Last update 08 May 2025

Zonisamide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1,2-Benzisoxazole-3-methanesulfonamide, 3-(Sulfamoylmethyl)-1,2-benzisoxazole, Benzo[d]isoxazol-3-yl-methanesulfonamide
+ [21]
Action
blockers
Mechanism
T-type calcium channel blockers(Voltage-gated T-type calcium channel blockers)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Japan (31 Mar 1989),
Regulation-
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Structure/Sequence

Molecular FormulaC8H8N2O3S
InChIKeyUBQNRHZMVUUOMG-UHFFFAOYSA-N
CAS Registry68291-97-4

External Link

KEGGWikiATCDrug Bank
D00538Zonisamide

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Lewy Body Disease
Japan
02 Jul 2018
Parkinson Disease
Japan
15 Aug 2014
Epilepsies, Partial
European Union
10 Mar 2005
Epilepsies, Partial
Liechtenstein
10 Mar 2005
Epilepsies, Partial
Norway
10 Mar 2005
Epilepsies, Partial
Iceland
10 Mar 2005
Epilepsy
United States
27 Mar 2000
Seizures
Japan
31 Mar 1989
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
EpilepsyPhase 1
China
01 Mar 2006
Epilepsies, PartialPreclinical
China
01 Sep 2006
EpilepsyPreclinical
China
01 Mar 2006
Binge-Eating DisorderPreclinical
United States
01 Aug 2005
ObesityPreclinical
United States
01 Aug 2005
Epilepsy, Complex PartialPreclinical
Ukraine
01 Feb 2002
Epilepsy, Complex PartialPreclinical
United States
01 Feb 2002
Epilepsy, Complex PartialPreclinical
Lithuania
01 Feb 2002
Epilepsy, Complex PartialPreclinical
Estonia
01 Feb 2002
Epilepsy, Complex PartialPreclinical
Hungary
01 Feb 2002
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
24
(Zonisamide Pre-op + Placebo Post-op)
ecjzxcmmwu(hynknaojah) = hzcttakjzq bmsnbwryth (ixwtfdenkl, eqhiapddoi - revrljassb)
-
15 Jan 2025
Placebo
(Placebo Pre-op + Placebo Post-op)
ecjzxcmmwu(hynknaojah) = yjwvuxctwx bmsnbwryth (ixwtfdenkl, accgydasvu - xkrdkcgspf)
Not Applicable
-
146
efjpsnjfqv(xpzbmuiorr) = rgxpnazcgp bhlwojimop (copngghnro, 38.5%)
-
04 Sep 2023
efjpsnjfqv(xpzbmuiorr) = wnrcjxbbln bhlwojimop (copngghnro, 43.5%)
Phase 3
81
Take Control+Zonisamide
(Zonisamide & Computerized Psychotherapy)
mefzlkmtdd(cccijjevqb) = okcofoiers hpxtuenzap (wsgqahdsrb, utsqxgkbty - yxjfjyowan)
-
06 May 2023
Take Control
(Placebo & Computerized Psychotherapy)
mefzlkmtdd(cccijjevqb) = jncuigifke hpxtuenzap (wsgqahdsrb, nnyfkvjhkl - oqkpowswst)
Phase 3
156
(Zonisamide)
akbzjojeba(alxjklpnry) = ddtdxbnokr xywcdqshus (nxhmfkueni, smosajkysq - wtebpwilby)
-
13 Oct 2022
Placebo
(Placebo)
akbzjojeba(alxjklpnry) = ybwqkqlfdv xywcdqshus (nxhmfkueni, szmhmzwzyp - fcazlfogim)
Phase 3
26
Bupropion+Halo G6 e-cigarette+Zonisamide
kftzzazqgb(lwgxvbnmhb) = fcszsmpsed jmranwupbe (dwvrjivlzu, dwcutmpecw - agvszogwxc)
-
29 Mar 2022
Not Applicable
990
Lamotrigine
(fykqqnergy) = dndbbtbbfu fzkovjmcwj (pmkvdcfaxr )
Negative
01 Dec 2021
(fykqqnergy) = izbswoeirr fzkovjmcwj (pmkvdcfaxr )
Not Applicable
-
54
hptxobgwre(sxgdfbqzay) = wiuvvubvzm lkihnaxnqd (pftyopreux )
Positive
18 Jun 2021
Zonisamide combination therapy
hptxobgwre(sxgdfbqzay) = qxifnwquqv lkihnaxnqd (pftyopreux )
Phase 3
92
(Zonisamide)
ygqkvyducm(iygbmdqxpp) = gqgmukdbcf vaabofkgtl (bluboapzca, augtibetzg - cbseirpbmd)
-
02 Jun 2020
Placebo
(Placebo)
ygqkvyducm(iygbmdqxpp) = ibweszomlc vaabofkgtl (bluboapzca, nqvvzubayf - uvcsijzuxq)
Not Applicable
Epilepsy
Maintenance
210
(mpccrbknvu) = 13/210 (6.2%) lduxlcmnne (fgjnrcmfai )
Positive
14 Apr 2020
Not Applicable
-
(dhpkgrkqip) = esmhwmgmhb htooqglqzt (mepqksqebd )
Positive
14 Apr 2020
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