JAK3 is a narrow-spectrum member that only regulates γc cytokines, thus becoming an ideal potential target.

Selinexor, a small molecule drug targeting XPO1, is developed by Karyopharm Therapeutics, Inc.

The recent launch of the Clinical Trial Result Database on the Synapse Database resolves the problems of data comprehensiveness and selection.

Lanifibranor, a small-molecule drug targeting PPARα + PPARγ + PPARδ, was initially developed by AbbVie, Inc.

This study first revealed that dexmedetomidine inhibits the microglial synaptic elimination process mediated by the complement C3-C3aR signaling pathway.

Brogidirsen is a drug targeting DMD exon 44 antisense oligonucleotide, developed by Nippon Shinyaku Co.

Synapse functions as an indispensable free drug pipeline database tool for pharmaceutical and biotech sectors, enhancing drug pipelines and marketed drugs by presenting analytical intelligence on a wide range of drug discovery and development.

Fruquintinib is a small molecule drug targeting VEGFR1, VEGFR2, and VEGFR3. This drug was initially developed by Hutchison Whampoa Medicine (Shanghai) Co., Ltd.

The study, titled "Netrin-1 blockade inhibits tumor growth and EMT features in endometrial cancer," presents compelling evidence of the efficacy of a novel anti-Netrin-1 antibody in reducing tumor progression and inhibiting epithelial-to-mesenchymal transition (EMT).

AMPK, which stands for AMP-activated protein kinase, is a key molecule in regulating energy metabolism and is at the core of research into diabetes and other metabolic-related diseases.

Anthrax Vaccine Adsorbed, Adjuvanted, com-mercially known as CYFENDUS, is a preventive vaccine targeting TLR9.

The cGAS-STING signaling pathway is a cytoplasmic DNA sensing pathway that plays a critical role in innate immune responses.