Delving into the Latest Updates on Napabucasin with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Napabucasin (JAN/USAN/INN), BB 608, BB-608

+ [9]

Target

STAT3

Mechanism

STAT3 inhibitors(Signal transducer and activator of transcription 3 inhibitors)

Therapeutic Areas

NeoplasmsDigestive System DisordersEndocrinology and Metabolic Disease

Active Indication

Pancreatic CancerMetastatic Pancreatic Ductal AdenocarcinomaMetastatic Colorectal Carcinoma+ [3]

Inactive Indication

Advanced cancerAdvanced Colorectal AdenocarcinomaAdvanced Gastroesophageal Junction Adenocarcinoma+ [12]

Originator Organization

Pharmaceutics International, Inc.

Active Organization

Pharmaceutics International, Inc.

Boston Biomedical, Inc.

1Globe Biomedical Co Ltd

+ [1]

Inactive Organization

Sumitomo Pharma America, Inc.

Sumitomo Pharma Co., Ltd.

Drug Highest PhasePhase 3

First Approval Date-

RegulationOrphan Drug (US)

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Structure

Molecular FormulaC14H8O4

InChIKeyDPHUWDIXHNQOSY-UHFFFAOYSA-N

CAS Registry83280-65-3

This is an open-label, multi-center, multi-national, non-randomized rollover study designed to allow continued access to napabucasin for patients who have participated in a Boston Biomedical-sponsored study and are being treated with napabucasin (monotherapy or combination) and who are deriving continued clinical benefit in the parent study at the time of closure.

Start Date24 Feb 2020

Sponsor / Collaborator

Sumitomo Pharma America, Inc.

NCT03721744 / RecruitingPhase 2/3

A Phase II/III Randomized, Open-Label Clinical Study of GB201 in Combination With Weekly Paclitaxel and Low-dose Gemcitabine in Patients With Metastatic Pancreatic Cancer Following Chemotherapy Failure

This is a Phase II/III Randomized, Open-Label Clinical Study of GB201 in Combination with Weekly Paclitaxel and Low-dose Gemcitabine in Patients With Metastatic Pancreatic Cancer Following Chemotherapy Failure

Start Date25 Oct 2018

Sponsor / Collaborator

1globe Health Institute LLC

CTR20180947 / RecruitingPhase 3

评价GB201联合紫杉醇和低剂量吉西他滨在一线治疗失败的转移性胰腺癌有效性和安全性的Ⅲ期临床研究

[Translation] Phase III clinical study to evaluate the efficacy and safety of GB201 combined with paclitaxel and low-dose gemcitabine in patients with metastatic pancreatic cancer who have failed first-line treatment

在一线治疗失败的转移性胰腺癌患者中对GB201联合紫杉醇和低剂量吉西他滨与标准治疗方案的总生存期（OS）的比较

[Translation]

Comparison of overall survival (OS) of GB201 combined with paclitaxel and low-dose gemcitabine versus standard of care in patients with metastatic pancreatic cancer who have failed first-line therapy

Start Date25 Oct 2018

Sponsor / Collaborator

1globe Health Institute LLC

[+2]

100 Clinical Results associated with Napabucasin

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100 Translational Medicine associated with Napabucasin

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100 Patents (Medical) associated with Napabucasin

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142

Literatures (Medical) associated with Napabucasin

01 Feb 2025·BIOMATERIALS

Napabucasin deactivates STAT3 and promotes mitoxantrone-mediated cGAS-STING activation for hepatocellular carcinoma chemo-immunotherapy

Article

Author: Yu, Shihan ; Li, Yutong ; Gao, Yuqiong ; Li, Zhuo ; Yang, Leilei ; Zou, Yifang ; Zhou, Xinyi ; Wang, Lingzhi ; Bi, Shengnan ; Shi, Jia ; Yu, Zhuo ; Liao, Anqi ; Zhang, Xuemei ; Guo, Jianfeng ; Liu, Xiaobo

12 Sep 2024·JOURNAL OF MEDICINAL CHEMISTRY

Natural Product-Inspired Discovery of Naphthoquinone-Furo-Piperidine Derivatives as Novel STAT3 Inhibitors for the Treatment of Triple-Negative Breast Cancer

Article

Author: Chen, Siyu ; Hu, Xueping ; Liao, Jialing ; Fan, Chengcheng ; Zhao, Huajun ; Ni, Hao ; Cui, Sunliang ; Lou, Shengying ; Shen, Chenjun ; Zhu, Zhihui ; Xie, Wei

