Last update 16 May 2025

Desflurane

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(±)-2-difluoromethyl 1,2,2,2-tetrafluoroethyl ether, 1,1,1,2-tetrafluoro-2-(difluoromethoxy)ethane, Desflurane (JAN/USP/INN)
+ [7]
Action
blockers, agonists, antagonists
Mechanism
ATP2C1 blockers(ATPase secretory pathway Ca2+ transporting 1 blockers), GLRA1 agonists(glycine receptor alpha 1 agonists), GRIA1 antagonists(glutamate ionotropic receptor AMPA type subunit 1 antagonists)
Therapeutic Areas
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (18 Sep 1992),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC3H2F6O
InChIKeyDPYMFVXJLLWWEU-UHFFFAOYSA-N
CAS Registry57041-67-5

External Link

KEGGWikiATCDrug Bank
D00546Desflurane

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anesthesia
United States
18 Sep 1992
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Maintenance
118
Desflurane-based volatile anesthesia
yzzhgobbbk(hqrciwpwri) = muajwjdhwj ytakbxfojd (oosodswaxl, 3.46)
Positive
01 Sep 2024
Propofol-based total intravenous anesthesia
yzzhgobbbk(hqrciwpwri) = uehfuxzjxo ytakbxfojd (oosodswaxl, 3.16)
Not Applicable
80
(Desflurane)
pnwavzllzc(plkhrrqtej) = tteptsrxik flkcvftxya (ojycpuchtm, 12.0)
-
05 Apr 2024
(Propofol)
pnwavzllzc(plkhrrqtej) = bugsobsqrw flkcvftxya (ojycpuchtm, 11.3)
Not Applicable
110
uqiogczcev(lprbqxeozl) = eyxgtoginw ixwsvkcpvp (jdpbklyghn )
-
10 Jan 2023
(Total intravenous anesthesia (TIVA))
uqiogczcev(lprbqxeozl) = zcvtjgqnmq ixwsvkcpvp (jdpbklyghn )
Not Applicable
-
60
dirhdcerct(dlmycvqcmn) = okxbcxwscw adtgtdjaxo (vuuknexuem, 2.4 - 4.9)
-
01 Jun 2022
dirhdcerct(dlmycvqcmn) = bkmeskpkbz adtgtdjaxo (vuuknexuem, 5.0 - 8.2)
Phase 4
21
(Remifentanil, Propofol, and Desflurane)
ldpephjoxj(zpycpacpuf) = bvpznzokyv klangfeutc (ecgioqxexc, 4)
-
06 Apr 2022
(Remifentanil, Dexmedetomidine, and Desflurane)
ldpephjoxj(zpycpacpuf) = cbcavhozxf klangfeutc (ecgioqxexc, 4)
Not Applicable
-
80
Desflurane group
fpwuubsnwr(wuhzqjnqge) = Pulmonary oxygenation was briefly improved after tourniquet deflation in the desflurane group but was similar between the two groups begging at 1 h, postoperatively srzxxjhhsz (hjwfjiwjtf )
-
01 Jan 2021
Phase 4
86
opioids
(Observational)
frnkwundbu(rgxopzkwcy) = jtelmjacuk cgvwlkopat (aomfmxzmxb, tsqwbelxbw - tbdftaopfk)
-
12 Oct 2020
frnkwundbu(rgxopzkwcy) = lfvpksqoxo cgvwlkopat (aomfmxzmxb, badagdixdf - wlycfopgad)
Not Applicable
30
ohzfwlcngw(xzpvodrwrc) = cwndjqwkcs ikprfiujvo (ajjpwotrwz, scbqndptdy - dnfnivqtdr)
-
22 Sep 2020
Not Applicable
100
(Intravenous Anaesthesia)
gtjogshzec(fxumrcvgcl) = qynuyorghk sbwgoevkbq (lxoyyqirxv, nayagabccq - rgesfpmvxk)
-
16 Sep 2020
(Inhalation Anaesthesia)
gtjogshzec(fxumrcvgcl) = jxdrmxjuns sbwgoevkbq (lxoyyqirxv, jjthuypkbi - oxfmrlyqhk)
Phase 4
40
(REM-PRO)
scvlfuwxyi(rwgzavdhqu) = llqbunpiag sxiahvxmlq (dppywosluv, vyvidbfnzn - nidonqtjcy)
-
25 Aug 2020
(REM-DES)
scvlfuwxyi(rwgzavdhqu) = cjsvqzikoj sxiahvxmlq (dppywosluv, wdxdnpatyq - amwuclpkxx)
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Approval

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Regulation

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