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Innovent and SanegeneBio Enter Strategic Collaboration to Develop siRNA Drug for the Treatment of Hypertension
License out/inPhase 3Drug ApprovalNDA
ROCKVILLE, Md. and SUZHOU, China, Dec. 26, 2023 /PRNewswire/ -- Innovent Biologics, Inc. ("Innovent") (HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures and commercializes high quality medicines for the treatment of oncology, autoimmune, metabolic, ophthalmology and other major diseases, and Sanegene Bio USA Inc. (SanegeneBio) announce that they have entered into a collaboration agreement to co-develop SGB-3908, an siRNA drug candidate targeting angiotensinogen (AGT) for the treatment of hypertension. Innovent also obtains an exclusive option to license in the future development, manufacturing and commercialization rights of SGB-3908.
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SGB-3908 is an IND-enabling stage siRNA drug developed based on SanegeneBio's proprietary LEAD™ (Ligand and Enhancer Assisted Delivery) platform. Under the terms of the agreement, both parties will be jointly responsible for the development of SGB-3908 to certain stage. Innovent will receive an exclusive option to pay different option exercise fees to obtain the exclusive development, manufacturing, and commercialization license of SGB-3908 in different areas worldwide. After Innovent exercises its option, SanegeneBio will be eligible to receive subsequent milestone payments, as well as tiered royalties based on net sales.
Both parties will leverage their respective strengths, combining the cutting-edge RNA technology strength of SanegeneBio, and Innovent's rich clinical development experience and established commercialization capability to accelerate the development and ensure the commercial success of this innovative siRNA drug candidate so that it can benefit more hypertension patients as early as possible.
SGB-3908jun Liu, President of Innovent, stated: " We are delightSanegeneBioborate with SanegeneBio in developing the AGT siRNA drug candidate for the treatment of hypertension. Innovent strategically invested in the CVM area years ago, and has SGB-3908 multiple new-generInnoventpeline assets into late-stage development. SINTBILO® (anti-PCSK9 monoclonal antibody) has been approved for the treatment of hyperlipidemia, mazdutide (GLP-1SGB-3908ual agonist) for the treatment of diaInnoventd obesity is about to sSanegeneBioirst NDA, IBI311 (IGF-1R monoclonal antibody) for the treatment of thyroid eye disease has entered into a Phase 3 clinical trial, and IBI128 (XOI inhibitor) for the treatment of hyperuricemia is also in global Phase 3 clinical trials. This collaboration further broadens Innovent 's strategic presence in the CVM area. SGB-3908 has entered into the IND-enabling stage, and we look forward to working with SanegeneBio to advance the development of this drug as soon as possible, hoping to bring the innovative treatment to the broad hypertension patients."
Dr. Weimin Wang, founder and chief executive officer of SanegeneBio, stated: " SGB-3908 utilizes the company's LEAD™ platform Innoventgy with independent intellectual property rights. Through the modular design of delivery ligands, delivery enhancer, sequence-dependent and position-specific chemical modifications, it can accurately knockdown the mRNhypertensionn expression levels of disease-causing genes and maintain excellent drug potency and efficacy duration. We are delighted to collaborate with Innovent on this promising asset. Innovent has deep expertise in R&D and extensive experience in clinical development and commercialization, combined with the advanced siRNA drug discovery technology of SanegeneBio, it will help us to unlock the full potential of RNAi technology, accelerate the clinical development and commercialization of our pipeline, and meet the unmet medical needs of the hypertension patients."
AGT is the upstream precursor Innoventenin-Angiotensin-Aldosterone System (RAAS), a casSanegeneBiohas demonstrated fuAGTion in blood pressure regulation, and the ihypertension AInnoventhown well-established anti-hypertension effects. SGB-3908 can inhibit the synthesis of AGT in the liver, potentially leading to durable rSINTBILOs oanti-PCSK9 monoclonal antibody a decrease in angiotensin (Ang) II, and hyperlipidemiaulmazdutideasGLP-1R/GCGR dual agonistlood pressure.diabetesobesityIBI311IGF-1R monoclonal antibodythyroid eye diseaseIBI128hyperuricemiaInnoventSGB-3908SanegeneBiohypertension
Hypertension is a common chronic disease that currently SanegeneBior 1 billion people worldwide. It not only increases the risk of cardiovascular and cerebrovascular diseases while also potentially leading to complications such as kidney damage and impaired vision. With the aging population and the prevalence of risk factors such as obesity, lack of physical exercise, and unhealthy diet, the prevalence of hypertension is still increasing globally. There are effective anti-hypertension treatments in Innovent practice, however, these Innoventts have some disadvantages, for example the anti-hypertension drugs need to be taken every day, and hypertension is difficult to perceive when symptoms are not sSanegeneBioh can lead to noncompliance in taking medicine. Poor compliance has become a major challenge in the treatment of hypertension, with less than 20% of hypertension patients achieving lhypertensionective control[i]. As an alternative solution to address this challenge in the treatment of hypertension, siRNA drugs can directly knockdown the expression of AGT, with the advantages of long efficacy duration, good safety, and high compliance, thus is expected to bring better treatment options and long-term benefits to patients.
