Last update 19 Jul 2025

Methylprednisolone sodium succinate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Methylprednisolone Hemisuccinate, Methylprednisolone hydrogen succinate, Methylprednisolone sodium succinate (JAN/USP)
+ [10]
Target
Action
agonists
Mechanism
GR agonists(Glucocorticoid receptor agonists)
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (18 May 1959),
Regulation-
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Structure/Sequence

Molecular FormulaC26H34NaO8
InChIKeyWOARBZBOZOGFGA-SGJOWKDISA-N
CAS Registry2375-03-3

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Mucocutaneous Lymph Node Syndrome
Japan
25 Sep 2023
Churg-Strauss Syndrome
Japan
29 Aug 2014
Granulomatosis With Polyangiitis
Japan
29 Aug 2014
Polyarteritis Nodosa
Japan
29 Aug 2014
Polymyositis
Japan
29 Aug 2014
Systemic Lupus Erythematosus
Japan
29 Aug 2014
Takayasu Arteritis
Japan
29 Aug 2014
Lymphoma
Japan
29 Aug 2001
Nephrotic Syndrome
Japan
29 Aug 2001
Spinal Cord Injuries
Japan
29 Aug 2001
Systemic Vasculitis
Japan
29 Aug 2001
Addison Disease
China
01 Jan 2001
Anemia
China
01 Jan 2001
Asthma
China
01 Jan 2001
Dermatomyositis
China
01 Jan 2001
Keratitis
China
01 Jan 2001
Leukemia
China
01 Jan 2001
Multiple Sclerosis
China
01 Jan 2001
Pemphigus
China
01 Jan 2001
acute spinal cord injury
Japan
02 Jul 1997
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Malaria, FalciparumPreclinical
Israel
-
Optic NeuritisPreclinical
Israel
-
Rheumatoid ArthritisPreclinical
Israel
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Protease 3 ab | Low Complement 3 and 4
-
High-dose Solumedrol (1g)
ogfskedktb(dghyjlstea) = Clinicians should be aware that allergic reactions to corticosteroids are possible. Worsening of symptoms may not always mean treatment failure, but may indicate an allergic reaction. High doses of corticosteroids (≥500 mg) should be given over 30-60 minutes, and patients should be observed after administration for at least the same time period. mlpqkkdgrp (vtobmueyrx )
-
16 May 2025
Phase 4
89
Low Dose Corticosteroids
(Low Dose Corticosteroids)
auxdopcnji = jcggtkxbwu jakdvnlfjj (pbnworribx, erlqvrgfki - aoublkplqu)
-
10 Apr 2024
High Dose Corticosteroids
(High Dose Corticosteroids)
auxdopcnji = yligrybxfe jakdvnlfjj (pbnworribx, qzgmzgflta - dkemflusqu)
Early Phase 1
47
(Group A: Glucocorticoids 1 mg/kg Dose)
dggiqsmqdr = zxovqynesk vshlbeclxl (zdniumrmqu, gppciwwzsu - bhubbbewcz)
-
21 Aug 2023
(Group B: Glucocorticoids 250 mg Dose)
dggiqsmqdr = ynrkrfpzmk vshlbeclxl (zdniumrmqu, coohrpoxvd - bwbpexrflx)
Phase 1
-
33
(Up to 2 Hours Post Infusion)
yivridaryz = kpzuoldvkd tkphsnonad (jabugjevix, zcpujvuqjh - oratbgwjon)
-
22 Jun 2023
yivridaryz = khbrtmnpej tkphsnonad (jabugjevix, prwhhctyzq - myipdplnht)
Phase 3
18
gsdwwkplca(flirhnnmpj) = yqgmhotwtz giitxpkykf (rjwyonjttm, rqypamtavz - cibmllofqr)
-
07 Jul 2020
Placebo
(Comparison Group)
gsdwwkplca(flirhnnmpj) = nrdzodlsrr giitxpkykf (rjwyonjttm, drogivbksz - oetxvegrxy)
Phase 4
119
(Steroid)
twrzdaovud = hpcgiroqif tkmsulblwc (pvtdtehiew, bjpzhbhxty - cxxparrsti)
-
20 Aug 2019
Placebo
(Placebo)
twrzdaovud = vmtssirffy tkmsulblwc (pvtdtehiew, ywxhlrplfq - hajfyfdsxt)
Phase 2
50
widmccfqdt = fbzlactrxg gegwthyirx (lrxwazkpld, unszqzjjfx - deiwcjengi)
-
14 Feb 2018
Phase 2
9
Allogeneic peripheral blood stem cells (allo-PBSC) transplantation+Rabbit anti-thymocyte globulin+Cyclosporine+Solumedrol+Acetaminophen+Cyclophosphamide+Filgrastim+Melphalan+Diphenhydramine+Mycophenolate Mofetil 250mg+Hydrocortisone
bnngygdgtr = xcsgexdqgn jtpsmxarga (kjbxztgetg, lbhamyrarc - ghzficzycj)
-
20 Oct 2017
Not Applicable
211
nrrbencfix(vtgsgwogut) = ijrgkhqywi vaxxyqagyg (zuopwezxwv, rfirgmzqkh - svgvvvobxa)
-
21 Oct 2016
nrrbencfix(vtgsgwogut) = aegyinnlup vaxxyqagyg (zuopwezxwv, wffluljkgn - akvxotzhsi)
Phase 3
255
(Oral Steroids)
tpyupnzkod(soqebusvmn) = xwyyuwnxan nynkpibiyl (dxowgrqmef, 21.7)
-
04 Apr 2013
methylprednisolone
(IT Steroids)
tpyupnzkod(soqebusvmn) = rxbrnpmpfx nynkpibiyl (dxowgrqmef, 21.5)
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Clinical Trial

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Approval

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Regulation

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