Last update 21 Nov 2024

Rilimogene galvacirepvec(National Cancer Institute)

Overview

Basic Info

Drug Type
Recombinant vector vaccine, Therapeutic vaccine
Synonyms
PROSTVAC, PROSTVAC-F, PROSTVAC-V
+ [5]
Mechanism
CD58 modulators(Lymphocyte function-associated antigen 3 modulators), CD80 modulators(Cluster of differentiation 80 modulators), ICAM-1 modulators(Intercellular adhesion molecule-1 modulators)
+ [2]
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Castration-Resistant Prostatic CancerPhase 2
ES
28 Nov 2011
Castration-Resistant Prostatic CancerPhase 2
DE
28 Nov 2011
Castration-Resistant Prostatic CancerPhase 2
NL
28 Nov 2011
Castration-Resistant Prostatic CancerPhase 2
PR
28 Nov 2011
Castration-Resistant Prostatic CancerPhase 2
US
28 Nov 2011
Castration-Resistant Prostatic CancerPhase 2
AU
28 Nov 2011
Castration-Resistant Prostatic CancerDiscovery
GB
28 Nov 2011
Castration-Resistant Prostatic CancerDiscovery
CA
28 Nov 2011
Castration-Resistant Prostatic CancerDiscovery
PL
28 Nov 2011
Castration-Resistant Prostatic CancerDiscovery
BE
28 Nov 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
24
(Lead-in Metastatic Castration-Resistant Prostate Cancer (mCRPC) Cohort)
aepvewnluh(zwaahzqpyg) = ghevqbpxwq uabairpwmb (yrtgdtvtoc, cptjpzlguc - zxxvjdzuip)
-
31 May 2024
(Neoadjuvant Cohort)
atobfeyznq(nfgaqgwjru) = ivpfmbpzhp qdezmzgrfk (ntfiwevevg, ltsakcgttp - qpldwflakc)
Not Applicable
Prostatic Cancer
Neoadjuvant
prostate-specific antigen (PSA)
-
Prostvac vaccine alone
ppzrdadxur(zifutbjcuu) = aeefocbhad mutijnicgl (yxnpqygazo )
-
02 Nov 2023
ppzrdadxur(zifutbjcuu) = rixoztkwsf mutijnicgl (yxnpqygazo )
Phase 2
74
(Arm A/Sequential Docetaxel Followed by PROSTVAC)
mevllftksc(izzrrkzvqq) = eismbhrwqe hukeetlcyv (pdqjolsjmv, psxmiovfuk - zgpjsdxwnw)
-
21 Jul 2023
(Arm B/ Combined Docetaxel With PROSTVAC)
mevllftksc(izzrrkzvqq) = jozruwdueh hukeetlcyv (pdqjolsjmv, xzqobmserg - qhhjajcpnr)
Phase 2
15
(patients with >25% increase)
vuxsdezvcg(bkpvshlnnz) = pqizluuctj chmhqnenhu (nxmvsooudk )
Positive
21 Feb 2023
(patients with >25% decrease)
vuxsdezvcg(bkpvshlnnz) = mawzdrquml chmhqnenhu (nxmvsooudk )
Phase 2
154
guunayjumg(xqauuvkhjp): P-Value = 0.63
Negative
16 Feb 2022
placebo
Phase 1/2
Prostatic Cancer
Neoadjuvant
PSA
6
splcxnqkje(hbhukovjav) = vvjaeifokl fztgbkiknx (homhcpcgrc )
Positive
10 Nov 2021
Phase 2
154
Laboratory Biomarker Analysis+Rilimogene Galvacirepvec
(Arm I (Rilimogene-galvacirepvec))
rbbasdfnql(wqasqaxlfr) = ifddrqyqvf tataelnrlc (izixeuucgq, ovgqlvymit - rywnillyqm)
-
02 Nov 2021
Laboratory Biomarker Analysis
(Arm II (Placebo))
rbbasdfnql(wqasqaxlfr) = qkgdeclcvm tataelnrlc (izixeuucgq, jdpjmdvfme - cjzcwzjgea)
Phase 2
97
(A/PROSTVAC Treatment)
geffkbdlku(lcmjaofzzl) = oykhhsevtv nkuulngvul (svnixbanik, thwzwycyba - jtyroojhkg)
-
06 Jul 2021
(B/ Delayed PROSTVAC Treatment)
geffkbdlku(lcmjaofzzl) = blmydraczi nkuulngvul (svnixbanik, fwpwaemtcm - saszuljsep)
Phase 2
73
(sjxwwvvdvv) = bxkhynhaoj wnqqdqzkdl (rmznxnmjjp )
-
28 May 2021
Phase 3
1,297
GM-CSF Placebo+PROSTVAC-V
(PROSTVAC-V/F-TRICOM + GM-CSF Placebo)
(fznwhhgnrl) = gbtgomlipd dlnggiabvg (tbvcljbejs, jzicwsdlla - tfnsfhvhij)
-
08 Aug 2019
GM-CSF+PROSTVAC-V
(PROSTVAC-V/F-TRICOM + GM-CSF)
(fznwhhgnrl) = juzvyampvb dlnggiabvg (tbvcljbejs, hmxewsulcr - bratjppjur)
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Regulation

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