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Last update 19 Jul 2025
Dexrazoxane Hydrochloride
Last update 19 Jul 2025
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms dexrazoxane, Topotect, Totect + [13] |
Target |
Action inhibitors |
Mechanism Top II inhibitors(Topoisomerase II inhibitors) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (26 May 1995), |
RegulationAccelerated Approval (United States), Orphan Drug (United States), Orphan Drug (Australia) |
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Structure/Sequence
Molecular FormulaC11H17ClN4O4 |
InChIKeyBIFMNMPSIYHKDN-FJXQXJEOSA-N |
CAS Registry149003-01-0 |
Related
55
Clinical Trials associated with Dexrazoxane HydrochlorideChiCTR2500101472
Early Application of Edaravone Dexrazoxane In The Treatment of Acute Non-Large Vessel Occlusive Ischemic Stroke
NCT06647953
Prospective Treatment of Types I, II and III Pleuropulmonary Blastoma (PPB)
NCT06220032
ANTICIPATE: Prevention of ANThracycline-Induced Cardiac Dysfunction by Dexrazoxane In PATients With diffusE Large B-cell Lymphoma: a Phase III National Multicenter Prospective Randomized Open-label Trial
100 Clinical Results associated with Dexrazoxane Hydrochloride
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100 Translational Medicine associated with Dexrazoxane Hydrochloride
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100 Patents (Medical) associated with Dexrazoxane Hydrochloride
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1,230
Literatures (Medical) associated with Dexrazoxane Hydrochloride01 Dec 2025Natural Products and Bioprospecting
Design, synthesis and biological evaluation of buthutin derivatives as cardioprotective agents
Article
Author: Liu, Yu-Ming ; Wang, Li-Ning ; Gou, Xiang-Bo ; Yang, Shu-Han ; Hua, Xin-Hao ; Wang, Fa-Qi ; Xu, Yun-Sheng ; Liu, Yuan ; Shao, Chen-Yue
Abstract:
Natural products are the important sources in cardiovascular drug development. In this study, twenty-nine buthutin derivatives were designed, synthesized, and evaluated for their NHE-1 inhibition and protective effects on cardiomyocyte injury. The structure of the newly synthesized compounds had been confirmed by 1H-NMR, 13C-NMR, and HR-ESI-MS spectra. Among all target compounds at 1 μM, compounds 9d, 9f, 9k, 9m, and 9n, with a protection ratio exceeding 30%, exerted stronger protective effects on H9c2 cardiomyocyte than positive control dexrazoxane and buthutin A. Meanwhile, compounds 9k, 9m, and 9o showed the significant NHE-1 inhibitory activities on H9c2 cardiomyocyte, all with a dpHi/min value less than 0.23. What is more, compounds 9k, 9m, 9o and buthutin A all exhibited the specificity on NHE-1 inhibition. Molecular modelling studies suggested the ability of compounds 9m and 9o to establish interactions with three hydrogen bonds to Asp267 and Glu346 of NHE-1, but also the ability with much lower CDOCKER energies than positive control cariporide and buthutin A. The structure–activity relationship (SAR) studies suggested that the presences of amide group, four-carbon linker, and para hydroxyl benzene ring were advantageous pharmacophores for above two pharmacological actions. This research would open new avenues for developing amide-guanidine-based cardioprotective agents.Graphical Abstract
01 Oct 2025BIOCHEMICAL PHARMACOLOGY
Herbacetin mitigates oxidative stress and ferroptosis to protect against doxorubicin-induced cardiotoxicity
Article
Author: Xin, Wenxu ; Sun, Ning ; Yang, Hai ; Huang, Shaohong ; Zhang, Ke ; Ye, Chao ; Heng, Xinyu
The chemotherapy agent doxorubicin (DOX) is significantly constrained in its clinical application due to its notable cardiotoxicity. Dexrazoxane is the only drug approved by the FDA for the prevention of DOX-induced carditoxicity; however, it may also diminish the sensitivity of cancer cells to DOX chemotherapy. Consequently, there is an urgent need for the development of safe and effective therapeutic agents to mitigate the cardiotoxic effects induced by DOX. In this study, C57BL/6J mice and H9C2 cardiomyocytes were employed to establish models of DOX-induced cardiotoxicity. We examined the effects of herbacetin on myocardial damage, cardiac function, oxidative stress, ferroptosis and the associated signaling pathways using a variety of experimental techniques. Our results demonstrated that herbacetin mitigated DOX-induced myocardial damage and cardiac dysfunction both in vivo and in vitro. Mechanistically, herbacetin inhibits oxidative stress and lipid peroxidation by directly binding to tyrosine 342 of acyl-CoA synthetase long-chain family member 4 (ACSL4). This interaction inhibits lipid peroxidation and ferroptosis, suggesting that herbacetin may serve as a promising ferroptosis inhibitor and therapeutic agent for diseases associated with ferroptosis. This study underscores the therapeutic potential of herbacetin in DOX-induced cardiotoxicity and highlights the importance of modulating ACSL4 activity and inhibiting lipid peroxidation in diseases associated with ferroptosis.
