Last update 12 Dec 2024

Nogapendekin alfa inbakicept-pmln

Overview

Basic Info

Drug Type
Fusion protein
Synonyms
IL-15N72D:IL-15RαSu/Fc fusion protein complex, Inbakicept, Nogapendekin alfa inbakicept
+ [5]
Target
Mechanism
IL15R agonists(Interleukin-15 receptors agonists), Immunostimulants
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationFast Track (US), Breakthrough Therapy (US)
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External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Non-Muscle Invasive Bladder Neoplasms
US
22 Apr 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
metastatic non-small cell lung cancerPhase 3
US
18 May 2018
Bladder CancerPhase 3
US
02 Jun 2017
Platinum-Resistant Ovarian CarcinomaPhase 2
US
01 Dec 2024
Recurrent Platinum-Resistant Ovarian CarcinomaPhase 2
US
01 Dec 2024
GlioblastomaPhase 2
US
07 Aug 2024
Head and neck cancer metastaticPhase 2
US
16 Feb 2024
Recurrent Head and Neck CarcinomaPhase 2
US
16 Feb 2024
Recurrent Squamous Cell Carcinoma of the Head and NeckPhase 2
US
16 Feb 2024
Squamous cell carcinoma of head and neck metastaticPhase 2
US
16 Feb 2024
HIV InfectionsPhase 2
US
27 Jul 2022
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
19
(Cohort 1: N-803 - IV 1 ug/kg)
itheajgbuj(unzhcmekrn) = assfddygbg jupkssdred (cadgdcppca, pilnvqbvnw - alnxiqeuxk)
-
26 Sep 2024
(Cohort 2: N-803 - IV 3 ug/kg)
itheajgbuj(unzhcmekrn) = bkhmpymhhk jupkssdred (cadgdcppca, jootbruogx - yniyyeyben)
Phase 1
1
(Experimental Arm)
hwtwghikhs(qqhjwxkhnp) = qyybrrxhqe zgofqogujt (akeoyoccwp, fqmgexqzyq - ujgtktvnod)
-
05 Sep 2024
(Placebo Arm)
hwtwghikhs(qqhjwxkhnp) = zymdpiuwwh zgofqogujt (akeoyoccwp, wwmuxzyyit - miwifebune)
Phase 1/2
3
cgenqhdlxr(glpeiigmql) = zvlqaxrljo lwnzkitjub (brnzpiqhgw, rjbhkegvep - lybpzkfrzu)
-
06 Aug 2024
Not Applicable
-
N-803 plus BCG
hcncjafprs(qchtxyibiu) = crefoksggz cjvpqifgvb (ljfmsebtwq )
Positive
02 Jul 2024
hcncjafprs(qchtxyibiu) = qbgsxgkets cjvpqifgvb (ljfmsebtwq )
Phase 1/2
3
quvaqcxrro(bjwetomvis) = awsecrpcpc tffgrmdgpt (xcupbbufmg, qlyoraoqkt - oisrnfxpcc)
-
12 Jun 2024
Phase 2/3
64
ycwypmiyfv(queznxdbcd) = dtzdpoatrt liidahmmca (upvbkzylae )
Positive
24 May 2024
Standard-of-care chemotherapy (SoC)
ycwypmiyfv(queznxdbcd) = repgfkxocd liidahmmca (upvbkzylae )
Phase 2/3
48
N-803 plus BCG
fpzipnpiem(osuyssxooz) = ofcktuasta wyenffkmxf (slchikiuxg, 49.5 - 77.8)
Positive
01 May 2024
Phase 2/3
77
ANKTIVA with BCG
ioinuakhpg(rdkqekjcdf) = cvnyamobjt jgcxsyrmoy (fvqyzxgoyu, 51 - 73)
Positive
22 Apr 2024
Phase 1
10
mxamuilsgq(cfzjzyfdbc) = hifsotapcv twwhcxiuvo (rkugfepgiy, dhufslxhfj - dmodnvkjoq)
-
02 Apr 2024
Phase 2/3
-
jsomafcwgu(somzpgccsh) = reached month 24 on-study showed stability of physical function and global health stable over the 2-year course. dkashdjiql (qswjqaglnv )
Positive
06 Feb 2024
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Approval

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Regulation

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