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and STAT3 has emerged as an effective drug target for TNBC treatment. Herein, we employed a scaffold-hopping strategy of natural products to develop a series of naphthoquinone-furopiperidine derivatives as novel STAT3 inhibitors. The in vitro assay showed that compound 10g possessed higher antiproliferative activity than Cryptotanshinone and Napabucasin against TNBC cell lines, along with lower toxicity and potent antitumor activity in a TNBC xenograft model. Mechanistically, 10g could inhibit the phosphorylation of STAT3 and the binding affinity was determined by the SPR assay (K_D = 8.30 μM). Molecule docking studies suggested a plausible binding mode between 10g and the SH2 domain, in which the piperidine fragment and the terminal hydroxy group of 10g played an important role in demonstrating the success of this evolution strategy. These findings provide a natural product-inspired novel STAT3 inhibitor for TNBC treatment.

01 Sep 2024·BIOORGANIC CHEMISTRY

Design, synthesis and biological evaluation of novel naphthoquinothiazole derivatives as potent antitumor agents through inhibiting STAT3

Article

Author: Yang, Tao ; He, Xinlian ; Fan, Dongmei ; Liu, Pingxian ; Jiang, Weiqing ; Li, Zhilin ; Zhang, Lidan ; Ang, Wei

The signal transducer and activator of transcription 3 (STAT3) has been established as a crucial drug target in the development of antitumor agents. In this study, a series of 21 derivatives of the STAT3 inhibitor napabucasin were designed and synthesized. Through preliminary screening against tumor cell lines, SZ6 emerged as the most potent compound with half maximal inhibitory concentration (IC₅₀) values of 46.3 nM, 66.4 nM, and 53.8 nM against HCT116, HepG2, and Hela cells respectively. Furthermore, SZ6 effectively suppressed tumor invasion and migration in HCT116 cell assays by inducing S-phase arrest and apoptosis through inhibition of Protein Kinase B (PKB/AKT) activity and induction of reactive oxygen species (ROS). The mechanism underlying SZ6's action involves inhibition of STAT3 phosphorylation, which was confirmed by western blotting analysis. Additionally, surface plasmon resonance (SPR) and cellular thermal shift assay (CETSA) demonstrated direct binding between SZ6 and STAT3. Notably, in vivo studies revealed that SZ6 significantly inhibited tumor growth without any observed organ toxicity. Collectively, these findings identify SZ6 as a promising STAT3 inhibitor for colorectal cancer treatment.

1

News (Medical) associated with Napabucasin

21 Dec 2022

·www.prnewswire.com

Gastric Cancer Pipeline Space Brims With Novel Emerging Therapies with Over 200 Key Companies Working in the Domain | DelveInsight