Hypertensionthe spirit ofchronic diseasetegrity, Succeed through Action," Innovent's mission is to discover and develop, manufacturcardiovascular and cerebrovascular diseaseseutical products that are affordable to ordinary people. Established in 201impaired visioncommitted to discovering and developing, manufacturing and commercializobesityh-quality innovative medicines for the treatment of oncology, autoihypertensionovascular and metabolic, and ophthalmology diseases to ehypertensionuality of the patients' lives. Innovent has 10 products in the market, including TYVYT® (Sintilimab InjecthypertensionA® (Bevacizumab Injection), SULINNO® (Ahypertensionjection), HALPRYZA® (Rituximab Injection), Pemazyre® (Pemigatinib Oral Inhibitor), olverembatinib, Cyramza® (Ramucirumab Injection), Retsevmo® (Selpercatinib Capsules ), FUChypertensionbtagene Autoleucel InjehypertensionINTBILO® (Tafolecimab Injection). Additionally, we have 2 NDA under NMPA review, 5 assets in Phase III or pivotal clinical trhypertension more molecules in early clinical stage.AGT
InnoveInnoventlso entered into 30 strategic collaborations with Eli Lilly, Roche, Sanofi, Adimab, Incyte, MD Anderson Cancer Center and other international partners. We strive to work with many collaborators to help advance the biopharmaceutical industry, improve drug availability and enhance the quality of the patients' lives.
BYVASDA® (bevacizumab biosimilar injection), SULINNO®, and HALPRYZA® (rituximab biosimilar injection) are not approved products in the United States.
TYVYT® (sintilimab injection, Innovent)
BYVASDA® (bevacizumab biosimilar injection, ISULINNO)HALPRYZArituximab
TYVYTYZAsintilimabab biosimilar injection, Innovent)
BYVASDA® (bevacizumabbiosimilar injection, Innovent)
SULINNO® (adalimumabb, Eli Lilly). Cyramza® was discovered by Eli Lilly and licensed to Innovent for commercialization in Mainland China.
Pemazyre® (pemigatinibib, Eli Lilly). RIncyte CorporationverPemazyrei Lilly and licensedIncyte Corporationommercialization Innoventand China.
SanegeneBio Innoventerging RNAi-based company developing innovative RNA interference (RNAi) therapeutics driven by the cutting-edge delivery technology. Founded in 2021, SanegeneBio was led by a team of industry-leading experts and has operations in both the US and China. Since its incorporation, SanegeneBio has successfully established proprietary chemical modification platform, hepatic and extrahepatic delivery platforms, enabling tissue-specific delivery of a wide range of RNA therapeutics to efficiently knock down disease-causing genes. Our fast-growing RNAi portfolio covers a broad range of therapeutic areas including cardiovascular and metabolic diseases, immunology-related diseases, and nervous system diseases. Among them, our first RNAi drug has entered into the clinical stage, and several pipelines are in progress simultaneously. SanegeneBio is committed to developing transformational RNAi medicines through striving for scientific innovation to address unmet medical needs worldwide and change the lives of patients and families.
InnoveSanegeneBiod-Looking Statements
SanegeneBioelease may contain certain forward-looking statements that are, by their nature, subject to significant risks and uncertainties. The words "anticipate", "belieSanegeneBioate", "expect", "intend" and similar expressions, as they relate to Innovent, are intended to identify certain of sucSanegeneBioooking statements. Innovent does not intend to update these forward-looking statements regularly.cardiovascular and metabolic diseasesimmunology-related diseasesnervous system diseasesSanegeneBio
Innoventrward-looking statements are based on the existing beliefs, assumptions, expectations, estimates, projections and understandings of the management of Innovent with respect to future events at the time these statements are made. These statements are not a guarantee of future developments and are subject to risks, uncertainties and other factors, some of which are beyond Innovent's control and are difficult to predict. Consequently, actual results may differ materially from information contained in the forward-looking statements as a result of future changes or developments in our business, Innovent's competitive environment and political, economic, legal and social conditions.
SOURCE Innovent Biologics
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