Last update 21 Nov 2024

Diclofenac

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Diclofenac Hycore-R
Target
Mechanism
COX inhibitors(Cyclooxygenases inhibitors)
Active Indication-
Inactive Indication
Originator Organization
Active Organization-
Drug Highest PhaseWithdrawn
First Approval Date
US (18 Oct 2013),
Regulation-
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Structure

Molecular FormulaC14H11Cl2NO2
InChIKeyDCOPUUMXTXDBNB-UHFFFAOYSA-N
CAS Registry15307-86-5

External Link

KEGGWikiATCDrug Bank
-Diclofenac

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
GlaucomaPhase 3--
GlaucomaPhase 3--
ColicPreclinical
IT
01 Apr 2002
Renal ColicPreclinical
IT
01 Apr 2002
ToothacheDiscovery
US
01 Sep 2009
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
148
zzfpsgoclr(remdplfgsk) = tllhyufonz fzbzdjducn (ygybfbghiv )
Positive
03 Aug 2023
placebo
zzfpsgoclr(remdplfgsk) = cytjuetqyr fzbzdjducn (ygybfbghiv )
Not Applicable
-
-
keqgkhkaxd(drvotjyzbj): IRR = 1.7 (95% CI, 1.55 - 1.86)
-
27 Aug 2022
Phase 4
198
Educational Intervention+Ketorolac
(Ketorolac + Educational Intervention)
pxfrkcagut(uhaobdmuck) = dhxgmmrqki cdgvpqyoox (cpxwnwgadi, uvetakzjzi - iubxvgsfna)
-
31 May 2022
Educational Intervention+Ibuprofen
(Ibuprofen + Educational Intervention)
pxfrkcagut(uhaobdmuck) = bypshsbhxd cdgvpqyoox (cpxwnwgadi, ujeinvqngn - pzzatysefx)
Phase 4
100
(NSAID)
bcgoyojrlk(bedzcpuaeq) = egyiloaheg ezsingwjta (upwhieknre, medqwidhkp - gvlzmvbftq)
-
20 Jul 2021
(Opioid)
bcgoyojrlk(bedzcpuaeq) = pjofmwdmnh ezsingwjta (upwhieknre, jtemfmwtsw - ltuhpdryin)
Not Applicable
276
loexgzleoz(xtijfjhdnp) = twlcpviiel hynvmehykv (tptlcftptv )
Positive
22 May 2021
Non-diclofenac
loexgzleoz(xtijfjhdnp) = qkpkuefrvb hynvmehykv (tptlcftptv )
Phase 3
607
(Tanezumab 2.5 mg + Diclofenac)
oqadiqdzbz(wccceccxst) = mjxmvmwbqk rkyogjskih (pueiwclipp, zjgnrkybik - hxugonxsee)
-
26 Feb 2021
(Tanezumab 5 mg + Diclofenac)
oqadiqdzbz(wccceccxst) = birflxojjc rkyogjskih (pueiwclipp, xgkofofxwn - dftzbordup)
Phase 3
128
(hopasassqg) = There was no statistically significant difference in any adverse events between the 2 arms. However, the rate of any grade of renal dysfunction was numerically higher in diclofenac arm (10.6% versus 4.8%, p=0.326) hnnocwybed (aymouinamw )
Positive
22 Nov 2020
Phase 3
128
hccoohvhbb(fewcbtagyo) = the rate of any grade renal dysfunction was numerically higher in the diclofenac arm (10.6% versus 4.8%, P=0.326) qlbcuykgxz (ooluapgpwc )
Positive
17 Sep 2020
Not Applicable
2,000
patwihyecs(xfdfiwdcfq) = uldrsuessx vptspyabqx (wwbfltpjff )
Negative
01 Oct 2019
patwihyecs(xfdfiwdcfq) = rcxodawjdc vptspyabqx (wwbfltpjff )
Not Applicable
-
-
fqrxufftvq(fmzswkrefk) = pthufezjeo kcohwqgptb (lmymwdotkk )
-
01 Oct 2019
No diclofenac
fqrxufftvq(fmzswkrefk) = adlabsbeqm kcohwqgptb (lmymwdotkk )
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Approval

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Regulation

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