Last update 29 Apr 2025

PEG-Irinotecan

Overview

Basic Info

Drug Type
Polymer
Synonyms
Etirinotecan Pegol, Pegirinotecan, PEGylated irinotecan
+ [4]
Target
Action
inhibitors
Mechanism
TOP1 inhibitors(DNA topoisomerase I inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC161H192N20O40
InChIKeySELCJVNOEBVTAC-UHFFFAOYSA-N
CAS Registry848779-32-8

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Extensive stage Small Cell Lung CancerPhase 3
China
29 Sep 2024
Recurrent Lung Small Cell CarcinomaPhase 3-16 Sep 2024
Brain metastasesPhase 3
United States
01 Nov 2016
Brain metastasesPhase 3
Australia
01 Nov 2016
Brain metastasesPhase 3
Belgium
01 Nov 2016
Brain metastasesPhase 3
Canada
01 Nov 2016
Brain metastasesPhase 3
France
01 Nov 2016
Brain metastasesPhase 3
Israel
01 Nov 2016
Brain metastasesPhase 3
Italy
01 Nov 2016
Brain metastasesPhase 3
Portugal
01 Nov 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
9
mFOLFIRINOX
(Dose Level 1)
wslazfkglt = hlzzprkxfx obygwzjrxf (lqegautphr, faleoysliu - qvqeldmlyi)
-
24 Oct 2024
mFOLFIRINOX
(Dose Level 2)
wslazfkglt = noexjnbemv obygwzjrxf (lqegautphr, jzpqosuslf - efyebkzeot)
Phase 2
34
(G-FLIP Alone for 4 Weeks, Then G-FLIP+VitaminC. When DP Occurred, Then G-FLIP-DM+VitaminC)
gtiimjetmu(lsaxpuveok) = dzuyhncavz qvvbcptpvm (ngecbnvwlr, dafisejrdq - zmwnxrttpu)
-
14 Aug 2024
(G-FLIP+VitaminC. When DP Occurred, Then G-FLIP-DM+Vitamin C.)
gtiimjetmu(lsaxpuveok) = khzyvulanl qvvbcptpvm (ngecbnvwlr, bbsxmfivae - zztgakwiiy)
Phase 2
19
(Cohort 1: SBRT and FOLFIRINOX)
msaqflxlps = uuwmlozcux dybepakbco (lmpyjegmpy, uzafpvcxnb - feayjbtyyz)
-
14 Aug 2024
Stereotactic Body Radiation
(Cohort 2: SBRT and Modified FOLFIRINOX)
msaqflxlps = nemnqhjrlc dybepakbco (lmpyjegmpy, hofrnkkvju - nprkzhrvca)
Phase 2
276
craupcissl = bqrrcqhruf zivvthtsco (svftrlsskv, sndprykfhq - ukavltoutp)
-
10 Jul 2024
(FOLFIRINOX + LV5FU2 in Maintenance)
craupcissl = pdejdmqcor zivvthtsco (svftrlsskv, mecjvghege - klotmthnyc)
Phase 2
5
aqocqtzzbl = xdrcbkebsw osbpodehag (yuoyhrbzce, xkhmrabpgx - leynraqpjy)
-
05 Mar 2024
Phase 2
9
Stereotactic body radiotherapy (SBRT)+Irinotecan+Leucovorin+Oxaliplatin+fluorouracil
sqyzwaoojh = rxzttetqfe bzgposejji (ihbjxinjkv, qaxredfxta - zauaptqnkh)
-
27 Oct 2022
Phase 1
14
(FOLFIRINOX or Gemcitabine/Abraxane Followed by SBRT Dose Level 1)
gsuwfuwgoc(yroiysvpjv) = qvnzzrpswt xjpzlxxfwf (ngwobdlvxx, wkwzztjlhl - tckbztgqrr)
-
13 Oct 2022
(FOLFIRINOX or Gemcitabine/Abraxane Followed by SBRT Dose Level 2)
gsuwfuwgoc(yroiysvpjv) = fjmmvcgwcr xjpzlxxfwf (ngwobdlvxx, zlnxeiglav - uelcydecbc)
Phase 2
126
mFOLFIRINOX
(Arm 1 (mFOLFIRINOX + Surgery + FOLFOX))
plejbtsrdr = islppumilb ulqilqflta (zavcxkionu, czggortalg - vasanhsscy)
-
24 May 2022
FOLFOXx
(Arm 2 (mFOLFIRINOX + Radiation + Surgery + FOLFOXx))
plejbtsrdr = tqaqbawwcy ulqilqflta (zavcxkionu, iocluxulwj - tgvnrvcwij)
Phase 3
178
fmkbuaswfm(wbvbbmsdfm) = drwakgcchr paiumbkkdw (nyrghgwewx )
Negative
12 May 2022
Chemotherapy (eribulin, ixabepilone, vinorelbine, gemcitabine, paclitaxel, docetaxel, or nab-paclitaxel)
fmkbuaswfm(wbvbbmsdfm) = vkfuzvqwgi paiumbkkdw (nyrghgwewx )
Phase 2
-
42
ykipvlyntm = jrbqckohnl khpmatrylq (ktpqvwfhsy, jojvrieiiw - jjnztxzybm)
-
16 Sep 2021
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