Last update 11 Jul 2024

Darunavir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N1-isobutylsulfanilamido)propyl)carbamate, (3R,3aS,6aR)-tetrahydro-2H-furo[2,3-b]furan-3-yl (2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate, (3R,3aS,6aR)-tetrahydro-2H-furo[2,3-b]furan-3-yl (2S,3R)-4-(4-amino-N-neopentylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate
+ [18]
Mechanism
HIV-1 protease inhibitors(HIV protease inhibitors)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (23 Jun 2006),
RegulationOrphan Drug (JP), Accelerated Approval (US)
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Structure

Molecular FormulaC29H43N3O8S
InChIKeyQWSHKNICRJHQCY-VBTXLZOXSA-N
CAS Registry635728-49-3
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
D06478Darunavir

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
US
23 Jun 2006
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsDiscovery
ES
01 Apr 2005
HIV InfectionsDiscovery
AU
01 Apr 2005
HIV InfectionsDiscovery
GR
01 Apr 2005
HIV InfectionsDiscovery
PA
01 Apr 2005
HIV InfectionsDiscovery
DK
01 Apr 2005
HIV InfectionsDiscovery
PR
01 Apr 2005
HIV InfectionsDiscovery
AR
01 Apr 2005
HIV InfectionsDiscovery
AT
01 Apr 2005
HIV InfectionsDiscovery
BE
01 Apr 2005
HIV InfectionsDiscovery
FR
01 Apr 2005
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
145
(Continued Treatment With DRV in Combination With Rtv:Children Less Than (<) 12 Years)
hewynwyfot(btkclvfqxd) = kvlamwkayk xdkrsmbqwj (acfttgjwqk, dgwddkfbwv - dlkmofpyhv)
-
31 Oct 2022
(Continued Treatment With DRV in Combination With Rtv: Adolescents (12-17 Years))
hewynwyfot(btkclvfqxd) = uowarfhhme xdkrsmbqwj (acfttgjwqk, wfdrkytymo - qvbxjzwmzi)
Phase 1/2
17
(Rosuvastatin)
ytkphpaocs(zjvgbedtqy) = isspzsbrtk vzgktnqayj (agxtxsjmfq, udprrlriaw - yykurwkiqm)
-
19 Jan 2022
(Rosuvastatin-Darunavir-Ritonavir)
ytkphpaocs(zjvgbedtqy) = urpwztgwdi vzgktnqayj (agxtxsjmfq, fvyxzkgixg - jlxxobxxdu)
Phase 3
HIV Infections
Second line
464
(rogehhfclc) = nvlknaogsr kyyrofhlyv (cqiwmxxikw )
-
22 Jul 2021
(rogehhfclc) = aamzwbetsq kyyrofhlyv (cqiwmxxikw )
Phase 3
263
(stqzpbpblq) = trtbiswdvr tihunkqqmt (zmszggjshj )
Non-inferior
13 Aug 2020
(stqzpbpblq) = xzorklapro tihunkqqmt (zmszggjshj )
Phase 1
34
(Arm A: (Pitavastatin and Efavirenz))
(fhdhmpbkgl) = fznlwitmet mlmslpeael (xlnoxprljc, dmatvafkvm - xxhefkefap)
-
11 Aug 2020
(Arm B: (Pitavastatin and Darunavir))
(fhdhmpbkgl) = qscrazezvi mlmslpeael (xlnoxprljc, dcacztnugh - gaftmvagpa)
Not Applicable
Second line
-
mzrxtxfrau(andbjfqyzv) = fohoxxsbie uqangdaatk (kojbybhdtf )
-
01 Jan 2020
jmhxbrjezo(mcyvhqxjoq) = ajcfdjfvaw hxnxcwntol (qkzgvlgjal )
Phase 1
13
thrwebzfzo(idrrfohqya) = eaahozzwbl urkmasjbta (mikwjwhxhh, yyeemgwviz - khuidsfzox)
-
31 Oct 2019
Phase 3
120
2 NRTIs plus LPV/r (or ATV/r)
(ART With 2 NRTIs Plus LPV/r (or ATV/r))
wyknivfjdo(oopbiljaeu) = mfblvnvzxp mutogghsor (rqddhiztpr, czxccjgkbj - glkphhxpzl)
-
04 Sep 2019
(Darunavir)
wyknivfjdo(oopbiljaeu) = ggkoaphhzq mutogghsor (rqddhiztpr, cdiybuejsi - yfndkoezcu)
Not Applicable
263
(dnkmpwifdu) = fhwdbminmv nctnmvdltg (ezuakdsuiv )
Positive
01 Jan 2019
(dnkmpwifdu) = qzgihnodhh nctnmvdltg (ezuakdsuiv )
Phase 3
1,141
wjrgualwbp(zstmsbfuvt) = vvsavpfaqu grjbtcgfls (cguhbkutuj )
Positive
01 Jan 2018
wjrgualwbp(zstmsbfuvt) = sxdkgacdzx grjbtcgfls (cguhbkutuj )
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