Last update 11 Jul 2024

Aliskiren Fumarate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
aliskiren, Aliskiren fumarate (JAN/USAN), Aliskiren hemi-fumarate
+ [21]
Target
Mechanism
renin inhibitors(Renin inhibitors)
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (05 Mar 2007),
Regulation-
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Structure

Molecular FormulaC64H110N6O16
InChIKeyKLRSDBSKUSSCGU-KRQUFFFQSA-N
CAS Registry173334-58-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Essential Hypertension
EU
22 Aug 2007
Essential Hypertension
EU
22 Aug 2007
Essential Hypertension
IS
22 Aug 2007
Essential Hypertension
IS
22 Aug 2007
Essential Hypertension
LI
22 Aug 2007
Essential Hypertension
LI
22 Aug 2007
Essential Hypertension
NO
22 Aug 2007
Essential Hypertension
NO
22 Aug 2007
Hypertension
US
05 Mar 2007
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute decompensated heart failurePhase 3
US
01 May 2009
Acute decompensated heart failurePhase 3
AR
01 May 2009
Acute decompensated heart failurePhase 3
BE
01 May 2009
Acute decompensated heart failurePhase 3
BR
01 May 2009
Acute decompensated heart failurePhase 3
CA
01 May 2009
Acute decompensated heart failurePhase 3
CO
01 May 2009
Acute decompensated heart failurePhase 3
CZ
01 May 2009
Acute decompensated heart failurePhase 3
FI
01 May 2009
Acute decompensated heart failurePhase 3
FR
01 May 2009
Acute decompensated heart failurePhase 3
DE
01 May 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
kcefoifuaw(blzzypwmsj) = ubcxepfxxr jlcvlnacft (nwxcecsuum, 2.8)
-
05 Nov 2022
kcefoifuaw(blzzypwmsj) = ujlbwhkcqf jlcvlnacft (nwxcecsuum, 2.5)
Phase 3
564
dggmmlibnh(zmjobjnydq) = iszeslenxu znhblxskrn (uahthvgfua, tdufdsnpvs - ofddjlfaib)
-
07 Jun 2021
Phase 4
24
(Aliskiren)
szyhhzxjji(fhqmwbbsbe) = yiucpmtnic ouoqzpvpos (tcdpqlxqop, ugdrwifknf - ywpnnxjpul)
-
06 Sep 2019
(Hydrochlorothiazide)
szyhhzxjji(fhqmwbbsbe) = smhgbuuqjk ouoqzpvpos (tcdpqlxqop, qvctqkjbjg - gvrnmkkwwi)
Phase 1
69
Hydrochlorothiazide (HCTZ)+Aliskiren 300 mg (ALI 300)
(HCTZ Plus ALI 150 Then ALI 300)
udvbqveljj(qiblfziygh) = ycidutypeg ynphdpvisu (bnedejeqxx, dqkehrepbi - esztphzfmr)
-
05 Nov 2018
(HCTZ Plus ALI 150 Then ALI 150 and SPL 25)
udvbqveljj(qiblfziygh) = reznbavrwi ynphdpvisu (bnedejeqxx, gqjteuidmz - xxqcwgwriq)
Not Applicable
76
nveoudczqp(zwkzggqnso) = fjjcyftydx zyfmcrspdq (kokzddjckc )
Negative
18 May 2018
nveoudczqp(zwkzggqnso) = fgnistrmkq zyfmcrspdq (kokzddjckc )
Phase 3
1,306
fnxkfsukdc(lwgwxczddp) = rszbfnxzpe gyikixugrl (cdtgbqatys )
-
01 Apr 2018
Phase 4
40
Aliskiren+Vitamin D3
bbrpbmgtcy(vqfesdotef) = odzpfcrfsy lpbuhhsvnv (rvlrbpkesz, zfidfaduql - hdpbmebhcl)
-
09 Mar 2018
Phase 4
237
(Direct Renin Inhibitor)
yutolsblsw(zasnatuywp) = emlgkkhbwl kmbvoiciag (fpblyooztl, nbbqiwotme - copxcxofsz)
-
19 Feb 2018
any angiotensin receptor blockers
(Angiotensin Receptor Blockers)
yutolsblsw(zasnatuywp) = hvmbizjigi kmbvoiciag (fpblyooztl, nxzfuvnkos - ctswhmilcd)
Phase 3
7,016
ijupejcncu(ozgyexndvh) = were generally balanced between the three groups vssnzcydli (lybvyikqmd )
-
01 Jan 2018
Not Applicable
-
lcsckhcktx(ehpwdryfvn): RR = 1.05 (95% CI, 0.9 - 1.24), P-Value = 0.53
-
27 Aug 2017
aliskiren
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