This article summarized the latest R&D progress of Clofibrate, the Mechanism of Action for Clofibrate, and the drug target R&D trends for Clofibrate.

AbbVie, Inc. is a pharmaceutical organization that was founded in 2013 and is based in Illinois, United States.

PCSK9 is a serine protease synthesized by the liver, which can bind to and degrade the low-density lipoprotein receptor (LDL-R), reducing LDL-R's clearance of low-density lipoprotein cholesterol (LDL-C) in the serum.

Sugemalimab is an anti-PD-L1 monoclonal antibody developed by CStone Pharmaceuticals.

Recently, BridgeBio Pharma announced that its investigational treatment, acaracides, achieved its primary endpoint in the phase 3 clinical trial.

On August 29, 2023, Novartis released new long-term data from its ORION-8 Phase 3 clinical trial. The data showed that its twice-yearly RNAi therapy, Leqvio (Inclisiran, Sodium Echociliran), in combination with statins.

On August 29, 2023, AbbVie submitted a new indication application to the US FDA and European EMA for Skyrizi (Risankizumab) for the treatment of moderate to severe ulcerative colitis (UC) in adults.

Merck announced that Merck announced that the European Commission has approved KEYTRUDA, Merck’s anti-PD-1 therapy, in combination with trastuzumab, fluoropyrimidine- and platinum-containing chemotherapy, for the first-line treatment of locally advanced unresectable or metastatic human epidermal growth factor receptor 2 (HER2)-positive gastric or gastroesophageal junction adenocarcinoma in adults whose tumors express PD-L1 (Combined Positive Score≥1).

The Center for Drug Evaluation, NMPA (CDE) shows that the application for the listing of Overland Pharmaceutical's CD19 antibody-drug conjugate (ADC), Loncastuximab, has been accepted. This is also the first China-reported ADC targeting CD19. CD19 is a popular target in the development of antitumor drugs. If Loncastuximab is approved, multiple types of drugs, including monoclonal antibodies, bispecific antibodies, CAR-T cells, and ADCs, will fulfill this target. We take Loncastuximab as an example to retrieve its related biological sequences.

AEON Biopharma, Inc. has shared encouraging results from their recent Phase 2 medical trial of ABP-450.

TScan Therapeutics, Inc.announced today that the U.S. FDA has given approval for its new experimental drug TSC-203-A0201, a TCR-T pinpointing PReferentially expressed Antigen in Melanoma.

SparingVision has shared encouraging early safety data from the Phase I/II clinical trial of its primary gene-agnostic gene therapy, SPVN06, designed to treat retinitis pigmentosa.