The prevalence of gastric cancer has been rising since the past few years, which prompts the growing demand for treatment options. The increasing prevalence of cancer, the robust pipeline, and the growing research and development activities to develop novel therapies to treat Gastric Cancer drive the market. The companies developing the potential therapies in the last stage of development include Henlix Biotech, Eli Lilly and Company, Jiangsu Hengrui Medicine, and several others. LAS VEGAS, Dec. 21, 2022 /PRNewswire/ -- DelveInsight's ' Gastric Cancer Pipeline Insight – 2022 ' report provides comprehensive global coverage of available, marketed, and pipeline gastric cancer therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the gastric cancer pipeline domain. Key Takeaways from the Gastric Cancer Pipeline Report DelveInsight's gastric cancer pipeline report depicts a robust space with 200+ active players working to develop 230+ pipeline therapies for gastric cancer treatment. Key gastric cancer companies such as EMD Serono, Sumitomo Pharma, LintonPharm Co., Ltd., Rapa Therapeutics LLC, Jiangsu HengRui Medicine Co., Ltd., Janssen Pharmaceutical K.K., Genentech, Exelixis, Bristol-Myers Squibb, Pieris Pharmaceuticals, Inc., Pfizer, Leap Therapeutics, CSPC ZhongQi Pharmaceutical, Ellipses Pharma, Amgen, Hanmi Pharmaceutical, Taiho Oncology, Inc., Shanghai Henlius Biotech, LianBio LLC, Chengdu Kanghong Biotech,Eisai Inc., AB Science, Maxinovel Pharmaceuticals, Shanghai Miracogen Inc., GlaxoSmithKline, Hoffmann-La Roche, Merck Sharp & Dohme, Hutchison Medipharma Limited, Genome & Company, Minneamrita Therapeutics LLC, Suzhou Suncadia Biopharmaceuticals Co., Ltd., MacroGenics, ALX Oncology Inc., Codiak BioSciences, Turning Point Therapeutics, Inc., TCRx Therapeutics, InxMed (Shanghai) Co., Ltd., Imugene Limited, SOTIO Biotech, CARsgen Therapeutics Co., Ltd., Zymeworks Inc., NextCure, Inc., Phanes Therapeutics, Pieris Pharmaceuticals, Inc., Athenex, Inc., Curis, Inc., Qurient Co., Ltd., Acepodia Biotech, Inc., Sichuan Baili Pharmaceutical Co., Ltd., Tarus Therapeutics, Inc., Lumicell, Inc., Legend Biotech,Cue Biopharma, TORL Biotherapeutics, LLC, OBI Pharma, Inc, Astellas Pharma, HiberCell, Inc., Celon Pharma SA, Linnaeus Therapeutics, Inc., Inspirna, Inc., Klus Pharma Inc., Genzada Pharmaceuticals, Shanghai PerHum Therapeutics, VM Oncology, LLC, Immunomic Therapeutics, Peptron, and others are evaluating new gastric cancer drugs to improve the treatment landscape. Promising gastric cancer pipeline therapies in various stages of development include Avelumab, BBI608, Camrelizumab, Catumaxomab, RAPA-201, SHR-1210, Amivantamab, Atezolizumab, Bevacizumab, Cabozantinib, Cinrebafusp alfa, Crizotinib, DKN-01, DP303c, Eflornithine, EP0057, Epacadostat, FLX475, Futibatinib, GEN-001, HLX07, HLX22, Infigratinib, KH903, Lenvatinib, Masitinib, MAX-40279, MRG002, MRG003, Niraparib, Savolitinib, Minnelide, SHR-1701, Margetuximab, Bemarituzumab, Evorpacept, Lenvatinib, CDK-004, TPX-0022, TCRx_T Cells, IN10018, IMU-131, SOT102, CT041, AB011, Zanidatamab, NC410, PT 886, PRS-343, Oraxol, CA-4948, Q702, ACE1702, SI-B001, TT-4, LUM015, LB 1908, CUE-102, TORL-2-307-MAB, OBI-833/OBI-821, ASP2138, NC410, SO-C101, HC-5404-FU, CPL304110, LNS8801, RGX-202-01, A166, GZ17-6.02, HMPL-453, CCT303-406, VMD-928, ITI 4000, PAb 001, and others. In December 2022, Daiichi Sankyo and AstraZeneca's ENHERTU (trastuzumab deruxtecan) has been approved in the European Union (EU) as a monotherapy for the treatment of adult patients with advanced HER2 positive gastric or gastroesophageal junction (GEJ) adenocarcinoma who have received a prior trastuzumab-based regimen. In December 2022, RemeGen Co., Ltd. announced on December 7, 2022, that its latest antibody-drug conjugate (ADC), RC118 for injection, has been granted two orphan drug designations (ODD) by the United States Food and Drug Administration (FDA) for gastric cancer (including gastroesophageal junction cancer) and pancreatic cancer. This marks the Company's fourth, having previously been twice granted ODD for Disitamab Vedotin (RC48) and Telitacicept (RC18) earlier this year. In December 2022, Zhejiang Doer Biologics Co., Ltd. announced that it has entered into a clinical trial collaboration agreement with MSD (Merck & Co., Inc., Rahway, NJ, USA), to investigate Doer Bio's anti-Claudin18.2 antibody DR30303, in combination with MSD's anti-PD-1 therapy, KEYTRUDA® (pembrolizumab), in patients with Gastric or Gastroesophageal Junction Cancer. Under this agreement, Doer Bio will conduct a clinical study based on a mutually- agreed and finalized protocol to