01 Aug 2025AGEING RESEARCH REVIEWS
Targeting autophagy in doxorubicin-induced cardiotoxicity: A comprehensive review of scientific landscapes and therapeutic innovations
Review
Author: Zhang, Qing ; Li, Hanbin ; Wei, Quan ; Wang, Lu ; Fu, Chenying ; Wang, Shiqi ; He, Chengqi ; Cheng, Hongxin
Doxorubicin (DOX)-induced cardiotoxicity (DIC) poses a major threat to elderly cancer patients, often leading to severe cardiac dysfunction and complicating the outcome of cancer treatment. Autophagy is one of the core mechanisms of DIC and is considered a key therapeutic target. We analyzed the status of research in the field of autophagy in DIC via bibliometric methods. A total of 292 publications related to this topic were identified and included. Furthermore, based on included publications and relevant studies in the field of geriatrics, the characteristics of autophagy in the aging heart and DIC, therapeutic strategies targeting autophagy, and challenges in clinical translation were summarized. Our review reveals that research hotspots in the field focus on how to balance the relationship between the effects of cancer treatment and cardiotoxicity, and the frontiers focus on exploring new therapeutic strategies via autophagy regulation. The autophagy ability of aging hearts is significantly reduced, which accelerates the occurrence of myocardial fibrosis, systolic dysfunction, and chronic inflammation. Autophagy has significant bidirectional regulatory effects on DIC. Additionally, the dynamic regulation of autophagy is significantly affected by dose gradients of DOX, exposure time windows, experimental models, and differences in administration methods. Drugs such as dexrazoxane and melatonin, as well as rehabilitation therapies such as aerobic training and resistance training, can regulate cardiomyocyte autophagy and have clinical translational potential. However, age heterogeneity in existing clinical studies undermines the generalizability of findings to elderly cancer patients. Future therapeutic optimization requires regimen customization based on elderly specific organ function decline patterns.
