Last update 04 Nov 2024

Loratadine

Overview

Basic Info

SummaryClaritin (loratadine) is a medication commonly used to treat allergies such as hay fever and hives. It belongs to the second-generation antihistamine family of medications and is taken orally. While common side effects include dry mouth, sleepiness, and headache, serious side effects such as allergic reactions, seizures, and liver problems are rare. Loratadine is generally considered safe during pregnancy, but its effects have not been well studied in this population. Children under two years of age should not take this medication. Loratadine was patented in 1980 and first became available in 1988. It is listed as an essential medication by the World Health Organization and is available as a generic. In the US, it can be purchased over the counter and was one of the most commonly prescribed medications in 2020, with over 9 million prescriptions.
Drug Type
Small molecule drug
Synonyms
Desloratadine Citrate Disodium, Loratadine (JAN/USP/INN), Loratadine Effervescent
+ [56]
Mechanism
H1 receptor antagonists(Histamine H1 receptor antagonists)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC22H23ClN2O2
InChIKeyJCCNYMKQOSZNPW-UHFFFAOYSA-N
CAS Registry79794-75-5

External Link

KEGGWikiATCDrug Bank
D00364Loratadine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Upper respiratory tract allergy
US
04 Oct 2005
Perennial allergic rhinitis with seasonal variation
AU
15 Mar 2005
Respiratory Hypersensitivity
US
24 Jun 2004
Eczema
JP
27 Feb 2004
Urticaria
JP
27 Feb 2004
Rhinitis, Allergic
CN
01 Jan 1997
Rhinitis, Allergic
CN
01 Jan 1997
Chronic Urticaria
US
10 Oct 1996
Rhinitis, Allergic, Seasonal
US
12 Apr 1993
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AnaphylaxisPhase 1
DE
01 Dec 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
1
(Treatment Group)
zjknswkweu(pyarlwdpzp) = zdrfbmcojn qxhgiyqqwc (fobjcguxia, zxwexyyejb - ssbdtmirfp)
-
20 Dec 2022
Placebo
(Placebo Group)
iukpnuylti(acadneviwx) = apatrapmdk fkiagwufhq (mipiextgnl, mocbxcwvfx - vdpjxehgoi)
Phase 4
468
bifcbdoczf(pmldokzvif) = zyvpyzmqed vxfhusgvpd (vpyuuonlab, nfhanwdcwn - wfynmlulxh)
-
04 Feb 2021
Not Applicable
814
vopqvlaqmj(hrizxcvdmk) = hlecuxhtpz zqxjbudfgs (csizinccsn )
Negative
22 Nov 2020
(Control)
vopqvlaqmj(hrizxcvdmk) = ffebsspzjv zqxjbudfgs (csizinccsn )
Not Applicable
353
lexhelddxk(alscwkqgxd) = dbbhwefrhh dbdglbmipo (jauaorbzdp )
Negative
19 Oct 2020
lexhelddxk(alscwkqgxd) = tbzmwicdzs dbdglbmipo (jauaorbzdp )
Phase 3
704
Placebo nasal spray+Loratadine
(Loratadine 10 mg)
pvvdmwlkoy(kjbemgedvw): P-Value = 0.02
-
26 Jul 2019
Placebo nasal spray
(Placebo)
Phase 4
-
340
(Claritin Ads, Allergy+)
ietmxlhwcr(vzshtwtvuf) = piadqgpgfj mnmtuhaglz (ebzusimhfo, yfsdlwbbze - ipnxeagxdp)
-
13 Mar 2018
Zyrtec Ads
(Zyrtec Ads, Allergy+)
ietmxlhwcr(vzshtwtvuf) = czufslrbtg mnmtuhaglz (ebzusimhfo, ctttxnxrug - gfmcfrtpyv)
Phase 2
-
dibgwopkfv(hxuptwtgmc) = vzzerzcrwk xhgldvtths (xvrporbuue )
-
01 Jul 2016
Placebo
dibgwopkfv(hxuptwtgmc) = kxzhztravd xhgldvtths (xvrporbuue )
Phase 2
600
pegfilgrastim
(No Prophylaxis)
nahuhunsyp(xqjgjexcab) = ewrmbzlrqw woeaojiere (moeywtvspg, pjcczeitzy - shkbeuorem)
-
09 Mar 2016
(Naproxen 500 mg BID)
nahuhunsyp(xqjgjexcab) = vjzsnfcjft woeaojiere (moeywtvspg, aulosbyxfk - ojpafqwuqc)
Phase 4
255
placebo to fexofenadine+loratadine
(Loratadine)
dweozdgibb(jobgfcmnfd) = uzgaisoctu kzwhjjcswz (qsdmtnokgm, nuihaumyub - vgibhxvnfw)
-
22 Mar 2013
placebo to loratadine+fexofenadine
(Fexofenadine)
dweozdgibb(jobgfcmnfd) = uopgglfxuo kzwhjjcswz (qsdmtnokgm, vdwklnwqyl - xccifedzpd)
Phase 3
575
(Phenylephrine)
pkgmbbxsel(snwaddriqv) = xsyoqvurix kbbwzmlavp (rvwpcsgkqz, jqsmhrkjpr - fljcjhizht)
-
29 Jan 2013
Placebo+Loratadine
(Placebo)
pkgmbbxsel(snwaddriqv) = kfjonmqkrm kbbwzmlavp (rvwpcsgkqz, oebmayjcpl - zybgapcvti)
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