Research Breakthrough Promises New Lupus Treatments

22 Jul 2024
healthcare-digital.com
ImmunotherapyDrug Approval
The purple ribbon denotes World Lupus Day, May 10.
As study of patients with lupus Lupusers a root cause of the condition we take a deeper look at the autoimmune disease and how it is currently treated
A study of patients with llupushas uncovered a root cause of the disease that may eventually lead toautoimmune diseaseesearchers reported in a study published in Nature.
The immune disorder affeclupusre than 1.5 million people in the US alone, and damages skin, joints, the kidneys, the brain and other organs.
Compimmune disorderples from 19 patients suffering from lupus with healthy people, researchers found that the patients had an imbalance in immune-system cells called ‘T cells’.
There was reduced production of T cells that aid in heallupusand increased production of T cells that produce autoantibodies to attack healthy cells.
In the wake of the study, we take a look at lupus – at its effects and the available treatments.
What is lupus?lupus
Lupus islupusutoimmune disease that causes the body's immune system to attack its own tissues and organs. This condition can affect various parts of the body, including skin, joints, kidneys, brain, heart and lungs. Diagnosis can be complex, as symptoms often mimic those of other ailments. Treatment options for lupus depend on the severity of symptoms and which organs are affected.
Lupusause ofautoimmune diseasenown, but researchers believe it involves a combination of genetic and environmental factors. Women are more likely to develop lupus than men, and it is more prevalent in certain ethnic groups.lupus
Patients withlupuss are advised to protect themselves from sun exposure, as ultraviolet light can trigger flares in some individuals.lupus
How is lupus tlupusd?
Medicatlupusinclude anti-inflammatory drugs, antimalarial drugs and immunosuppressants.
Research has shown antimalarial drugs such as hydroxychloroquine and chloroquine can decrease the frequency and severity of lupus flare-ups. They work by modulating the immune system, which is overactive in lupus patients. This helps reduce inflammation and pain, particularly in the skin and joints.
These medications also help protect the heart,hydroxychloroquineo lowchloroquine of blood clots in lupus patients. This is slupusicant as individuals with lupus have an increased risk of cardiovascular compllupusons.inflammationpain
Antimalarials are used in combination with immunosuppressants for more severe cases.lupuslupus
Antimalarialssants are used to treat lupus because the condition results in the body's immune system mistakenly attacking healthy tissue, causing inflammation and damage to organs including the kidneys, heart and lungs.
Common immunosuppressants used in luplupuseatment include methotrexate, azathioprine, mycophenolate mofetil, and cyclophosphamide. These can be adinflammationrally or intravenously, depending on the specific drug and the patient's condition.
The use of immunosuppressants carrlupusisks, as a suppressmethotrexatestazathioprine pmycophenolate mofetille to cyclophosphamide
Companies that specialise in lupus medicinesinfections
Medications used to treat lupus include anti-inflammatory drugs, antimalarial drugs and immunosuppressants. The following are among the companies that produce treatments in these three categories.
Immunosuppressantslupus
GlaxoSmithKline: Benlysta lupusd on belianti-inflammatory drugs
AstraZeneca: Saphnelo (anifrolumab-fnia)
Eli LilRituxan (rituximab)itinib)
Anti-inflammatories
Janssen Pharmaceuticals: Remicade (infliximab)
Janssen Pharmaceuticalsh Remicade (infliximab) root cause of the disease that may eventually lead to new treatments, researchers reported in a study published in Nature.
UCB iCimziadicertolizumab pegole than 1.5 million people in the US alone, and damages skin, joints, the kidneys, the brain and other organs.
Comparing blood samples flupus9 patients suffering from lupus with healthy people, researchers found that the patients had an imbalance in immune-system cells called ‘T cells’.
Therimmune disorderroduction of T cells that aid in healing, and increased production of T cells that produce autoantibodies to attack healthy cells.
In the wake of the study, we take a look at lupus – at ilupusfects and the available treatments.
What is lupus?
Lupus is an autoimmune disease that causes tlupusdy's immune system to attack its own tissues and organs. This condition can affect various parts of the body, including skin, joints, kidneys, brain, heart and lungs. Diagnosis can be complex, as symptoms often mimic those of other ailments. Treatment options for lupus depend on the severity of symptoms and which organs are affected.
The causlupuslupus remains unknown, but researchers believe it involves a combination of genetic and environmental factors. Women are more likely to develop lupus than men, and it is more prevalent in certain ethnic groups.
Lupusnts witautoimmune diseased to protect themselves from sun exposure, as ultraviolet light can trigger flares in some individuals.lupus
How is lupus lupused?lupus
Medications inlupus anti-inflammatory drugs, antimalarial drugs and immunosuppressants.
Researclupus shown antimalarial drugs such as hydroxychloroquine and chloroquine can decrease the frequency and severity of lupus flare-ups. They work by modulating the immune system, which is overactive in lupus patients. This helps reduce inflammation and pain, particularly in the skin and joints.
These medications also help protect the heart, and are thought to lower the risk of blood clots in lupus patients. This is significant as individuals with lupus have an increased risk of cardiovascular complications.
Antimalarials are used in combination with immhydroxychloroquiner morchloroquineses.lupuslupusinflammationpain
Immunosuppressants are used to treat lupus because the condition results in the body's immune systelupustakenly attacking healthy tissue, causing inflammatlupusnd damage to organs including the kidneys, heart and lungs.
Antimalarialssuppressants used in lupus treatment include methotrexate, azathioprine, mycophenolate mofetil, and cyclophosphamide. These can be administered orally or intravenously, depending on the specific drug and the patient's condition.
The use of immunosuppressants carrieslupuss, as a suppressed immune system makes the patient more susceptible to infections.inflammation
Medications used to treat lupus include anti-inflammatory drugs, antimalarial drugs and immunosuppressants. The finfectionsre among the companies that produce treatments in these three categories.
Immunosuppressants
GlaxoSmithKline: Benlysta (balupusn belimumab)
AstraZeneca: Saphnelo (anilupusmab-fnia)anti-inflammatory drugs
Aurinia Pharmaceuticals: Lupkynis (voclosporin)
Sanofi: PlaOlumianthybaricitinibquine)
Novartis: Ilaris (canakinumab)
UCB: Cimzia (certolizumab pegol)
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