Proton pumps are enzymes found in the stomach lining that play a crucial role in the production of gastric acid.

JAK inhibitors can inhibit JAK kinases, block the JAK-STAT signaling pathway, and have great therapeutic potential for a variety of diseases including tumors, immune & inflammation···

Monoamine Oxidase(MAO) is a naturally existing oxidase in the human body, located on the outer membrane of mitochondria.

ACE, or angiotensin-converting enzyme, plays a crucial role in the human body by regulating blood pressure and fluid balance.

SGLT2 inhibitors use a unique insulin-independent mechanism to lower blood glucose levels, not only effectively and safely reducing glucose, but also providing significant cardio-renal protection.

PCSK9 is a serine protease synthesized by the liver, which can bind to and degrade the low-density lipoprotein receptor (LDL-R), reducing LDL-R's clearance of low-density lipoprotein cholesterol (LDL-C) in the serum.

PARP inhibitors had once brought about a "decade breakthrough" for ovarian cancer, and in search for new areas of business growth, AZ is primarily seeking the approval for the use of olaparib in metastatic prostate cancer.

With KRAS, a previously considered untouchable target, being cracked open, the KRAS G12C inhibitors of Amgen and Mirati are now on the market. The question is, how can we further optimize treatment outcomes for patients?

Relaxin Family Peptide Receptor 1 (RXFP1) is the receptor of relaxin-2, and relaxin-2 is an important regulator of reproduction and cardiovascular physiology.

METTL3 is an RNA methyltransferase that catalyzes the methylation of RNA at N6-adenosine, making it a key player in this process.

The Y220C target mutation is a common oncogenic missense mutation, with a slightly lower mutation frequency compared to R249S and G245S located on the DNA binding surface.

PI3Kα is a crucial lipid kinase and one of the most frequently mutated kinases in cancer. It consists of a heterodimer composed of the catalytic subunit p110α and the regulatory subunit p85α.