evaluate the safety and efficacy of DR30303 in combination with KEYTRUDA® in patients with Claudin18.2-positive, locally advanced unresectable or metastatic gastric or gastroesophageal junction (GC/GEJ) cancer. In November 2022, Triumvira Immunologics announced preclinical data for its investigational TAC-T cell therapies CLDN18.2-TAC T and GUCY2C-TAC T, and data on HER2-specific TAC-T products. Data was shared in three posters at the Society for Immunotherapy of Cancer (SITC) 37th Annual Meeting being held virtually and in-person in Boston.Triumvira announced updated data on its novel T cell antigen coupler (TAC)-T cell candidate targeting Claudin 18.2 (CLDN18.2) for the treatment of gastric cancer. The data continue to demonstrate that CLDN18.2-TAC T effectively eliminates CLDN18.2-expressing gastric cancer cells in vitro and in vivo. The study also demonstrated that the activation of CLDN18.2-TAC T cells was specific to target cells that expressed CLDN18.2. In vitro data show strong and persistent anti-tumor activity and in vivo treatment led to complete and sustained tumor clearance with no signs of toxicity. In September 2022, Nuvectis Pharma, Inc. announced positive data for NXP800 in a preclinical xenograft model of ARID1a-mutated gastric carcinoma.Mice in each group were treated with either vehicle or NXP800, and tumor volumes were measured over 28 days. Treatment with NX800 resulted in tumor regression and substantial tumor growth inhibition versus the control. In March 2022, Imugene (ASX: IMU) announced a new clinical trial collaboration and supply agreement with MSD, a tradename of Merck & Co., Inc., Kenilworth, NJ, USA, to evaluate the safety and efficacy of Imugene's HER-Vaxx, B-cell activating immunotherapy, in combination with MSD's anti-PD-1 therapy, pembrolizumab (KEYTRUDA®), in patients with HER-2 positive gastric cancer. Request a sample and discover the recent advances in gastric cancer drug treatment @ Gastric Cancer Pipeline Report The gastric cancer pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage gastric cancer drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the gastric cancer clinical trial landscape. Gastric Cancer Overview Stomach cancer is cancer that begins within the stomach or on the stomach wall. It is also known as gastric cancer. Stomach cancer is more common in the elderly. People aged 75 and above account for approximately 50 out of every 100 cases (around 50%). It affects men more than women. The exact gastric cancer causes are not known. Stomach cancer is linked to Helicobacter pylori, a bacteria that lives in the stomach. The most common gastric cancer symptoms are difficulty swallowing (dysphagia), weight loss, persistent indigestion (dyspepsia), feeling full after eating small amounts, feeling or being sick, and fatigue due to low red blood cell count (anaemia). Several tests, such as ultrasound, imaging tests, blood tests, and others, are used for gastric cancer diagnosis. Gastric cancer patients can receive a variety of treatments. Standard gastric cancer treatment consists of seven types: surgery, endoscopic mucosal resection, chemotherapy, radiation therapy, chemoradiation, targeted therapy, and immunotherapy. Find out more about chemotherapy drugs for gastric cancer @ New Gastric Cancer Drugs A snapshot of the Gastric Cancer Pipeline Drugs mentioned in the report: Learn more about the emerging gastric cancer pipeline therapies @ Gastric Cancer Clinical Trials Gastric Cancer Therapeutics Assessment The gastric cancer pipeline report proffers an integral view of gastric cancer emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration. Scope of the Gastric Cancer Pipeline Report Coverage: Global Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III Therapeutics Assessment By Route of Administration: Oral, Parenteral, Intravenous, Subcutaneous, Topical Therapeutics Assessment By Molecule Type: Monoclonal Antibody, Peptides, Polymer, Small molecule, Gene therapy Therapeutics Assessment By Mechanism of Action: Antibody-dependent cell cytotoxicity, Programmed cell death-1 receptor antagonists, T lymphocyte stimulants, Apoptosis stimulants, Macrophage stimulants, Natural killer cell stimulants, Cyclin-dependent kinase 4 inhibitors, Cyclin-dependent kinase 6 inhibitors, Antibody-dependent cell cytotoxicity, Angiogenesis inhibitors, Epidermal growth factor receptor antagonists, EIF 2 kinase inhibitors Key Gastric Cancer Companies: EMD Serono, Sumitomo Pharma, LintonPharm Co., Ltd., Rapa Therapeutics LLC, Jiangsu HengRui Medicine Co., Ltd., Janssen Pharmaceutical K.K., Genentech, Exelixis, Bristol-Myers