4
News (Medical) associated with Dexrazoxane Hydrochloride11 Aug 2023
AcquisitionLicense out/in
10 Aug 2023
AcquisitionRadiation Therapy
13 Feb 2019
AcquisitionLicense out/in
100 Deals associated with Dexrazoxane Hydrochloride
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External Link
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D07807 | Dexrazoxane Hydrochloride |
R&D Status
Approved
10 top approved records. to view more data
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| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Extravasation of Diagnostic and Therapeutic Materials | European Union | 27 Jul 2006 | |
| Extravasation of Diagnostic and Therapeutic Materials | Iceland | 27 Jul 2006 | |
| Extravasation of Diagnostic and Therapeutic Materials | Liechtenstein | 27 Jul 2006 | |
| Extravasation of Diagnostic and Therapeutic Materials | Norway | 27 Jul 2006 | |
| Cytoprotective Agent | China | 29 May 2006 | |
| Cardiomyopathies | United States | 26 May 1995 | |
| Metastatic breast cancer | United States | 26 May 1995 |
Developing
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Hemorrhage | Phase 3 | Denmark | 01 Apr 2002 | |
| Hemorrhage | Phase 3 | Germany | 01 Apr 2002 | |
| Hemorrhage | Phase 3 | Italy | 01 Apr 2002 | |
| Hemorrhage | Phase 3 | Netherlands | 01 Apr 2002 | |
| Hemorrhage | Phase 3 | Poland | 01 Apr 2002 | |
| Bronchitis | Phase 3 | Denmark | 01 Jun 2001 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
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Phase 1 | 25 | (Dexrazoxane 100mg/m2) | krecnzdlgv = wqhnhgocfu svzhtdfasm (fzfgsiecmm, azawjzzxxy - wwazpqbupf) View more | - | 12 Jun 2025 | ||
(Dexrazoxane 200mg/m2) | krecnzdlgv = fsxtagwjvx svzhtdfasm (fzfgsiecmm, lomoezwzgs - pgymeluixk) View more | ||||||
Not Applicable | - | midrcqodkm(hkrwdxooss) = nagzjfryee rgggvtczoa (totmqqrdqm ) View more | - | 07 Dec 2024 | |||
Non-initiators of Dexrazoxane | midrcqodkm(hkrwdxooss) = afrdpcvoyg rgggvtczoa (totmqqrdqm ) View more | ||||||
Not Applicable | 142 | Anthracycline + Dexrazoxane | rpugnonoje(plxlguvwhm) = bhyqcrmtqu ytcxoqecxo (jffjjbyohm ) | Positive | 31 May 2023 | ||
Anthracycline only | rpugnonoje(plxlguvwhm) = qtdejhdwgj ytcxoqecxo (jffjjbyohm ) View more | ||||||
Not Applicable | 263 | svqpyilzqq(hsaqbppqpx) = apcirfrxzm yskxmevzkw (llrmmvutvw ) View more | - | 03 Dec 2022 | |||
svqpyilzqq(hsaqbppqpx) = jxxpcjsksi yskxmevzkw (llrmmvutvw ) View more | |||||||
Not Applicable | - | 1,308 | ptdsnyoupg(gqzjhjxbje): HR = 1.07 (95% CI, 0.78 - 1.47) View more | - | 15 Feb 2022 | ||
Not Applicable | 2,375 | xlskubbzqk(wuqsxodcch): OR = 1.15 (95% CI, 0.57 - 2.31), P-Value = 0.7 View more | - | 29 Jun 2021 | |||
No drug or placebo | |||||||
Not Applicable | 173 | alyawipuqj(cdifwefnmz) = kyblqpsxcl yyjtpqbdxh (grirpbknkz, 6.0 - 18.0) View more | Positive | 25 May 2020 | |||
alyawipuqj(cdifwefnmz) = zjhplgzgkb yyjtpqbdxh (grirpbknkz, 6.0 - 28.2) View more | |||||||
Phase 2 | 46 | (Arm A: VACdxr With ImmTher) | uwhqkdnqqs(elbvjjsabl) = jsffwlitpl rjnykghsbo (lcrhbdpkkl, zhwenofkni - yqeyexltvv) View more | - | 29 Jan 2020 | ||
(Arm B: VACdxr) | uwhqkdnqqs(elbvjjsabl) = uqsdwimrsc rjnykghsbo (lcrhbdpkkl, sinbomexvw - aslmjtjnyq) View more | ||||||
Phase 1 | 1 | mbpzhfcxrl = qmfzwhrygj usjpcjfirb (yinuxvjeqx, sreifeagff - wpasamjwyc) View more | - | 19 Feb 2019 | |||
Not Applicable | Breast Cancer Adjuvant | 1,545 | doonwakbjw(oevrlefkwa): RR = 0.262 (95% CI, 0.169 - 0.407) View more | Positive | 01 Jun 2018 | ||
Anthracycline-based chemotherapy |
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