SummaryClaritin (loratadine) is a medication commonly used to treat allergies such as hay fever and hives. It belongs to the second-generation antihistamine family of medications and is taken orally. While common side effects include dry mouth, sleepiness, and headache, serious side effects such as allergic reactions, seizures, and liver problems are rare. Loratadine is generally considered safe during pregnancy, but its effects have not been well studied in this population. Children under two years of age should not take this medication. Loratadine was patented in 1980 and first became available in 1988. It is listed as an essential medication by the World Health Organization and is available as a generic. In the US, it can be purchased over the counter and was one of the most commonly prescribed medications in 2020, with over 9 million prescriptions. |
Drug Type Small molecule drug |
Synonyms Desloratadine Citrate Disodium, Loratadine (JAN/USP/INN), Loratadine Effervescent + [56] |
Target |
Mechanism H1 receptor antagonists(Histamine H1 receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (12 Apr 1993), |
Regulation- |
Molecular FormulaC22H23ClN2O2 |
InChIKeyJCCNYMKQOSZNPW-UHFFFAOYSA-N |
CAS Registry79794-75-5 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00364 | Loratadine |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Upper respiratory tract allergy | US | 04 Oct 2005 | |
Perennial allergic rhinitis with seasonal variation | AU | 15 Mar 2005 | |
Eczema | JP | 27 Feb 2004 | |
Urticaria | JP | 27 Feb 2004 | |
Chronic Urticaria | CN | 01 Jan 1997 | |
Chronic Urticaria | CN | 01 Jan 1997 | |
Rhinitis, Allergic | CN | 01 Jan 1997 | |
Rhinitis, Allergic | CN | 01 Jan 1997 | |
Rhinitis, Allergic, Seasonal | US | 12 Apr 1993 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Anaphylaxis | Discovery | DE | 01 Dec 2015 |
Phase 2 | 1 | (Treatment Group) | mxxauulbht(rmuwrlntya) = creqeiqqnd llycbnwmyb (nlnpodoixi, wgxtvcrjhx - uenbtbvapc) View more | - | 20 Dec 2022 | ||
Placebo (Placebo Group) | cprpkcoiel(jvnsmmvknq) = jqdjrrgbck smeeocnfqd (ivrtgdbnhb, ryjmylrnsw - iokavgqvwm) View more | ||||||
Phase 4 | 468 | ovdgfvtrzx(ypmwvaguik) = phshxhawvk iocajuploi (ciweqvmxsl, vbqltbifov - ecnooqkvqy) View more | - | 04 Feb 2021 | |||
Not Applicable | 814 | (smvqdbrtgc) = jcpivybwms svnciexldq (qjicrqehcu ) | Negative | 22 Nov 2020 | |||
(Control) | (smvqdbrtgc) = gcybhhfnio svnciexldq (qjicrqehcu ) | ||||||
Not Applicable | 353 | tdbavlzupg(kmgesciadl) = roxgmhhuwm wxwpquwjgj (idktqrkpfo ) View more | Negative | 19 Oct 2020 | |||
tdbavlzupg(kmgesciadl) = voewapmnfq wxwpquwjgj (idktqrkpfo ) View more | |||||||
Phase 3 | 704 | Placebo nasal spray+Loratadine (Loratadine 10 mg) | (psxsofdxxb): P-Value = 0.02 View more | - | 26 Jul 2019 | ||
Placebo nasal spray (Placebo) | |||||||
Phase 3 | 1,025 | Mometasone furoate monohydrate+Self-injectable epinephrine+Olopatadine+Albuterol+Loratadine+Short ragweed pollen allergen extract (Short Ragweed Pollen Allergen Extract) | osazvpxoex(uebsmdyykv) = chpfdfpxgc afululbjjf (pwymvwmakq, dhluejmmox - mzxyzfmmjo) View more | - | 09 Jul 2019 | ||
(Placebo) | osazvpxoex(uebsmdyykv) = rlkxqhjjys afululbjjf (pwymvwmakq, pklviokxtc - fullvmauwn) View more | ||||||
Phase 4 | - | 340 | (Claritin Ads, Allergy+) | wsrasrqnxc(ivyhsonrnw) = lmzjrdahiw szzadktbfp (nuroluwtni, levqvnvznr - hcawxpidnr) View more | - | 13 Mar 2018 | |
Zyrtec Ads (Zyrtec Ads, Allergy+) | wsrasrqnxc(ivyhsonrnw) = hrqtmrndcp szzadktbfp (nuroluwtni, lzijzrdtcy - grsjauudfj) View more | ||||||
Phase 2 | - | egtypawzlt(aviyhashiv) = yzumtqhgzj inmohlhzwh (avyeiwymzl ) View more | - | 01 Jul 2016 | |||
Placebo | egtypawzlt(aviyhashiv) = lvdumhcijd inmohlhzwh (avyeiwymzl ) | ||||||
Phase 2 | 600 | pegfilgrastim (No Prophylaxis) | hklqfzddwx(ewdgxnbawj) = ihfsmweghl qixqaydkcq (oegqeexanu, oaygwsckva - nlqutspefw) View more | - | 09 Mar 2016 | ||
(Naproxen 500 mg BID) | hklqfzddwx(ewdgxnbawj) = zqkdnhmtdw qixqaydkcq (oegqeexanu, cvrnrjtmqv - ilqieczfzw) View more | ||||||
Phase 3 | 84 | Cold Compress+Deoxycholic Acid Injection (Paradigm 1 / Deoxycholic Acid Injection) | jkhtldadhb(ciljacmqif) = ewmbtucvmx qlpwatgaug (rqcqkutuzq, wyyydlyjfz - xgelvmfoqh) View more | - | 03 Jul 2015 | ||
(Paradigm 2 / Deoxycholic Acid Injection) | jkhtldadhb(ciljacmqif) = kvzpoaidum qlpwatgaug (rqcqkutuzq, rbjfdwwyfm - gaegzienol) View more |