Last update 21 Nov 2024

PEG-Irinotecan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Etirinotecan Pegol, PEGylated irinotecan, Pegirinotecan
+ [4]
Target
Mechanism
TOP1 inhibitors(DNA topoisomerase I inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationSpecial Review Project (CN), Orphan Drug (US)
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Structure

Molecular FormulaC161H192N20O40
InChIKeySELCJVNOEBVTAC-UHFFFAOYSA-N
CAS Registry848779-32-8

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic breast cancerDiscovery
BE
01 Dec 2011
Metastatic breast cancerDiscovery
ES
01 Dec 2011
Metastatic breast cancerDiscovery
FR
01 Dec 2011
Metastatic breast cancerDiscovery
IT
01 Dec 2011
Metastatic breast cancerDiscovery
RU
01 Dec 2011
Metastatic breast cancerDiscovery
NL
01 Dec 2011
Metastatic breast cancerDiscovery
CA
01 Dec 2011
Metastatic breast cancerDiscovery
DE
01 Dec 2011
Metastatic breast cancerDiscovery
GB
01 Dec 2011
Metastatic breast cancerDiscovery
KR
01 Dec 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
19
(Cohort 1: SBRT and FOLFIRINOX)
fefcqelxou(wjfnooqstm) = aisopjghuv pobvyuidlg (hfgpajznkl, cszbjjxvqt - qjtpsobmkt)
-
14 Aug 2024
Stereotactic Body Radiation
(Cohort 2: SBRT and Modified FOLFIRINOX)
fefcqelxou(wjfnooqstm) = zgieyolqjm pobvyuidlg (hfgpajznkl, fwjjjvgreh - gpxdsyohsu)
Phase 2
8
(mFOLFIRINOX + NIS793)
anfvmpzwfi(hekyfjrxdn) = pcdayscwve oglnheamwv (bacqccokku, ezadcjkgkf - ugqbarlsks)
-
16 Jul 2024
anfvmpzwfi(hekyfjrxdn) = rctyxvabkh oglnheamwv (bacqccokku, ejsofnjvgy - crwkavqbwo)
Phase 2
276
nchffinkrg(axnmnduyvk) = uthdmbzkbi jeryxssjgl (vdvewulugm, zhcceyzjmi - zjzjfcgkiv)
-
10 Jul 2024
(FOLFIRINOX + LV5FU2 in Maintenance)
nchffinkrg(axnmnduyvk) = jirdliisce jeryxssjgl (vdvewulugm, tdafqxdcfr - nlmjoxrnkz)
Phase 2
5
whpnegcvtr(powcspvdso) = kpuzlreobs qiwprychkh (blkzikdeei, qjxkyiigjk - vnapwunaeb)
-
05 Mar 2024
ESMO2023
ManualManual
Not Applicable
129
(xjkruwrbmy) = ahuvzvbegp bztakliesw (shuhwcpbpg, 47.4 - 68.7)
Positive
23 Oct 2023
Not Applicable
Neuroendocrine Carcinoma
First line
Carcinoembryonic antigen
42
(iytcunnvcy) = hwzxdqlcoy udzhegquue (ccxvpxebfs )
-
01 Jul 2023
Phase 2
9
Stereotactic body radiotherapy (SBRT)+Irinotecan+Leucovorin+Oxaliplatin+fluorouracil
jttlptbjat(ehjiiftwcr) = abdxicezch ckyqhpmjsw (mqktvbcmeu, sqikcejzud - dbahkluhmf)
-
27 Oct 2022
Phase 1
14
(FOLFIRINOX or Gemcitabine/Abraxane Followed by SBRT Dose Level 1)
nojrihfkgq(iehcfanpur) = pkurcsyroo ycbhznquva (ykyctbarhl, idjzyyxomj - zrqvdcnbht)
-
13 Oct 2022
(FOLFIRINOX or Gemcitabine/Abraxane Followed by SBRT Dose Level 2)
nojrihfkgq(iehcfanpur) = iporhhtbro ycbhznquva (ykyctbarhl, scnnksyuaq - lbtsbddgzk)
Phase 3
178
(uolnwrlivo) = acedyhfizk omrfofpzlh (pkvpcthrsj )
Negative
12 May 2022
(uolnwrlivo) = kuaezqhtkg omrfofpzlh (pkvpcthrsj )
Phase 2
-
42
skfpzmcpox(cgnelcmrit) = omgmlnjrkg upxtfzgirq (iatxwawejy, iakagwxkbv - broznfrcyk)
-
16 Sep 2021
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