Squibb, Pieris Pharmaceuticals, Inc., Pfizer, Leap Therapeutics, CSPC ZhongQi Pharmaceutical, Ellipses Pharma, Amgen, Hanmi Pharmaceutical, Taiho Oncology, Inc., Shanghai Henlius Biotech, LianBio LLC, Chengdu Kanghong Biotech,Eisai Inc., AB Science, Maxinovel Pharmaceuticals, Shanghai Miracogen Inc., GlaxoSmithKline, Hoffmann-La Roche, Merck Sharp & Dohme, Hutchison Medipharma Limited, Genome & Company, Minneamrita Therapeutics LLC, Suzhou Suncadia Biopharmaceuticals Co., Ltd., MacroGenics, ALX Oncology Inc., Codiak BioSciences, Turning Point Therapeutics, Inc., TCRx Therapeutics, InxMed (Shanghai) Co., Ltd., Imugene Limited, SOTIO Biotech, CARsgen Therapeutics Co., Ltd., Zymeworks Inc., NextCure, Inc., Phanes Therapeutics, Pieris Pharmaceuticals, Inc., Athenex, Inc., Curis, Inc., Qurient Co., Ltd., Acepodia Biotech, Inc., Sichuan Baili Pharmaceutical Co., Ltd., Tarus Therapeutics, Inc., Lumicell, Inc., Legend Biotech,Cue Biopharma, TORL Biotherapeutics, LLC, OBI Pharma, Inc, Astellas Pharma, HiberCell, Inc., Celon Pharma SA, Linnaeus Therapeutics, Inc., Inspirna, Inc., Klus Pharma Inc., Genzada Pharmaceuticals, Shanghai PerHum Therapeutics, VM Oncology, LLC, Immunomic Therapeutics, Peptron, and others. Key Gastric Cancer Pipeline Therapies: Avelumab, BBI608, Camrelizumab, Catumaxomab, RAPA-201, SHR-1210, Amivantamab, Atezolizumab, Bevacizumab, Cabozantinib, Cinrebafusp alfa, Crizotinib, DKN-01, DP303c, Eflornithine, EP0057, Epacadostat, FLX475, Futibatinib, GEN-001, HLX07, HLX22, Infigratinib, KH903, Lenvatinib, Masitinib, MAX-40279, MRG002, MRG003, Niraparib, Savolitinib, Minnelide, SHR-1701, Margetuximab, Bemarituzumab, Evorpacept, Lenvatinib, CDK-004, TPX-0022, TCRx_T Cells, IN10018, IMU-131, SOT102, CT041, AB011, Zanidatamab, NC410, PT 886, PRS-343, Oraxol, CA-4948, Q702, ACE1702, SI-B001, TT-4, LUM015, LB 1908, CUE-102, TORL-2-307-MAB, OBI-833/OBI-821, ASP2138, NC410, SO-C101, HC-5404-FU, CPL304110, LNS8801, RGX-202-01, A166, GZ17-6.02, HMPL-453, CCT303-406, VMD-928, ITI 4000, PAb 001, and others. Dive deep into rich insights for new drugs for gastric cancer treatment; visit @ Gastric Cancer Medications Table of Contents For further information on the gastric cancer pipeline therapeutics, reach out @ Gastric Cancer Drug Treatment Related Reports Gastric Cancer Epidemiology Forecast Gastric Cancer Epidemiology Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, and the gastric cancer epidemiology trends. Gastric Cancer Market Gastric Cancer Market Insight, Epidemiology, and Market Forecast – 2032 report delivers an in-depth understanding of the market trends, market drivers, market barriers, and key gastric cancer companies, including CSPC ZhongQi Pharmaceutical, Ellipses Pharma, Amgen, Hanmi Pharmaceutical, Taiho Oncology, Inc., Shanghai Henlius Biotech, among others. HER2+ Gastric Cancer Market HER2+ Gastric Cancer Market Insight, Epidemiology, and Market Forecast – 2032 report delivers an in-depth understanding of the market trends, market drivers, market barriers, and key HER2+ gastric cancer companies, including Pieris Pharmaceuticals, BioInvent International, Bellicum Pharmaceuticals, Mersana Therapeutics, Acepodia Biotech, Inc., Klus Pharma Inc, among others. HER2+ Gastric Cancer Pipeline HER2+ Gastric Cancer Pipeline Insight – 2022 report provides comprehensive insights about the pipeline landscape, including clinical and non-clinical stage products, and the key HER2+ gastric cancer companies, including Pieris Pharmaceuticals, BioInvent International, Bellicum Pharmaceuticals, Mersana Therapeutics, Acepodia Biotech, Inc., Klus Pharma Inc, among others. HER2+ Gastric Cancer Epidemiology HER2+ Gastric Cancer Epidemiology Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, and the HER2+ gastric cancer epidemiology trends. Other Trending Oncology Reports Follicular lymphoma | Indolent lymphoma | Severe Toxicities In Lymphoma | Marginal Zone Lymphoma | Vulvar Squamous Cell Carcinoma | Cholangiocarcinoma | Metastatic Cutaneous Squamous cell Carcinoma | Nasopharyngeal Carcinoma | Ductal Carcinoma in Situ | Oncolytic Virus Cancer Therapy | Cancer Cachexia | Intratumoral Cancer Therapies | Brain Cancer Related Cases Studies Competitive Intelligence Market Assessment Product Assessment Epidemiology Assessment Related Healthcare Services Healthcare Business Consulting Healthcare Competitive Intelligence Services Healthcare Asset Prioritization Services About DelveInsight DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. Connect with us at LinkedIn Contact Us Shruti Thakur [email protected] +1(919)321-6187 Logo: SOURCE DelveInsight Business Research, LLP

