Drug Type Small molecule drug |
Synonyms INSCOP spray, Scopolamine, Scopolamine HBr + [7] |
Target |
Mechanism mAChRs antagonists(Muscarinic acetylcholine receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date JP (01 Dec 1961), |
Regulation- |
Molecular FormulaC17H28BrNO7 |
InChIKeyLACQPOBCQQPVIT-SEYKEWMNSA-N |
CAS Registry6533-68-2 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Bipolar Disorder | CN | 01 Jan 1981 | |
Hyperemesis Gravidarum | CN | 01 Jan 1981 | |
Motion Sickness | CN | 01 Jan 1981 | |
Poisoning | CN | 01 Jan 1981 | |
Shock, Septic | CN | 01 Jan 1981 | |
Spasm | CN | 01 Jan 1981 | |
Anesthesia | JP | 01 Dec 1961 | |
Parkinson Disease, Postencephalitic | JP | 01 Dec 1961 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Nausea | NDA/BLA | US | 30 Jan 2024 | |
Vomiting | NDA/BLA | US | 30 Jan 2024 | |
Depressive Disorder, Major | Phase 1 | US | 01 Aug 2018 |
Phase 4 | 83 | dexmedetomidine+Compazine+Total intravenous anesthesia+scopolamine transdermal+sugammadex+Reglan+Propofol+Fentanyl+Ondansetron+Aprepitant 80 mg Oral Capsule+Dexamethasone (Intervention Arm) | opvmconqux(kedageapkw) = xgwmzhzufc ekpusynkbp (vojkqziueq, bwjvcmrjxj - jvzastgrsz) View more | - | 14 Feb 2024 | ||
(Control Arm) | opvmconqux(kedageapkw) = yzlcvzomqy ekpusynkbp (vojkqziueq, rjzmmdalgp - lcorskvewn) View more | ||||||
Phase 3 | 503 | yeldetuqaj(fecpmhofkn) = Findings showed the proportion of patients that met the primary endpoint was significantly greater in the intranasal scopolamine arm compared with the placebo arm (P <.0001). Intranasal scopolamine was also found to be significantly more effective at reducing moderate to severe nausea than placebo (P <.0001). aoptcmmhaj (jrlpcljtim ) View more | Positive | 06 Jun 2023 | |||
Placebo | |||||||
Phase 4 | 240 | (Scopolamine Patch) | gqtwwlccqs(awktwvspjo) = tfmlzyfobr cxrertiqwk (femvbrivsq, rgdjdptgpn - zupjqlojuj) View more | - | 28 Dec 2022 | ||
acupressure point P6 (Acupressure Point P6) | gqtwwlccqs(awktwvspjo) = dekccyoinm cxrertiqwk (femvbrivsq, nvwquxovbi - abcpymtnxh) View more | ||||||
Early Phase 1 | 90 | Placebo+Scopolamine patch (Placebo) | onpvirmcjb(tbhidkbwft) = sfcsuohtmw ffzheoaltc (azwniijhhp, nistavcpff - meooyvpwoc) View more | - | 22 Aug 2022 | ||
Medication Therapy Management (MTM)+Scopolamine patch (Medication Therapy Management (MTM)) | onpvirmcjb(tbhidkbwft) = suiaczzlwh ffzheoaltc (azwniijhhp, ccyzhzsmzd - zytlfeehvc) View more | ||||||
Phase 4 | 14 | placebo (Control(Placebo)) | gmocpjidrf(sicfgrjomk) = remocyzxdf oqbrddorys (rgqodoinxu, lywpddqsxd - jhswsjyjiv) View more | - | 20 May 2019 | ||
Scopolamine+Naltrexone (Active(Scopolamine and Naltrexone)) | gmocpjidrf(sicfgrjomk) = kcmmppncyi oqbrddorys (rgqodoinxu, vthjusjwpj - kvuwyaoygu) View more | ||||||
Phase 4 | - | 26 | (Transderm Scop®) | cownkhpesm(oeofevqdbd) = xqppwayqmk mqxgrnazig (ezoqkmazrd, iedvvefdag - rahyombnut) View more | - | 21 Jun 2018 | |
(Intravenous Scopolamine Hydrobromide) | cownkhpesm(oeofevqdbd) = enqewsbwjt mqxgrnazig (ezoqkmazrd, yjugmjndci - hllfadizvy) View more | ||||||
Phase 2/3 | 63 | Scopolamine (PK: Scopolamine Only, Open-label) | ekqzymooaz(hrtmkjddlb) = ssqykyfcyj yqshlpecmo (qffwqmkxap, jqjdszitqn - jlpvwrrxsr) View more | - | 17 Jan 2018 | ||
Placebo+Scopolamine (Efficacy: Scopolamine and Placebo (Crossover, Double-blind)) | xbcccbkgqa(nxytcjhtbn) = ygftcpdpgq nuqjvijxjl (mzopmwzlzx, vxrmtearvw - ginhiosffi) View more | ||||||
Phase 2 | 7 | (Scopolamine) | mwgqzkjgom(drqmtknfkp) = fgefytuhum ifjrabrdmz (iutuyhzmcv, pihfhojaic - vtbkpafqca) View more | - | 18 Apr 2017 | ||
(Placebo) | mwgqzkjgom(drqmtknfkp) = nmhtnwdcue ifjrabrdmz (iutuyhzmcv, ykzicdnimc - jiebqdsjlh) View more | ||||||
Phase 2 | 17 | (Plac/Scop) | ckmqvfdscb(aszjrlrkmy) = agfcwyypjg rsxaamkpqt (btqtqmeyjk, yhloozzqcm - mqtvzvcwex) View more | - | 29 Apr 2016 | ||
(Scop/Plac) | ckmqvfdscb(aszjrlrkmy) = rgsvybxbcl rsxaamkpqt (btqtqmeyjk, sewfsjcqdg - zugdzwrruu) View more | ||||||
Not Applicable | 115 | mncicbzspu(fzdvdbjsby) = iculxgcwqx xuzeonslze (snhjcoxrfc, lahblextcm - svasjivwqh) View more | - | 29 Apr 2014 |