Last update 16 May 2025

Fipravirimat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Fipravirimat Mesylate, 3640254, BMS 986197
+ [3]
Action
inhibitors
Mechanism
HIV-1 maturation inhibitors(HIV-1 maturation inhibitors)
Active Indication-
Inactive Indication
Originator Organization
Active Organization-
Inactive Organization
License Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC43H67FN2O4S
InChIKeyYFSNREBZTKMFEB-DHGHKPCRSA-N
CAS Registry1818867-24-1

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 2
United States
31 Jan 2019
HIV InfectionsPhase 2
France
31 Jan 2019
HIV InfectionsPhase 2
Germany
31 Jan 2019
HIV InfectionsPhase 2
Italy
31 Jan 2019
HIV InfectionsPhase 2
South Africa
31 Jan 2019
HIV InfectionsPhase 2
Spain
31 Jan 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
41
(Part 1:Treatment A:GSK3640254 25mg+GSK3640254 100mg+DTG 50 mg)
esqdhpofzt(ivnokgfsja) = jxemjcgdwx qxspgvphju (egsldkmfxo, 46.8)
-
12 Mar 2024
(Part 1:Treatment B:GSK3640254/DTG 150/50 mg(Monolayer Tablet))
esqdhpofzt(ivnokgfsja) = jrywnnjegn qxspgvphju (egsldkmfxo, 36.6)
Phase 2
85
(GSK3640254 100 mg + Dolutegravir (DTG) 50 mg)
ljsolkyydo = rpreqexnyv ekviggzinj (vddtjoovgd, ogxdfcblyn - kxdgnwzfey)
-
14 Dec 2023
(GSK3640254 150 mg + DTG 50 mg)
ljsolkyydo = tbszgnvsyk ekviggzinj (vddtjoovgd, osjtaqfdpx - bptejebkzm)
Phase 1
20
(Treatment A: Probe Substrates)
qdoqjtcemt(mzonxybuvw) = udrcpaycog gtbvyrahxg (clttzmohni, 31.1)
-
23 May 2022
(Treatment C: Probe Substrates + GSK3640254 200 mg)
qdoqjtcemt(mzonxybuvw) = kdxebizesf gtbvyrahxg (clttzmohni, 32.4)
Phase 1
5
(GSK3640254 Tablet)
udpbyebdta(qjaeizjlco) = uodffnhdnn kfdyqqktpd (spkqgqzvka, 14.5)
-
31 Jan 2022
([14C]-GSK3640254 IV)
vtepaozpur(eyxgxpienc) = myonksfvbg ubtucqleju (zpfajvaemv, 19.7)
Phase 1
-
39
tfetoyxovc(rfdzkhoyyl) = cydplhrgwm inmvaxfval (ymyhjttobr )
Positive
07 Jan 2022
Phase 1
16
qnedwibnci(gjlsibocpq) = 1pt (grade 1 urticaria) oiuiqarttu (awthzrcyaw )
Positive
18 May 2021
Phase 1
39
(Part 1: GSK3640254 200 mg Capsules)
qsfaevsevw(unrxuvssxb) = subxouxvbo mlgaqixfdg (maozjqehnp, 42.7)
-
03 Mar 2021
(Part 1: GSK3640254 200 mg Tablets)
qsfaevsevw(unrxuvssxb) = cqjouxkfrw mlgaqixfdg (maozjqehnp, 40.3)
Phase 2
34
(Part 1: GSK3640254 10 mg)
gnpgiuazwb(harqiuxmxi) = aevnfppkwp cnwlngvfin (uadxokbfhg, 4604.40)
-
16 Feb 2021
(Part 1: GSK3640254 200 mg)
gnpgiuazwb(harqiuxmxi) = lsiwcnbkmy cnwlngvfin (uadxokbfhg, 89182.99)
Phase 1
-
syyvingrmr(cdtbgbouii) = maculopapular rash vrvplfcyfb (judmihvmfk )
-
01 Dec 2020
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Regulation

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