ImmunotherapyOrphan DrugDrug Approval

100 Deals associated with Napabucasin

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KEGG	Wiki	ATC	Drug Bank
D10717	-	-	DB12155

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Pancreatic Cancer	Phase 3	CN	1globe Health Institute LLC	25 Oct 2018
Secondary malignant neoplasm of pancreas	Phase 3	CN	1globe Health Institute LLC	25 Oct 2018
Secondary malignant neoplasm of pancreas	Phase 3	FR	1globe Health Institute LLC	25 Oct 2018
Secondary malignant neoplasm of pancreas	Phase 3	ES	1globe Health Institute LLC	25 Oct 2018
Metastatic Pancreatic Ductal Adenocarcinoma	Phase 3	US	Pharmaceutics International, Inc.	10 Feb 2017
Metastatic Pancreatic Ductal Adenocarcinoma	Phase 3	US	1Globe Biomedical Co Ltd	10 Feb 2017
Metastatic Pancreatic Ductal Adenocarcinoma	Phase 3	US	Boston Biomedical, Inc.	10 Feb 2017
Metastatic Pancreatic Ductal Adenocarcinoma	Phase 3	JP	Pharmaceutics International, Inc.	10 Feb 2017
Metastatic Pancreatic Ductal Adenocarcinoma	Phase 3	JP	Boston Biomedical, Inc.	10 Feb 2017
Metastatic Pancreatic Ductal Adenocarcinoma	Phase 3	JP	1Globe Biomedical Co Ltd	10 Feb 2017

