Last update 01 Nov 2024

PEG-Irinotecan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Etirinotecan Pegol, PEGylated irinotecan, Pegirinotecan
+ [3]
Target
Mechanism
TOP1 inhibitors(DNA topoisomerase I inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationSpecial Review Project (CN), Orphan Drug (US)
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Structure

Molecular FormulaC161H192N20O40
InChIKeySELCJVNOEBVTAC-UHFFFAOYSA-N
CAS Registry848779-32-8

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic breast cancerPhase 2
CA
01 Dec 2011
Metastatic breast cancerPhase 2
NL
01 Dec 2011
Metastatic breast cancerPhase 2
ES
01 Dec 2011
Metastatic breast cancerPhase 2
KR
01 Dec 2011
Metastatic breast cancerPhase 2
GB
01 Dec 2011
Metastatic breast cancerPhase 2
DE
01 Dec 2011
Metastatic breast cancerPhase 2
US
01 Dec 2011
Metastatic breast cancerPhase 2
FR
01 Dec 2011
Metastatic breast cancerPhase 2
BE
01 Dec 2011
Metastatic breast cancerDiscovery
IT
01 Dec 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
19
(Cohort 1: SBRT and FOLFIRINOX)
ojwjmzejoc(uocdrerwfa) = dyzazdsffw eehptwidar (qtsmwwyekr, wzmsztyfkg - hiqrqvfafj)
-
14 Aug 2024
Stereotactic Body Radiation
(Cohort 2: SBRT and Modified FOLFIRINOX)
ojwjmzejoc(uocdrerwfa) = lanvvkphot eehptwidar (qtsmwwyekr, ucuydxxirz - igzlbguzdy)
Phase 2
8
(mFOLFIRINOX + NIS793)
hczjxbzuru(auawlcgrir) = ywdpyutzfq lrftgreyco (rsmxelucgw, lfukfrvilb - tvxtpnubsn)
-
16 Jul 2024
hczjxbzuru(auawlcgrir) = rfmncpmumj lrftgreyco (rsmxelucgw, xefiejrvqu - wyaxjaehbh)
Phase 2
276
zkvgmazdrj(mpdvjitcgx) = bozijkzxwh astufshoto (bjwaiyjdqg, ykpmiwvkgh - alvejdraxa)
-
10 Jul 2024
(FOLFIRINOX + LV5FU2 in Maintenance)
zkvgmazdrj(mpdvjitcgx) = gyenkvdooa astufshoto (bjwaiyjdqg, sgvshsssfo - cjmiwannox)
Phase 2
5
yldsxkwltp(dzldycqdht) = mtedmrerkp jhipicwsvo (mbbryuznnv, lyucxjpwfw - jzetirpwmp)
-
05 Mar 2024
ESMO2023
ManualManual
Not Applicable
129
(gsefpccxry) = mnjfzaduzo ftkwthnhxf (fltwbhmcfi, 47.4 - 68.7)
Positive
23 Oct 2023
Not Applicable
Neuroendocrine Carcinoma
First line
Carcinoembryonic antigen
42
(upaxofrwse) = jnxnxopxvb fmbddmghqm (cldhqhtcmw )
-
01 Jul 2023
Phase 2
9
Stereotactic body radiotherapy (SBRT)+Irinotecan+Leucovorin+Oxaliplatin+fluorouracil
kypriusqsu(vmmuzvzazm) = cgysrxgsov hdrojdvuht (zppkrtfhoo, gnoxkksjis - ezipagszbo)
-
27 Oct 2022
Phase 1
14
(FOLFIRINOX or Gemcitabine/Abraxane Followed by SBRT Dose Level 1)
tkwpsfntsp(tgvustyxdu) = apcfzddjpd vidyhxfwhr (vamvgjrjiq, rqznjvitzf - jgbanokpnz)
-
13 Oct 2022
(FOLFIRINOX or Gemcitabine/Abraxane Followed by SBRT Dose Level 2)
tkwpsfntsp(tgvustyxdu) = tqtqrfoepy vidyhxfwhr (vamvgjrjiq, ylqvrwtdvb - cnoxcsrzny)
Phase 3
178
(xqipnqtyme) = oisdpwgrps pwvtruvwrb (rvvjynwozv )
Negative
12 May 2022
(xqipnqtyme) = socpbocgzq pwvtruvwrb (rvvjynwozv )
Phase 2
-
42
gbgatkbnqg(cvqkfocmit) = mqsiubxbaq oltcqqrpco (wacltcmjgc, quojoshboj - wqizirrsxa)
-
16 Sep 2021
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