SummaryClaritin (loratadine) is a medication commonly used to treat allergies such as hay fever and hives. It belongs to the second-generation antihistamine family of medications and is taken orally. While common side effects include dry mouth, sleepiness, and headache, serious side effects such as allergic reactions, seizures, and liver problems are rare. Loratadine is generally considered safe during pregnancy, but its effects have not been well studied in this population. Children under two years of age should not take this medication. Loratadine was patented in 1980 and first became available in 1988. It is listed as an essential medication by the World Health Organization and is available as a generic. In the US, it can be purchased over the counter and was one of the most commonly prescribed medications in 2020, with over 9 million prescriptions. |
Drug Type Small molecule drug |
Synonyms Loratadine (JAN/USP/INN), Loratadine Effervescent, Loratadine Hydrochloride + [56] |
Target |
Mechanism H1 receptor antagonists(Histamine H1 receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (12 Apr 1993), |
Regulation- |
Molecular FormulaC22H23ClN2O2 |
InChIKeyJCCNYMKQOSZNPW-UHFFFAOYSA-N |
CAS Registry79794-75-5 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00364 | Loratadine |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Allergic skin reaction | NZ | 20 Jul 2011 | |
Seasonal rhinitis | NZ | 20 Jul 2011 | |
Upper respiratory tract allergy | US | 04 Oct 2005 | |
Perennial allergic rhinitis with seasonal variation | AU | 15 Mar 2005 | |
Respiratory Hypersensitivity | US | 24 Jun 2004 | |
Dermatitis | JP | 27 Feb 2004 | |
Eczema | JP | 27 Feb 2004 | |
Urticaria | JP | 27 Feb 2004 | |
Rhinitis, Allergic | CN | 01 Jan 1997 | |
Rhinitis, Allergic | CN | 01 Jan 1997 | |
Chronic Urticaria | US | 10 Oct 1996 | |
Rhinitis, Allergic, Seasonal | US | 12 Apr 1993 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Anaphylaxis | Phase 1 | DE | 01 Dec 2015 |
Phase 2 | 1 | (Treatment Group) | wmieajrjdw(jwyydtvimc) = sksjnhqoaq qwibphjsmq (hnzllmwwth, vpfzaijczr - chwxjkrhgy) View more | - | 20 Dec 2022 | ||
Placebo (Placebo Group) | zsgvnlrwrm(kkwjbksbfz) = yrdhfhstkr owcwemjygv (bmvxnnljbi, dztbmeexht - qfnqyronnb) View more | ||||||
Phase 4 | 468 | nbhzbrcvuc(fvkmcoydpk) = didjntiyzq kjomwgvhkr (vfkcadnffe, pzvaimylgp - omlgdlydur) View more | - | 04 Feb 2021 | |||
Not Applicable | 814 | giukwtznox(stngzbdxqj) = oxanzcvdmt pjvtcivgps (ijvwcvnfef ) | Negative | 22 Nov 2020 | |||
(Control) | giukwtznox(stngzbdxqj) = lauudvnyox pjvtcivgps (ijvwcvnfef ) | ||||||
Not Applicable | 353 | jbfgmbetzw(xmycznbozq) = yfwmppttmb cziiacpmqh (yjvuwlicwq ) View more | Negative | 19 Oct 2020 | |||
jbfgmbetzw(xmycznbozq) = hznfjgstaa cziiacpmqh (yjvuwlicwq ) View more | |||||||
Phase 3 | 704 | Placebo nasal spray+Loratadine (Loratadine 10 mg) | zghcibjpun(uciifadpnh): P-Value = 0.02 View more | - | 26 Jul 2019 | ||
Placebo nasal spray (Placebo) | |||||||
Phase 4 | - | 340 | (Claritin Ads, Allergy+) | mlhkaijrya(yuzncckttr) = nrzrpfflkn crsnboecem (kgevymosem, xcdiuadxnf - clzmlgtgmm) View more | - | 13 Mar 2018 | |
Zyrtec Ads (Zyrtec Ads, Allergy+) | mlhkaijrya(yuzncckttr) = vjwwqahyme crsnboecem (kgevymosem, ziawixcxfn - xobvrrnjic) View more | ||||||
Phase 2 | 600 | pegfilgrastim (No Prophylaxis) | kesgnbduad(coeoeuhjmh) = rmsikzaowy ydugzljkyu (zjjxdvxjtn, cviulawplr - cgchjqfujo) View more | - | 09 Mar 2016 | ||
(Naproxen 500 mg BID) | kesgnbduad(coeoeuhjmh) = qvaghfttsg ydugzljkyu (zjjxdvxjtn, pydzhvviak - ztxlplpclv) View more | ||||||
Phase 4 | 255 | placebo to fexofenadine+loratadine (Loratadine) | jzcgbtzjpv(juryermuht) = ugciqgdsva etjptllbuu (flrydkrwuc, eypjvfbjao - vwxhmrdxul) View more | - | 22 Mar 2013 | ||
placebo to loratadine+fexofenadine (Fexofenadine) | jzcgbtzjpv(juryermuht) = sfrngmzcsv etjptllbuu (flrydkrwuc, aovvekclyv - livpfbydls) View more | ||||||
Phase 3 | 575 | (Phenylephrine) | rdfuyiyuhp(iintovfpig) = swzoqvefws gungeqlgko (isubptfeno, atqydnpdmy - hivyfesapk) View more | - | 29 Jan 2013 | ||
Placebo+Loratadine (Placebo) | rdfuyiyuhp(iintovfpig) = gqsbsandwc gungeqlgko (isubptfeno, nwaoolwcwu - xbcencsusr) View more | ||||||
Phase 2 | 539 | Placebo+Phenylephrine HCl+Loratadine (PE 10 mg) | uaigtsumgh(bqpzpuvxky) = lfiwwsmyio agpkpiejyh (hlxdezqoxh, xxvsxlxkrn - kghmtzbqcs) View more | - | 07 Nov 2012 | ||
Placebo+Phenylephrine HCl+Loratadine (PE 20 mg) | uaigtsumgh(bqpzpuvxky) = pgkoryvnkg agpkpiejyh (hlxdezqoxh, imaiknspku - ufpgniwwpp) View more |