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02358395 (Pubmed)	Phase 1	Unresectable Hepatocellular Carcinoma	6	Napabucasin (480 mg/day) plus Sorafenib (800 mg/day)	wbpmtazqyd(zzqwpqjihi) = stable disease yhknqcthxk (zzbfxejdjy )	-	15 May 2023
NCT01325441 (CTgov)	Phase 1/2	Neoplasms	565	Paclitaxel+Napabucasin (Napabucasin 200mg BID Plus Paclitaxel)	nmwppndllh(cvkiftxewm) = mzpquzmbtv mrrjpvypiy (ozvqxhxetf, jsjhgnldct - mjxdhyssaf) View more	-	03 Feb 2023
				Paclitaxel+Napabucasin (Napabucasin 240mg BID Plus Paclitaxel)	nmwppndllh(cvkiftxewm) = tsksatyyog mrrjpvypiy (ozvqxhxetf, tqtbvzbtde - hqkqwbkwmq) View more
NCT02753127 (CanStem303C, CTgov)	Phase 3	Metastatic Colorectal Carcinoma	1,253	Bevacizumab+Napabucasin (Napabucasin + FOLFIRI ± Bevacizumab)	wfijzzfcdw(ccexuxqfhz) = cwekcuivgr xgionphzvo (makiqupgtf, trtdcggzlj - wjfietuacq) View more	-	26 Apr 2022
				Bevacizumab (FOLFIRI ± Bevacizumab)	wfijzzfcdw(ccexuxqfhz) = uqwkgxnawc xgionphzvo (makiqupgtf, caeveuxygm - cjlztsxdlq) View more
NCT02641873 (Pubmed \| Int J Clin Oncol) Manual	Phase 1	Metastatic Colorectal Carcinoma	4	bevacizumab+fluorouracil+leucovorin+irinotecan+napabucasin	shndincdsn(fedtvtvvsw) = All four patients experienced diarrhoea and decreased appetite (considered napabucasin-related in four and two patients, respectively), and three patients experienced neutrophil count decreased sonpqwtepy (hrjqzvzaku )	Positive	01 Nov 2021
NCT02347917 (CTgov)	Phase 1/2	Malignant Pleural Mesothelioma \| Non-Small Cell Lung Cancer	28	Pem+CDDP+BBI608 (MPM or NSCLC: BBI608 + Pem + CDDP (Phase 1 Part))	zffiuwxuzj(bsccisyiar) = hrprwhiamr qrwronmgll (mmjknrcxbo, vaviydmgxn - chesstwtqj) View more	-	01 Oct 2021
				Pem+CDDP+BBI608 (MPM: BBI608 + Pem + CDDP (Phase 2 Part))	taiaegriiy(pzudtwyygs) = enqulkmonn tsqysqrfoj (pwyyzzrxyv, brhofwince - tbtiwyaxmm) View more
NCT02024607 (CTgov)	Phase 1/2	Gastrointestinal Neoplasms	495	FOLFOX6+Napabucasin (Napabucasin Plus FOLFOX6)	panmketqvb(alithvoybb) = bwsdkewfef gvmhffeugp (nhcctgtndo, bwevgmmkej - ghrehisqbr) View more	-	20 Sep 2021
				Bevacizumab+Napabucasin (Napabucasin Plus FOLFOX6 Plus Bevacizumab)	panmketqvb(alithvoybb) = kzwyiloeie gvmhffeugp (nhcctgtndo, nlqxbhpnbr - snilceuabu) View more
NCT02993731 (CanStem111P, ESMO2021) Manual	Phase 3	Pancreatic adenocarcinoma metastatic First line	-	nab-paclitaxel+gemcitabine+napabucasin (GSP: napabucasin)	rrkkvjjslf(radjvljymh) = uknshfojic fofobuwpfg (ukbdnpihro ) View more	Negative	16 Sep 2021
				nab-paclitaxel+gemcitabine (GSP: CTL)	rrkkvjjslf(radjvljymh) = efmcmzmwvk fofobuwpfg (ukbdnpihro ) View more
NCT02753127 (CanStem303C, ESMO_GI2021)	Phase 3	Metastatic Colorectal Carcinoma pSTAT3+	1,253	FOLFIRI + napabucasin 240 mg oral, twice daily	diuysnesdl(vcwaiukzgk) = rdpqcziyfu gtassqregz (nrhxmwgjcz )	Negative	03 Jul 2021
				FOLFIRI	diuysnesdl(vcwaiukzgk) = uqhyjsrdhe gtassqregz (nrhxmwgjcz )
NCT01776307 (BBI608-224, CTgov)	Phase 2	Advanced Colorectal Adenocarcinoma	200	Cetuximab+Napabucasin (Napabucasin Plus Cetuximab)	orrqdtamqr(rioaonnzxg) = axxfmgledx aadoaqtnaq (bounmljpwr, mxiahgwnel - qglvofoasx) View more	-	18 Jun 2021
				Panitumumab+Napabucasin (Napabucasin Plus Panitumumab)	orrqdtamqr(rioaonnzxg) = sppaaaqgzv aadoaqtnaq (bounmljpwr, lwcjpxzrho - uebvmwxmsr) View more
NCT02993731 (CanStem111P, CTgov)	Phase 3	Pancreatic adenocarcinoma metastatic \| Pancreatic Ductal Carcinoma	1,134	Nab-paclitaxel+Gemcitabine+Napabucasin (Napabucasin Plus Nab-paclitaxel With Gemcitabine)	ncdwgceict(ohmjwnqcff) = hevpshoucx fcpxlblzey (slubcuyrns, sanhpsivqq - hirtajsxcm) View more	-	10 Jun 2021
				Nab-paclitaxel+Gemcitabine (Nab-paclitaxel With Gemcitabine)	ncdwgceict(ohmjwnqcff) = xnjhyreqca fcpxlblzey (slubcuyrns, guhgtflzdc - otedrmuqhn) View more