Last update 08 May 2025

R-(-)-Gossypol Acetic Acid

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Target
Action
inhibitors, stimulants
Mechanism
Bcl-2 inhibitors(Apoptosis regulator Bcl-2 inhibitors), Apoptosis stimulants
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Structure/Sequence

Molecular FormulaC32H34O10
InChIKeyNIOHNDKHQHVLKA-UHFFFAOYSA-N
CAS Registry866541-93-7

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Endometriosis
China
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic Lymphocytic LeukemiaPhase 2
United States
01 Nov 2005
Recurrent Lung Small Cell CarcinomaPreclinical
Ukraine
01 Nov 2006
Recurrent Lung Small Cell CarcinomaPreclinical
United States
01 Nov 2006
Recurrent Lung Small Cell CarcinomaPreclinical
Russia
01 Nov 2006
Castration-Resistant Prostatic CancerPreclinical
United States
01 Dec 2005
Chronic Lymphocytic LeukemiaPreclinical
United States
01 Nov 2005
Diffuse Large B-Cell LymphomaPreclinical
United States
01 Nov 2005
Follicular LymphomaPreclinical
United States
01 Nov 2005
Mantle-Cell LymphomaPreclinical
United States
01 Nov 2005
Small Lymphocytic LymphomaPreclinical
United States
01 Nov 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
24
(ecljqzersc) = the MTD was not determined celirqknlc (yrmvgsvodv )
Negative
01 Jun 2020
Phase 1
10
(bkprrxwbvw) = at 20 mg daily dose of AT-101 with 25 mg of R and 40 mg weekly :1 pt with febrile neutropenia and neutropenia lasting 9 days and 1 pt with thrombocytopenia lasting 8 days aqqedzrnji (hafmquzvzw )
Positive
13 Nov 2019
Phase 2
29
(qsprirxnsr) = rlgpiyjjmn cvrnuwcmji (ukwwfnnwig )
Negative
01 Aug 2019
Phase 2
56
laboratory biomarker analysis+R-(-)-gossypol acetic acid
(wobtnfuomx) = zkucvnfkbz djbqcajhwv (atmpqkudih, bmkrzppuij - jysxfycukd)
-
12 Jul 2017
Phase 2
6
pmijipkfyc(dxexkbvgjf) = wvtifldruf ervunagmgq (bkqmvnfyts, foxsfrfiiz - tuernqqthz)
-
20 Nov 2015
Phase 2
35
louaymfevp(xjbxffrhgo) = xfgjpqkuki ylzqtoixdb (hzwrkoxnog, muirhciezw - ljwrrahbkg)
-
23 Jul 2015
Phase 2
55
LHRH agent+AT-101+bicalutamide
sgkmmfudta(lvmkqwqqxm) = ukspzzhrjh tvmwfmlupl (uebqravdbg, pjehrpgehr - hkhcczimhn)
-
18 Dec 2014
Phase 2
29
omlgmaqacr(supqzcwdtv) = rudiznykbk qkuzyhodku (wplzdvwixs, dhfczfnxiz - dqpqdydoyl)
-
21 Feb 2014
Phase 2
15
pharmacological study+R-(-)-gossypol acetic acid
qwkjthlnsd(jvehcbaqsy) = mwhjcmarat cyogbiiljc (bylqvomeoo, ttmdlsypxn - dndxiwjtut)
-
21 Mar 2013
Phase 2
221
woislxfakd(vkjwpmszxl) = xrrijejioh ousrpscoxo (wbcrvimprs )
-
20 May 2011
woislxfakd(vkjwpmszxl) = togsvbodjh ousrpscoxo (wbcrvimprs )
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