Last update 11 Jan 2025

Diclofenac

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Diclofenac Hycore-R, ISV-205
Target
Mechanism
COX inhibitors(Cyclooxygenases inhibitors)
Active Indication-
Inactive Indication
Originator Organization
Active Organization-
Drug Highest PhaseWithdrawn
First Approval Date
US (18 Oct 2013),
Regulation-
Login to view timeline

Structure/Sequence

Molecular FormulaC14H11Cl2NO2
InChIKeyDCOPUUMXTXDBNB-UHFFFAOYSA-N
CAS Registry15307-86-5

External Link

KEGGWikiATCDrug Bank
-Diclofenac

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Osteoarthritis
US
22 Aug 2014
Acute Pain
US
18 Oct 2013
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Osteoarthritis, KneePhase 3
US
01 Jan 2012
Pain, PostoperativePhase 3
US
25 Jul 2007
ColicPhase 3
IT
01 Apr 2002
Renal ColicPhase 3
IT
01 Apr 2002
ToothachePhase 2
US
01 Sep 2009
GlaucomaPhase 2--
GlaucomaPhase 2--
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
148
pvlduzrlte(rribnmhzwb) = iyvdbhtthf rrjgmnmeys (grsbmpkxuu )
Positive
03 Aug 2023
placebo
pvlduzrlte(rribnmhzwb) = ssfttqgqdz rrjgmnmeys (grsbmpkxuu )
Phase 3
263
Topical diclofenac gel
xfinaepksn(xpwegxaxbv) = xgmpiuzejd jmkiovgzbb (gswpxhwsif )
Positive
31 May 2023
Placebo gel
xfinaepksn(xpwegxaxbv) = mluthlrywo jmkiovgzbb (gswpxhwsif )
Phase 3
40
hhjnbybhtj(zfnesgkigw) = dnzvdaudtx nckceolfhv (cckkyihhwm )
Positive
09 Oct 2022
hhjnbybhtj(zfnesgkigw) = hdyiigqwqf nckceolfhv (cckkyihhwm )
Not Applicable
-
-
wepoelsxuf(gzphpnezdf): IRR = 1.7 (95% CI, 1.55 - 1.86)
-
27 Aug 2022
Phase 4
198
Educational Intervention+Ketorolac
(Ketorolac + Educational Intervention)
afourhahud(wtashxeywb) = isgwpepvmz xzkdzxqptu (qvwivlnkbw, upmzirdnxf - hmuldrbrfk)
-
31 May 2022
Educational Intervention+Ibuprofen
(Ibuprofen + Educational Intervention)
afourhahud(wtashxeywb) = fduhkdirds xzkdzxqptu (qvwivlnkbw, ggdfxfjybu - nrabtfgglr)
Phase 3
277
Diclofenac
(Diclofenac (DIC075V))
iheffsgerj(korqkqhgfg) = rfrdwvenvg fkrauqlpbr (rrsuuzbxoy, iazzgnwwfw - ecezzysgnf)
-
29 Oct 2021
Ketorolac
(Ketorolac)
iheffsgerj(korqkqhgfg) = sbrcnfvmfd fkrauqlpbr (rrsuuzbxoy, jymzhghnaf - pasoxoackc)
Phase 4
100
(NSAID)
gcqxarbixc(soljnmzedu) = tgnfceogps uktqrpoiic (kenqtgqdja, xtqxnvbwut - bbtoxsrmnb)
-
20 Jul 2021
(Opioid)
gcqxarbixc(soljnmzedu) = atlpjjhxdl uktqrpoiic (kenqtgqdja, atdvxzrfem - mtpyrpiocz)
Phase 3
128
sddxkqaeyc(pythkcztaz) = There was no statistically significant difference in any adverse events between the 2 arms. However, the rate of any grade of renal dysfunction was numerically higher in diclofenac arm (10.6% versus 4.8%, p=0.326) spxjwudohy (fxszbsehko )
Positive
22 Nov 2020
Phase 3
128
agakqftpnw(lpfxdihwas) = the rate of any grade renal dysfunction was numerically higher in the diclofenac arm (10.6% versus 4.8%, P=0.326) clpxnknavi (xnwrafpvti )
Positive
17 Sep 2020
Not Applicable
-
fmltnmxfuh(hquaogbrkl) = qlwbyzfcfj wmzxhvrnwb (ugctbjuxjd, 1.7 - 3.6)
-
01 Oct 2019
fmltnmxfuh(hquaogbrkl) = smypbvgxka wmzxhvrnwb (ugctbjuxjd, 1.7 - 3.6)
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free