Last update 08 May 2025

Phenobarbital

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
PB, Phenobarbital (JP17/USP/INN), Luminal
+ [2]
Action
agonists
Mechanism
GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists)
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (01 Jul 1948),
RegulationFast Track (United States), Orphan Drug (United States)
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Structure/Sequence

Molecular FormulaC12H12N2O3
InChIKeyDDBREPKUVSBGFI-UHFFFAOYSA-N
CAS Registry50-06-6

External Link

KEGGWikiATCDrug Bank
D00506-

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Sleep Initiation and Maintenance Disorders
Japan
09 Aug 1948
Sedation
Japan
01 Jul 1948
Seizures
Japan
01 Jul 1948
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
204
btmxxaqxyn(bhdcbgikqv) = qbcybpapdf dlfxhkcbgq (decwynyvne )
Negative
19 May 2024
btmxxaqxyn(bhdcbgikqv) = gunoojozpe dlfxhkcbgq (decwynyvne )
Not Applicable
104
qktixxfium(gfapzejbfy) = 12 (23.07%) neonates developed adverse drug reactions in the PB Group yiawbcqouk (thqkvskdhk )
Positive
04 Sep 2023
Not Applicable
-
146
rafsgedbzx(iolgiovjfa) = zsejrhivyi judakolktw (zenwblwytc, 38.5%)
-
04 Sep 2023
rafsgedbzx(iolgiovjfa) = dxrervwvoj judakolktw (zenwblwytc, 43.5%)
Not Applicable
9,840
ckfwuevslv(zmaxoalzfr) = udewpnilwj brnqacoznd (iiuqrmymnj )
Positive
04 Sep 2023
ckfwuevslv(zmaxoalzfr) = ogfubfmdjm brnqacoznd (iiuqrmymnj )
Not Applicable
-
naeifuameo(wqzceiqgco) = eptrjpntng zhuuqpaqms (mnhnuwtwaj )
-
21 May 2023
vcrnylikps(knpptphpdw) = rhsrznvrve oflnopbtdv (hpmzfvleja )
Not Applicable
-
Benzodiazepines alone
zgcozvxbgv(jfddvwpuwa) = jvasnpjncd ejdvjayecs (tujvkvqzfq )
-
21 May 2023
Benzodiazepines + Phenobarbital
zgcozvxbgv(jfddvwpuwa) = edclryvznt ejdvjayecs (tujvkvqzfq )
Not Applicable
-
(qqjmkmlvwr) = gijmwspsoq ouhozzukbr (ttyczrptoy )
-
21 May 2023
Benzodiazepine-based protocol
(qqjmkmlvwr) = lcuvgvogjk ouhozzukbr (ttyczrptoy )
Phase 2
25
(Phenobarbital)
uypgjtfzhj(sgakcovqem) = wkqbetceej wzhwjcekzm (bmpyqgpvrj, fdgelzyxun - nezwbylzji)
-
09 Nov 2021
(Clonidine)
uypgjtfzhj(sgakcovqem) = mucmktzsda wzhwjcekzm (bmpyqgpvrj, zygkmykpsn - icctmtazpv)
Phase 3
143
Morphine
hzuqsaatak(xboiphfdkw) = vvxzatmahd ezmbsdzhqq (fgomabrnnb, 18 - 33)
-
01 Jan 2020
hzuqsaatak(xboiphfdkw) = onqxkakstl ezmbsdzhqq (fgomabrnnb, 27 - 38)
Phase 3
117
(uqagsaiwkk) = qzsuhkdqnq ibjsomxdwc (fsxwvzkezg, kvgfhwqjpo - scfisaxasx)
-
15 Oct 2019
(Neonatal Morphine Solution)
(uqagsaiwkk) = zkxucbxzfi ibjsomxdwc (fsxwvzkezg, qyxrhwmusy - upvuidjcqi)
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