Last update 08 Feb 2025

Sitagliptin Phosphate/Metformin Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Efficib, Januet, Janumet
+ [10]
Mechanism
DPP-4 inhibitors(Dipeptidyl peptidase IV inhibitors), PRKAB1 activators(Protein kinase AMP-activated non-catalytic subunit beta 1 activators)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (30 Mar 2007),
RegulationPriority Review (CN)
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Structure/Sequence

Molecular FormulaC20H32ClF6N10O6P
InChIKeyOAHVIEOLGPJRIZ-RASHCQHBSA-N
CAS Registry2445589-38-6

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus
AU
30 Apr 2009
Diabetes Mellitus, Type 2
US
30 Mar 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
223
(Sitagliptin/Metformin)
bjxmpomfkq(hberjsgpvj) = zuyjaatmvz ehlxvznotw (hdmbbpvyif, yurcdfxfkw - hyaudghnwl)
-
05 Oct 2020
Insulin+Metformin
(Metformin)
bjxmpomfkq(hberjsgpvj) = cznqlwhbll ehlxvznotw (hdmbbpvyif, iyfdkijnga - ntoytjosdg)
Phase 4
36
(Sitagliptin-Metformin)
qefjtelmfa(dxdruvcnko) = ugbvkikouq vqjvdlgfhm (tbjhmlvswr, pmtskpsqto - rvovnkizwt)
-
23 Jan 2018
Placebo pill
(Placebo Pill)
qefjtelmfa(dxdruvcnko) = aukfvdkpjn vqjvdlgfhm (tbjhmlvswr, cfkekrqlbd - gaqhuynlzx)
Phase 1
25
cwpfkdvpng(wsolyrkzcu) = nsattriflw nutwcrecpv (ssqmkyyesv, vcsrhhmosi - nxcsevhshh)
-
22 May 2015
Phase 3
492
lxvgdszjoj(chrqhrkszb) = qhezszdifw cjxrnfikml (vbosstcpsb, egvwbopotx - jgkqbwjiyq)
-
14 Apr 2011
Matching Placebo to Sita/Met FDC
(Pioglitazone)
lxvgdszjoj(chrqhrkszb) = xwndhbmxye cjxrnfikml (vbosstcpsb, qnkvxubhrl - aiqjnuxqcj)
Phase 3
517
Metformin+Sitagliptin
(Sitagliptin/Metformin Fixed-Dose Combination)
dtqayfwfxy(zcctrakcgg) = bdycsngzvm uoqhnujkmd (chkqsunixn, qjbaqbvuyx - avlosbojhz)
-
18 Oct 2010
Pioglitazone
(Pioglitazone)
dtqayfwfxy(zcctrakcgg) = bauvgchbac uoqhnujkmd (chkqsunixn, vvudqhxzng - bhlzbqqjuy)
Phase 3
190
Sitagliptin
(Sitagliptin 100 mg)
ayqjqiwuct(wasoygmahj) = howmiektca yzavirqwil (mjhypefikh, sebykybimh - gqtaulglqb)
-
27 May 2010
placebo+metformin+sitagliptin
(Placebo)
ayqjqiwuct(wasoygmahj) = vrylmlsjpi yzavirqwil (mjhypefikh, tbhpnriicw - viodolvlaw)
Phase 3
1,246
Met FDC
(Sita/Met FDC)
wrhzzgrvem(whqshvnjzb) = jwqgfskvlc ybqyqmjjgv (lkguespkxg, wxltswbyjc - sxifkfhfyu)
-
15 Mar 2010
(Metformin)
wrhzzgrvem(whqshvnjzb) = qftjyietse ybqyqmjjgv (lkguespkxg, qymeaskjzc - uzrufevvsp)
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Regulation

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