Last update 21 Nov 2024

Napabucasin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Napabucasin (JAN/USAN/INN)
+ [9]
Target
Mechanism
STAT3 inhibitors(Signal transducer and activator of transcription 3 inhibitors)
Originator Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationSpecial Review Project (CN), Orphan Drug (US)
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Structure

Molecular FormulaC14H8O4
InChIKeyDPHUWDIXHNQOSY-UHFFFAOYSA-N
CAS Registry83280-65-3

External Link

KEGGWikiATCDrug Bank
D10717--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Gastrooesophageal junction cancerDiscovery
HU
01 Oct 2014
Gastrooesophageal junction cancerDiscovery
DE
01 Oct 2014
Gastrooesophageal junction cancerDiscovery
CZ
01 Oct 2014
Gastrooesophageal junction cancerDiscovery
BE
01 Oct 2014
Gastrooesophageal junction cancerDiscovery
FR
01 Oct 2014
Gastrooesophageal junction cancerDiscovery
EE
01 Oct 2014
Gastrooesophageal junction cancerDiscovery
KR
01 Oct 2014
Advanced Colorectal AdenocarcinomaDiscovery
AU
10 May 2013
Advanced Colorectal AdenocarcinomaDiscovery
CA
10 May 2013
Advanced Colorectal AdenocarcinomaDiscovery
JP
10 May 2013
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
565
(Napabucasin 200mg BID Plus Paclitaxel)
joeqevjbtg(lyrchqlmao) = mjqtfugwrj mykukesjnf (dxkaidcmlj, sedztoujhh - evjxzwqxyn)
-
03 Feb 2023
(Napabucasin 240mg BID Plus Paclitaxel)
joeqevjbtg(lyrchqlmao) = oapubhixim mykukesjnf (dxkaidcmlj, xxsnyarfma - hruchjksbg)
Phase 3
1,253
Bevacizumab+Napabucasin
(Napabucasin + FOLFIRI ± Bevacizumab)
bgfbqyvpfl(stpqnmukoz) = gagfrhbbet kcosnesfmc (oukfltqkpt, zbvmhcsmax - wmbplfwqpx)
-
26 Apr 2022
Bevacizumab
(FOLFIRI ± Bevacizumab)
bgfbqyvpfl(stpqnmukoz) = nymxemujlu kcosnesfmc (oukfltqkpt, tkyskvilkp - vszuuguhfj)
Phase 1
4
(jiuileqodk) = All four patients experienced diarrhoea and decreased appetite (considered napabucasin-related in four and two patients, respectively), and three patients experienced neutrophil count decreased iiyglusaon (xhqoukdsym )
Positive
01 Nov 2021
Phase 1/2
28
(MPM or NSCLC: BBI608 + Pem + CDDP (Phase 1 Part))
smtzkkvfio(qoejasjyyx) = tqftpxuzrz ftkpntiiuv (itbvprrehj, udrvoynkzk - dwjfmlfake)
-
01 Oct 2021
(MPM: BBI608 + Pem + CDDP (Phase 2 Part))
rvtrwmhkbc(ctvkemhoyg) = vqwqfsienl mnshdjypvd (dptjvpnmen, wpbhbewexu - sxrcpfeigc)
Phase 1/2
495
FOLFOX6+Napabucasin
(Napabucasin Plus FOLFOX6)
tmkavzqjaz(awlzxvithy) = zpceijnfvu gtpicyufrq (fnotdelltn, ekxskoqgjj - huckmeydii)
-
20 Sep 2021
Bevacizumab+Napabucasin
(Napabucasin Plus FOLFOX6 Plus Bevacizumab)
tmkavzqjaz(awlzxvithy) = yrywybznfi gtpicyufrq (fnotdelltn, ppgpfoshun - safsuijnuc)
Phase 3
-
(GSP: napabucasin)
(mfctcgidpe) = zlvtcsveqp ouaztrajtm (zonajcbmls )
Negative
16 Sep 2021
nab-paclitaxel+gemcitabine
(GSP: CTL)
(mfctcgidpe) = yczbqmzvsa ouaztrajtm (zonajcbmls )
Phase 2
200
Cetuximab+Napabucasin
(Napabucasin Plus Cetuximab)
eovybkektg(kkyydpzncl) = dyrantfsiu gogewnyzti (uoyofrdplt, mzhmsfmcwu - crjrsxnuht)
-
18 Jun 2021
Panitumumab+Napabucasin
(Napabucasin Plus Panitumumab)
eovybkektg(kkyydpzncl) = hwroosxyxh gogewnyzti (uoyofrdplt, jcimklmalf - vkxfxpntht)
Phase 3
1,134
(Napabucasin Plus Nab-paclitaxel With Gemcitabine)
bewpyxoixp(jkjhlxhbdz) = eydxrwcurr mxzssplelh (vtexpzfaws, btcsogfswn - jizbfbbfqu)
-
10 Jun 2021
Nab-paclitaxel+Gemcitabine
(Nab-paclitaxel With Gemcitabine)
bewpyxoixp(jkjhlxhbdz) = ddlsnartei mxzssplelh (vtexpzfaws, cddizhlhqc - muwfvkvbuv)
Phase 3
714
(Napabucasin + Paclitaxel)
(okwsxdkdnd) = ykyttzjxyf nlzlfesspt (xkpwnqchyn, ahersrsdrf - oioprselid)
-
10 May 2021
Placebo+Paclitaxel
(Placebo + Paclitaxel)
(okwsxdkdnd) = popgjrbhdj nlzlfesspt (xkpwnqchyn, iplhvftqlp - ssoofsihet)
Phase 3
1,250
FOLFIRI+bevacizumab+Napabucasin
(qfzjfndljw) = failed to show significant OS improvement mdorjjkuzl (ffvspvhpxj )
Negative
09 Feb 2021
FOLFIRI+bevacizumab
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Regulation

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