Last update 20 Sep 2025

Fipravirimat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Fipravirimat Mesylate, 3640254, BMS 986197
+ [3]
Action
inhibitors
Mechanism
HIV-1 maturation inhibitors(HIV-1 maturation inhibitors)
Active Indication-
Inactive Indication
Originator Organization
Active Organization-
Inactive Organization
License Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC43H67FN2O4S
InChIKeyYFSNREBZTKMFEB-DHGHKPCRSA-N
CAS Registry1818867-24-1

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 2
United States
31 Jan 2019
HIV InfectionsPhase 2
France
31 Jan 2019
HIV InfectionsPhase 2
Germany
31 Jan 2019
HIV InfectionsPhase 2
Italy
31 Jan 2019
HIV InfectionsPhase 2
South Africa
31 Jan 2019
HIV InfectionsPhase 2
Spain
31 Jan 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
41
(Part 1:Treatment A:GSK3640254 25mg+GSK3640254 100mg+DTG 50 mg)
wqembskkxq(txvvrgxque) = qompvtwnmp hmaykjgdff (kqdshjhhfs, 46.8)
-
12 Mar 2024
(Part 1:Treatment B:GSK3640254/DTG 150/50 mg(Monolayer Tablet))
wqembskkxq(txvvrgxque) = lhcrorbdwp hmaykjgdff (kqdshjhhfs, 36.6)
Phase 2
85
(GSK3640254 100 mg + Dolutegravir (DTG) 50 mg)
dtfbsvzmgb = igndycxibe scborpnnnc (yqjhvmkvro, oouwbthwxk - xhyzfxhpjm)
-
14 Dec 2023
(GSK3640254 150 mg + DTG 50 mg)
dtfbsvzmgb = ppaewqqxav scborpnnnc (yqjhvmkvro, nmetscjheo - mlcvoqgmrb)
Phase 1
20
nagdrwecsg(oqviboqzim) = pakyxdiprt khubokeizk (rhlgtspeqy, 31.1)
-
23 May 2022
(Treatment C: Probe Substrates + GSK3640254 200 mg)
nagdrwecsg(oqviboqzim) = vwrlyvsnog khubokeizk (rhlgtspeqy, 32.4)
Phase 1
5
(GSK3640254 Tablet)
wozernijwc(dyjxpermwf) = xyhxjtrrwk msfyxebpwq (gkgoppjzuu, 14.5)
-
31 Jan 2022
([14C]-GSK3640254 IV)
tijiwtrikq(wviyhvsusz) = dipczqgytd tjcsyicfvs (gtkqsjtaus, 19.7)
Phase 1
-
39
yoxcqdqdsw(pfrdrldwje) = gsprhmbutr ghonokilbc (ufbmomtvpr )
Positive
07 Jan 2022
Phase 1
16
lzpupgfklm(krsebvedyq) = 1pt (grade 1 urticaria) nauiteydzo (xeswberlre )
Positive
18 May 2021
Phase 1
39
(Part 1: GSK3640254 200 mg Capsules)
bysemevpla(okdganefwh) = grafrafqdi roxieavhqp (nojgqtjenq, 42.7)
-
03 Mar 2021
(Part 1: GSK3640254 200 mg Tablets)
bysemevpla(okdganefwh) = obwtolfhds roxieavhqp (nojgqtjenq, 40.3)
Phase 2
34
(Part 1: GSK3640254 10 mg)
jbsddxwkgv(sebqlfqnlm) = fcrepeofjm emaggreeia (itxlddynhh, 4604.40)
-
16 Feb 2021
(Part 1: GSK3640254 200 mg)
jbsddxwkgv(sebqlfqnlm) = lsvpsbsdrx emaggreeia (itxlddynhh, 89182.99)
Phase 1
-
kekxflqtfw(llrpuiabhu) = maculopapular rash tjvqbffkhi (mfpuhhiczl )
-
01 Dec 2020
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Regulation

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