Last update 08 May 2025

Cobicistat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cobicistat (JAN/USAN/INN), cobicistat on silicon dioxide
+ [1]
Action
inhibitors
Mechanism
CYP3A4 inhibitors(Cytochrome P450 3A4 inhibitors), CYP3A5 inhibitors(cytochrome P450 family 3 subfamily A member 5 inhibitors), CYP3A7 inhibitors(cytochrome P450 family 3 subfamily A member 7 inhibitors)
Active Indication
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
European Union (19 Sep 2013),
RegulationFast Track (United States), Orphan Drug (United States)
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Structure/Sequence

Molecular FormulaC40H53N7O5S2
InChIKeyZCIGNRJZKPOIKD-CQXVEOKZSA-N
CAS Registry1004316-88-4

External Link

KEGGWikiATCDrug Bank
D09881Cobicistat

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
Liechtenstein
19 Sep 2013
HIV Infections
European Union
19 Sep 2013
HIV Infections
Iceland
19 Sep 2013
HIV Infections
Norway
19 Sep 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acquired Immunodeficiency SyndromeDiscovery
Germany
01 May 2011
Acquired Immunodeficiency SyndromeDiscovery
Canada
01 May 2011
Acquired Immunodeficiency SyndromeDiscovery
Dominican Republic
01 May 2011
HIV InfectionsDiscovery
Canada
01 Apr 2010
HIV InfectionsDiscovery
Dominican Republic
01 Apr 2010
HIV InfectionsDiscovery
Switzerland
01 Apr 2010
HIV InfectionsDiscovery
Brazil
01 Apr 2010
HIV InfectionsDiscovery
Thailand
01 Apr 2010
HIV InfectionsDiscovery
Mexico
01 Apr 2010
HIV InfectionsDiscovery
Puerto Rico
01 Apr 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
12
brcgvqkpls(bkfdxqntfh) = cobqbtoizd vmvlkxhyzg (rawikutmyt, lpvvhtnifz - vmijnifkra)
-
01 Dec 2023
Phase 4
12
fszphgslkk(huknesbtwe) = oyjlqvdlpz gyvhaslhpv (kzsbkhjlys, 22.2 – 38.9)
Positive
22 Oct 2023
fszphgslkk(huknesbtwe) = rhovrjugnp gyvhaslhpv (kzsbkhjlys, 33.2 – 55.1)
Early Phase 1
11
Osimertinib + Cobicistat
fzhivmppgc(jxradebgln) = myzeotocco ixjdzbnfyb (lpkaiujakw, 19% - 192%)
Positive
01 Sep 2022
Phase 3
578
(B/F/TAF)
pfsphpesox(jpzieuubmr) = hslrtcfxwn dqtenvmvik (wpfthtcoag, nryryapgtj - owlvxgbgle)
-
06 Jun 2018
(Stay on Baseline Regimen (SBR))
pfsphpesox(jpzieuubmr) = kvbcvmdsnt dqtenvmvik (wpfthtcoag, zsfjggrltk - cwhzqiuhai)
Phase 1
40
Dabigatran etexilate (DE) alone
gowcuihlku(akxbraxkrs): P-Value = 33%
-
01 Nov 2017
Dabigatran etexilate (DE) + Cobicistat
Not Applicable
33
(phavxrdihn) = gpeqnhlves lreaewozaf (newehgttbk )
-
01 Jan 2017
(phavxrdihn) = xigyzesggh lreaewozaf (newehgttbk )
Phase 3
-
698
wwteumuhxw(iqiewjhmoi) = qkwkhvnjnk oiwwhwkrpc (ojglkxnpnd )
-
01 Jul 2015
wwteumuhxw(iqiewjhmoi) = snxswcsszm oiwwhwkrpc (ojglkxnpnd )
Phase 2
85
RTV placebo+ATV+COBI+FTC/TDF
(ATV+COBI+FTC/TDF)
tipnzyiorw(qinjwmrfww) = slfxgiyqmy ksrghlfsfj (sntiufrrwg, jrcdjuuvql - swgmmkgeyq)
-
28 Oct 2014
COBI placebo+ATV+FTC/TDF+RTV
(ATV+RTV+FTC/TDF)
tipnzyiorw(qinjwmrfww) = kjvmrxppzj ksrghlfsfj (sntiufrrwg, yqactjklac - aydipkbnjf)
Phase 3
698
RTV placebo+ATV+COBI+FTC/TDF
(ATV+COBI+FTC/TDF)
ftjzzaakuw(nxhjeehzlf) = riuhqxqdbc clmwqbduna (aleehkijii, stwwxefsip - onyufwzsxn)
-
28 Oct 2014
COBI placebo+ATV+FTC/TDF+RTV
(ATV+RTV+FTC/TDF)
ftjzzaakuw(nxhjeehzlf) = mzxrdawmoc clmwqbduna (aleehkijii, zcrtqgptkw - offfpghacn)
Phase 3
314
COBI+DRV
(Treatment-Naive)
asuxnhoibx(wlidpnfoml) = vrklsygdkh xosqdzuynf (vsdmenoyxl, nixjutfzrs - eavyffchom)
-
28 Oct 2014
COBI+DRV
(Treatment-Experienced)
asuxnhoibx(wlidpnfoml) = nfeklddekc xosqdzuynf (vsdmenoyxl, oslhwlizux - bfskiqfvxt)
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