SummaryClaritin (loratadine) is a medication commonly used to treat allergies such as hay fever and hives. It belongs to the second-generation antihistamine family of medications and is taken orally. While common side effects include dry mouth, sleepiness, and headache, serious side effects such as allergic reactions, seizures, and liver problems are rare. Loratadine is generally considered safe during pregnancy, but its effects have not been well studied in this population. Children under two years of age should not take this medication. Loratadine was patented in 1980 and first became available in 1988. It is listed as an essential medication by the World Health Organization and is available as a generic. In the US, it can be purchased over the counter and was one of the most commonly prescribed medications in 2020, with over 9 million prescriptions. |
Drug Type Small molecule drug |
Synonyms Desloratadine Citrate Disodium, Loratadine (JAN/USP/INN), Loratadine Effervescent + [56] |
Target |
Mechanism H1 receptor antagonists(Histamine H1 receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (12 Apr 1993), |
Regulation- |
Molecular FormulaC22H23ClN2O2 |
InChIKeyJCCNYMKQOSZNPW-UHFFFAOYSA-N |
CAS Registry79794-75-5 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00364 | Loratadine |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Upper respiratory tract allergy | US | 04 Oct 2005 | |
Perennial allergic rhinitis with seasonal variation | AU | 15 Mar 2005 | |
Respiratory Hypersensitivity | US | 24 Jun 2004 | |
Eczema | JP | 27 Feb 2004 | |
Urticaria | JP | 27 Feb 2004 | |
Rhinitis, Allergic | CN | 01 Jan 1997 | |
Rhinitis, Allergic | CN | 01 Jan 1997 | |
Chronic Urticaria | US | 10 Oct 1996 | |
Rhinitis, Allergic, Seasonal | US | 12 Apr 1993 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Anaphylaxis | Phase 1 | DE | 01 Dec 2015 |
Phase 2 | 1 | (Treatment Group) | zjknswkweu(pyarlwdpzp) = zdrfbmcojn qxhgiyqqwc (fobjcguxia, zxwexyyejb - ssbdtmirfp) View more | - | 20 Dec 2022 | ||
Placebo (Placebo Group) | iukpnuylti(acadneviwx) = apatrapmdk fkiagwufhq (mipiextgnl, mocbxcwvfx - vdpjxehgoi) View more | ||||||
Phase 4 | 468 | bifcbdoczf(pmldokzvif) = zyvpyzmqed vxfhusgvpd (vpyuuonlab, nfhanwdcwn - wfynmlulxh) View more | - | 04 Feb 2021 | |||
Not Applicable | 814 | vopqvlaqmj(hrizxcvdmk) = hlecuxhtpz zqxjbudfgs (csizinccsn ) | Negative | 22 Nov 2020 | |||
(Control) | vopqvlaqmj(hrizxcvdmk) = ffebsspzjv zqxjbudfgs (csizinccsn ) | ||||||
Not Applicable | 353 | lexhelddxk(alscwkqgxd) = dbbhwefrhh dbdglbmipo (jauaorbzdp ) View more | Negative | 19 Oct 2020 | |||
lexhelddxk(alscwkqgxd) = tbzmwicdzs dbdglbmipo (jauaorbzdp ) View more | |||||||
Phase 3 | 704 | Placebo nasal spray+Loratadine (Loratadine 10 mg) | pvvdmwlkoy(kjbemgedvw): P-Value = 0.02 View more | - | 26 Jul 2019 | ||
Placebo nasal spray (Placebo) | |||||||
Phase 4 | - | 340 | (Claritin Ads, Allergy+) | ietmxlhwcr(vzshtwtvuf) = piadqgpgfj mnmtuhaglz (ebzusimhfo, yfsdlwbbze - ipnxeagxdp) View more | - | 13 Mar 2018 | |
Zyrtec Ads (Zyrtec Ads, Allergy+) | ietmxlhwcr(vzshtwtvuf) = czufslrbtg mnmtuhaglz (ebzusimhfo, ctttxnxrug - gfmcfrtpyv) View more | ||||||
Phase 2 | - | dibgwopkfv(hxuptwtgmc) = vzzerzcrwk xhgldvtths (xvrporbuue ) View more | - | 01 Jul 2016 | |||
Placebo | dibgwopkfv(hxuptwtgmc) = kxzhztravd xhgldvtths (xvrporbuue ) | ||||||
Phase 2 | 600 | pegfilgrastim (No Prophylaxis) | nahuhunsyp(xqjgjexcab) = ewrmbzlrqw woeaojiere (moeywtvspg, pjcczeitzy - shkbeuorem) View more | - | 09 Mar 2016 | ||
(Naproxen 500 mg BID) | nahuhunsyp(xqjgjexcab) = vjzsnfcjft woeaojiere (moeywtvspg, aulosbyxfk - ojpafqwuqc) View more | ||||||
Phase 4 | 255 | placebo to fexofenadine+loratadine (Loratadine) | dweozdgibb(jobgfcmnfd) = uzgaisoctu kzwhjjcswz (qsdmtnokgm, nuihaumyub - vgibhxvnfw) View more | - | 22 Mar 2013 | ||
placebo to loratadine+fexofenadine (Fexofenadine) | dweozdgibb(jobgfcmnfd) = uopgglfxuo kzwhjjcswz (qsdmtnokgm, vdwklnwqyl - xccifedzpd) View more | ||||||
Phase 3 | 575 | (Phenylephrine) | pkgmbbxsel(snwaddriqv) = xsyoqvurix kbbwzmlavp (rvwpcsgkqz, jqsmhrkjpr - fljcjhizht) View more | - | 29 Jan 2013 | ||
Placebo+Loratadine (Placebo) | pkgmbbxsel(snwaddriqv) = kfjonmqkrm kbbwzmlavp (rvwpcsgkqz, oebmayjcpl - zybgapcvti) View more |