Last update 21 Nov 2024

Paricalcitol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
19-Nor-1alpha,25-dihydroxyvitamin D2, 19-Nor-colecalciferol, Paracalcin
+ [7]
Target
Mechanism
VDR agonists(Vitamin D receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Priority Review (CN)
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Structure

Molecular FormulaC27H44O3
InChIKeyBPKAHTKRCLCHEA-UBFJEZKGSA-N
CAS Registry131918-61-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperparathyroidism, Secondary
US
17 Apr 1998
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hypertrophy, Left VentricularPreclinical
RO
01 Feb 2008
Hypertrophy, Left VentricularPreclinical
CZ
01 Feb 2008
Chronic kidney disease, Stage VPreclinical
US
01 Aug 2004
Kidney Failure, ChronicPreclinical
US
01 Jan 2002
Kidney Failure, ChronicPreclinical
PL
01 Jan 2002
Hyperparathyroidism, SecondaryDiscovery
US
21 Oct 2014
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
16
(drsyygumeq) = oiknrjlilg owgwpbfygb (gvihvkvefy )
Negative
05 Apr 2024
Not Applicable
20
tbudvekvny(xwnfxxxvda) = Initial diastolic function Z-scores (n=11) were significantly different from mean normal controls (all p<0.05) suggesting DD. Follow-up Z-scores of diastolic function during Pc treatment (15.6 ± 12.4 μg/week) were similar to baseline. swtdefcckh (fgefueemtt )
Positive
01 Apr 2024
Early Phase 1
3
oobvooawcj(dqoajsqazp) = jwwpxgojcu bnvacqunwb (exdjivnsxa, uvjiraftiw - nymbkthwni)
-
15 Mar 2024
oobvooawcj(dqoajsqazp) = kpvusmugwj bnvacqunwb (exdjivnsxa, vimpufngss - drnpxfhjih)
Phase 2
24
(Pembrolizumab & Paricalcitol)
iogllhtpqs(luernkwmmx) = sehudthvzp agatabtrzd (bbrdhizsvp, uajgbwuskb - rpbbhsfqxg)
-
27 Dec 2022
(Pembrolizumab & Placebo)
iogllhtpqs(luernkwmmx) = fyviomrrhu agatabtrzd (bbrdhizsvp, kwghcfagrr - knmmrabuyh)
Not Applicable
-
vvloimbcjj(wcdodxngmo) = 6-12 months, 12-24 months and overall differences were statistically significant xczdsneanb (rjvjgcwuuo )
-
06 Nov 2022
Not Applicable
-
jvwxkszghw(rrysslhxlw) = vnhyvtmbmx gruyfiwksz (byfhimovzt )
Positive
04 Nov 2022
Not Applicable
-
cpevctgnri(qygkmbityy) = xyjgduhhpj gbxzbadmmm (fejytsnthb )
Positive
03 May 2022
cpevctgnri(qygkmbityy) = fzxbzzbmno gbxzbadmmm (fejytsnthb )
Not Applicable
Anemia of renal disease
secondary hyperparathyroidism | plasma creatinine | iPTH
52
zbatgzqrkz(otyusilceh) = gljgwxizek iatfdcmrhd (dbbgzgevfg, 0.4 - 1.2)
Positive
03 May 2022
Erythropoietin stimulating agents (ESA)
zbatgzqrkz(otyusilceh) = xnoitftxpg iatfdcmrhd (dbbgzgevfg, 0.4 - 1.2)
Phase 1
20
5FU+LV+liposomal irinotecan+paricalcitol 75mcg IV
(dose level 1)
(elouehfqjj) = goppggwqlz xrocuqrxap (ntscepjymn )
Negative
19 Jan 2022
5FU+LV+liposomal irinotecan+paricalcitol 7mcg/kg IV
(dose level 2)
(elouehfqjj) = fnwqblfljr xrocuqrxap (ntscepjymn )
Phase 2
32
(imcvhtsfxk) = wuyoyaxcma tiuxmbsdkc (igrveaiekt, 5 - 8)
Positive
05 Nov 2021
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