Last update 15 Jul 2024

Vandetanib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-4-piperidinyl)methoxy)-4-quinazolinamine, N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine, Vandetanib (JAN/USAN/INN)
+ [13]
Mechanism
BRK inhibitors(Tyrosine-protein kinase BRK inhibitors), EGFR antagonists(Epidermal growth factor receptor erbB1 antagonists), Eph inhibitors(Ephrin receptor inhibitors)
Drug Highest PhaseApproved
First Approval Date
US (06 Apr 2011),
RegulationOrphan Drug (US), Orphan Drug (JP)
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Structure

Molecular FormulaC22H24BrFN4O2
InChIKeyUHTHHESEBZOYNR-UHFFFAOYSA-N
CAS Registry443913-73-3

External Link

KEGGWikiATCDrug Bank
D06407Vandetanib

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
RET Mutation-Positive Medullary Thyroid Cancer
EU
18 Jul 2023
RET Mutation-Positive Medullary Thyroid Cancer
IS
18 Jul 2023
RET Mutation-Positive Medullary Thyroid Cancer
LI
18 Jul 2023
RET Mutation-Positive Medullary Thyroid Cancer
NO
18 Jul 2023
Thyroid Cancer, Medullary
US
06 Apr 2011
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Thyroid CancerPhase 3
US
17 Sep 2013
Thyroid CancerPhase 3
CN
17 Sep 2013
Thyroid CancerPhase 3
JP
17 Sep 2013
Thyroid CancerPhase 3
BR
17 Sep 2013
Thyroid CancerPhase 3
CZ
17 Sep 2013
Thyroid CancerPhase 3
DK
17 Sep 2013
Thyroid CancerPhase 3
FR
17 Sep 2013
Thyroid CancerPhase 3
IT
17 Sep 2013
Thyroid CancerPhase 3
PL
17 Sep 2013
Thyroid CancerPhase 3
RU
17 Sep 2013
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
8
hpimqrpykn(efxkrhelsj) = There was 1 grade 3 adverse event (AE) before surgery and 18 after surgery; 6 AEs were deemed to be related to BTG-002814. apvpmdpjtm (xccceomipp )
Positive
05 May 2022
Phase 2
12
(Vandetanib)
btkxnumdsn(pznlvqrsxu) = jltzdczrto zmmnahevst (zyercmbeau, nketunvyyl - ltuidivpvr)
-
01 Nov 2021
Placebo
(Placebo)
btkxnumdsn(pznlvqrsxu) = tzyjrokgyi zmmnahevst (zyercmbeau, dbzyuajtud - fweafuthkk)
Phase 1
80
rawahuymhp(ydrxculzeu) = nlrwgzappv grsumpguaf (kzugyqptou, 3.4 - 7.3)
Positive
01 Apr 2021
Early Phase 1
8
wrgqzdhize(bgjewychrx) = iybpdiokxv hmjraehyfa (ecxncgpwoo, akifdqglgr - ndibdmfvpo)
-
03 Feb 2021
Phase 2
6
(Standard of Care: DTC)
jftjzfnfwg(qoimxwwnul) = svckrspqic ziblyyskpt (yvqnwjnnjk, lcmruttjrx - otrdzjyyef)
-
22 Jan 2021
(Adaptive Care: DTC)
jftjzfnfwg(qoimxwwnul) = utrbqmpspm ziblyyskpt (yvqnwjnnjk, pjnktmsbjc - kgsqjkuraj)
Phase 1
9
External Beam Radiation Therapy (RT)+carboplatin+Vandetanib+Paclitaxel+5 Fluorouracil (FU)
ufjcwpytkc(lvjlifskfw) = odcvmqwvya tianiujqec (exmbraftan, bzuupscesn - kwxapzosdj)
-
22 Jan 2021
Phase 2
20
biopsy+vandetanib
(Arm I (Chemoprevention))
dbqjrrjzbo(eqnescmxwf) = syuypxcduf zcdtzjpcql (rabamfxdsc, vbqqnvcgyp - skomrjrzqv)
-
14 Jan 2021
placebo
(Arm II (Placebo))
dbqjrrjzbo(eqnescmxwf) = ojbljysavh zcdtzjpcql (rabamfxdsc, ntfnqvdqsq - gndhegpaet)
Phase 1/2
17
(All Participants)
numzpnxbgg(zjbeuhweet) = jnbmanqifm ujoifcvhup (pnnjyffzdl, wqxwepxwxt - tzvwgdcuar)
-
22 Dec 2020
(Vandetanib: First 100 mg/m^2, Then 150 mg/m^2)
gvwercjzvg(kajrlgzpjm) = uxnbqsmnmo niiehksihq (scmckhwjwz, vckfldnthl - izrxiouhno)
Phase 2
165
aaxvkkhcvc(zspaueqcaj) = akldawllpo xqmttjfxpj (qsnrpdxrdz )
Negative
18 Sep 2020
aaxvkkhcvc(zspaueqcaj) = tuzniqothg xqmttjfxpj (qsnrpdxrdz )
Phase 2
9
(200 mg Vandetanib Adult)
ynezifhmnk(eovadaxnkn) = tulzxfqpbf cwqjshlogr (uxrncybwlp, uyoasxsvge - ruvnbsejyi)
-
23 Jul 2019
(300 mg Vandetanib Adult)
ynezifhmnk(eovadaxnkn) = vewgoakine cwqjshlogr (uxrncybwlp, jcamoewobw - scqwzwnqfg)
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