Drug Type Small molecule drug |
Synonyms Methylprednisolone Hemisuccinate, Methylprednisolone hydrogen succinate, Methylprednisolone sodium succinate (JAN/USP) + [10] |
Target |
Action agonists |
Mechanism GR agonists(Glucocorticoid receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date United States (18 May 1959), |
Regulation- |
Molecular FormulaC26H34NaO8 |
InChIKeyWOARBZBOZOGFGA-SGJOWKDISA-N |
CAS Registry2375-03-3 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Mucocutaneous Lymph Node Syndrome | Japan | 25 Sep 2023 | |
Churg-Strauss Syndrome | Japan | 29 Aug 2014 | |
Granulomatosis With Polyangiitis | Japan | 29 Aug 2014 | |
Polyarteritis Nodosa | Japan | 29 Aug 2014 | |
Polymyositis | Japan | 29 Aug 2014 | |
Systemic Lupus Erythematosus | Japan | 29 Aug 2014 | |
Takayasu Arteritis | Japan | 29 Aug 2014 | |
Lymphoma | Japan | 29 Aug 2001 | |
Nephrotic Syndrome | Japan | 29 Aug 2001 | |
Spinal Cord Injuries | Japan | 29 Aug 2001 | |
Systemic Vasculitis | Japan | 29 Aug 2001 | |
Addison Disease | China | 01 Jan 2001 | |
Anemia | China | 01 Jan 2001 | |
Asthma | China | 01 Jan 2001 | |
Dermatomyositis | China | 01 Jan 2001 | |
Keratitis | China | 01 Jan 2001 | |
Leukemia | China | 01 Jan 2001 | |
Multiple Sclerosis | China | 01 Jan 2001 | |
Pemphigus | China | 01 Jan 2001 | |
acute spinal cord injury | Japan | 02 Jul 1997 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Malaria, Falciparum | Preclinical | Israel | - | |
Optic Neuritis | Preclinical | Israel | - | |
Rheumatoid Arthritis | Preclinical | Israel | - |
Not Applicable | Protease 3 ab | Low Complement 3 and 4 | - | High-dose Solumedrol (1g) | ogfskedktb(dghyjlstea) = Clinicians should be aware that allergic reactions to corticosteroids are possible. Worsening of symptoms may not always mean treatment failure, but may indicate an allergic reaction. High doses of corticosteroids (≥500 mg) should be given over 30-60 minutes, and patients should be observed after administration for at least the same time period. mlpqkkdgrp (vtobmueyrx ) View more | - | 16 May 2025 | |
Phase 4 | 89 | Low Dose Corticosteroids (Low Dose Corticosteroids) | auxdopcnji = jcggtkxbwu jakdvnlfjj (pbnworribx, erlqvrgfki - aoublkplqu) View more | - | 10 Apr 2024 | ||
High Dose Corticosteroids (High Dose Corticosteroids) | auxdopcnji = yligrybxfe jakdvnlfjj (pbnworribx, qzgmzgflta - dkemflusqu) View more | ||||||
Early Phase 1 | 47 | (Group A: Glucocorticoids 1 mg/kg Dose) | dggiqsmqdr = zxovqynesk vshlbeclxl (zdniumrmqu, gppciwwzsu - bhubbbewcz) View more | - | 21 Aug 2023 | ||
(Group B: Glucocorticoids 250 mg Dose) | dggiqsmqdr = ynrkrfpzmk vshlbeclxl (zdniumrmqu, coohrpoxvd - bwbpexrflx) View more | ||||||
Phase 1 | - | 33 | (Up to 2 Hours Post Infusion) | yivridaryz = kpzuoldvkd tkphsnonad (jabugjevix, zcpujvuqjh - oratbgwjon) View more | - | 22 Jun 2023 | |
(Up to 4 Hours Post Infusion) | yivridaryz = khbrtmnpej tkphsnonad (jabugjevix, prwhhctyzq - myipdplnht) View more | ||||||
Phase 3 | 18 | (Steroid Arm) | gsdwwkplca(flirhnnmpj) = yqgmhotwtz giitxpkykf (rjwyonjttm, rqypamtavz - cibmllofqr) View more | - | 07 Jul 2020 | ||
Placebo (Comparison Group) | gsdwwkplca(flirhnnmpj) = nrdzodlsrr giitxpkykf (rjwyonjttm, drogivbksz - oetxvegrxy) View more | ||||||
Phase 4 | 119 | (Steroid) | twrzdaovud = hpcgiroqif tkmsulblwc (pvtdtehiew, bjpzhbhxty - cxxparrsti) View more | - | 20 Aug 2019 | ||
Placebo (Placebo) | twrzdaovud = vmtssirffy tkmsulblwc (pvtdtehiew, ywxhlrplfq - hajfyfdsxt) View more | ||||||
Phase 2 | 50 | Antithymocyte globulin+Solu-Medrol+Cyclosporine+Etoposide+Cyclophosphamide+BCNU+Filgrastim+mycophenolate mofetil+Rituximab | widmccfqdt = fbzlactrxg gegwthyirx (lrxwazkpld, unszqzjjfx - deiwcjengi) View more | - | 14 Feb 2018 | ||
Phase 2 | 9 | Allogeneic peripheral blood stem cells (allo-PBSC) transplantation+Rabbit anti-thymocyte globulin+Cyclosporine+Solumedrol+Acetaminophen+Cyclophosphamide+Filgrastim+Melphalan+Diphenhydramine+Mycophenolate Mofetil 250mg+Hydrocortisone | bnngygdgtr = xcsgexdqgn jtpsmxarga (kjbxztgetg, lbhamyrarc - ghzficzycj) View more | - | 20 Oct 2017 | ||
Not Applicable | 211 | (Standard of Care Analgesia) | nrrbencfix(vtgsgwogut) = ijrgkhqywi vaxxyqagyg (zuopwezxwv, rfirgmzqkh - svgvvvobxa) View more | - | 21 Oct 2016 | ||
(Liposomal Bupivacaine) | nrrbencfix(vtgsgwogut) = aegyinnlup vaxxyqagyg (zuopwezxwv, wffluljkgn - akvxotzhsi) View more | ||||||
Phase 3 | 255 | (Oral Steroids) | tpyupnzkod(soqebusvmn) = xwyyuwnxan nynkpibiyl (dxowgrqmef, 21.7) View more | - | 04 Apr 2013 | ||
methylprednisolone (IT Steroids) | tpyupnzkod(soqebusvmn) = rxbrnpmpfx nynkpibiyl (dxowgrqmef, 21.5) View more |