Last update 28 May 2025

Tagraxofusp-ERZS

Overview

Basic Info

Drug Type
Fusion protein
Synonyms
Diphtheria toxin-il-3 fusion protein targeting IL-3 receptor, Diphtheria-toxin-interleukin-3-fusion-protein, Tagraxofusp
+ [8]
Target
Action
inhibitors
Mechanism
CD123 inhibitors(Interleukin-3 receptor subunit alpha inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationBreakthrough Therapy (United States), Orphan Drug (United States), Orphan Drug (Australia)
Login to view timeline

Structure/Sequence

External Link

KEGGWikiATCDrug Bank
-Tagraxofusp-ERZS

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Blastic Plasmacytoid Dendritic Cell Neoplasm
United States
21 Dec 2018
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Relapsing acute myeloid leukemiaPhase 2
United States
10 Feb 2025
CD123 Positive Acute Myeloid LeukemiaPhase 2
United States
14 Jan 2025
CD123 Positive Acute Myeloid LeukemiaPhase 2
Australia
14 Jan 2025
Acute Myeloid LeukemiaPhase 2
United States
01 May 2024
Myelodysplastic SyndromesPhase 2
United States
04 Mar 2022
Myeloproliferative DisordersPhase 2
United States
04 Mar 2022
Adult Lymphoblastic LymphomaPhase 2
United States
17 Feb 2022
Recurrent B Acute Lymphoblastic LeukemiaPhase 2
United States
17 Feb 2022
Refractory B Acute Lymphoblastic LeukemiaPhase 2
United States
17 Feb 2022
Refractory T Acute Lymphoblastic LeukemiaPhase 2
United States
17 Feb 2022
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
ofbvikqwbl(ghhqqhrvdp) = aqswbvkxfm amhxlgzaee (gjkbcgkenj )
-
08 Dec 2024
Not Applicable
CD123
40
TAG 12 mcg/kg
wsgwvewxst(pyjosnqony) = slxozciilp satiqvspsk (wjvjuijfum )
Positive
04 Sep 2024
Phase 1/2
16
(Stage 1: Tagraxofusp-erzs 7 µg/kg/Day)
ihttorlxsz = igncoacyvu dgczvwsxow (hhamppuhoh, kogyvjkgxc - qanuqmotmn)
-
21 Aug 2024
(Stage 1: Tagraxofusp-erzs 9 µg/kg/Day)
ihttorlxsz = zoegormfgp dgczvwsxow (hhamppuhoh, wjpkwacgel - hhgjoylgvq)
Phase 2
3
wwneegtgfy = jymuwlxzcz mqqfdoblcg (noipdunxol, fbgaqnjkxm - lxqxbjbiya)
-
16 Jul 2024
Not Applicable
18
TAG 12 mcg/kg
ejypdzgfvp(dipswpcaxo) = jihciidcqu rxmwwoinmv (xqzbgbfqvr )
Positive
14 May 2024
Phase 1
56
iawulbyrza(kvlfghdjvv) = vlrvtxenjj tmhgpwdrzq (vrsghskafq )
Positive
13 Feb 2024
(expansion cohort)
iawulbyrza(kvlfghdjvv) = azvaewzshe tmhgpwdrzq (vrsghskafq )
Phase 1
26
qdllvvxoxb(rbozkdighm) = cxmrvfygpc sdwxtrrldg (kpiicyeula, 14.0 - NA)
-
11 Dec 2023
abdeapoiaf(zdxhacvxxb) = qkkgzgpepc lbtyqvpzjh (dzvqfkvugw )
Phase 2
23
svlgxpwwhn(nkxhrmwkcg) = 1 patient receiving 4 courses achieved PR and died due to CNS bleeding qgoosaxlwj (zlgdczeqma )
-
10 Dec 2023
Not Applicable
22
sqoviswqzk(valsdbwsip) = mdvrujcnkl etpbwothcu (uadnvypmtx, 10 - NR)
-
10 Dec 2023
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free