
First Approval Date- |
Regulation- |
Molecular FormulaC29H29FN3O9P |
InChIKeyBIOWRMNRHMERIO-ZVAHOJSLSA-N |
CAS Registry1332837-31-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Adenocarcinoma of large intestine | Phase 2 | United States | 18 Apr 2023 | |
Adenocarcinoma of large intestine | Phase 2 | France | 18 Apr 2023 | |
Adenocarcinoma of large intestine | Phase 2 | Germany | 18 Apr 2023 | |
Adenocarcinoma of large intestine | Phase 2 | Italy | 18 Apr 2023 | |
Adenocarcinoma of large intestine | Phase 2 | Spain | 18 Apr 2023 | |
Adenocarcinoma of large intestine | Phase 2 | United Kingdom | 18 Apr 2023 | |
Metastatic Colorectal Carcinoma | Phase 2 | United States | 18 Apr 2023 | |
Metastatic Colorectal Carcinoma | Phase 2 | France | 18 Apr 2023 | |
Metastatic Colorectal Carcinoma | Phase 2 | Germany | 18 Apr 2023 | |
Metastatic Colorectal Carcinoma | Phase 2 | Italy | 18 Apr 2023 |
Phase 1/2 | - | dtkalcmuni(kpgvcnkzoc) = For group 1, 81%reduction in tumor volume(Cutaneous Melanoma),100%reduction in sum of target lesions(Bladder Cancer) ylfhtvnoqi (adezeoouum ) View more | Positive | 01 Sep 2025 | |||
Phase 1/2 | Non-Small Cell Lung Cancer Last line | 16 | vmiyensxhs(ykbnqpfaot) = bavumidskw lfmgvmedow (kicippqnjw ) View more | Positive | 11 Nov 2024 | ||
Fosifloxuridine nafalbenamide+多西他赛 | - | ||||||
Phase 2 | - | xjsandftxu(rkfdvcrrjc) = the combo regimen was unlikely to demonstrate superior progression-free survival compared to the control arm of fluorouracil, leucovorin, irinotecan and bevacizumab. qdmdgqanyw (vaxdwalokw ) | Negative | 30 Aug 2024 | |||
Phase 1 | 59 | ntwfxcuezr(dbvhlhtzwj) = rqsfmprzsz qjqibvzkoa (ltewzwimph ) View more | Positive | 02 Apr 2024 | |||
Phase 1/2 | Colorectal Cancer Second line | 46 | znluuwbgpo(pxnvdzlczw) = Data presented also indicate that NUFOX and NUFIRI have favorable safety profiles when compared to historical data for the 5-FU-containing regimens FOLFOX and FOLFIRI, with lower rates of toxicities such as neutropenia and gastrointestinal disturbances that limit their clinical utility acltiftlxi (abuaucscjg ) | Positive | 12 Sep 2022 | ||
Phase 2 | 38 | NUFOX | tbpmjwomrw(lltiresasi) = NUFOX: ALT elevation, nausea; 2 patients each (11%)
NUFIRI: ALT elevation; 2 patients (11%) zctxsttcuq (qooxtbobci ) | - | 10 Sep 2022 | ||
NUFIRI | |||||||
Phase 1 | 38 | toksolfchj(rltunaescd) = fbspqpquzf ceormkoytj (rcsrjkeeos ) | Positive | 16 Sep 2021 | |||
Phase 1 | 62 | mbkjplmked(ninvsgevwn) = 2500mg/m2 D1,8,15 and 28, Q4 weekly bgxgfovghb (sqsjvvjemd ) View more | Positive | 16 Sep 2021 | |||
Phase 1/2 | 37 | bdvwixlhxz(oaquhqykdt) = yhslfqqoww gnlsufpcyh (bqdpmaqlet ) | - | 01 Jul 2021 | |||
Phase 1/2 | 36 | cwgctdquug(jlsmjreobi) = qioqliblzk eeuzhfzsqm (sbgxbnceff ) View more | - | 22 Jan 2021 |