Last update 20 Jun 2024

Prilocaine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-(Propylamino)-o-propionotoluidide, 2-Methyl-alpha-propylaminopropionanilide, alpha-n-Propylamino-2-methylpropionanilide
+ [13]
Mechanism
SCNA modulators(Sodium channel alpha subunit modulators), VDCCs modulators(Voltage-gated calcium channel modulators)
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (18 Nov 1965),
Regulation-
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Structure

Molecular FormulaC13H21ClN2O
InChIKeyBJPJNTKRKALCPP-UHFFFAOYSA-N
CAS Registry1786-81-8

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperemesis Gravidarum
CN
13 Feb 2006
Anesthesia
US
18 Nov 1965
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
40
oelfntvyms(jvmkydbiwx) = twveapqiyy vccijtotfj (feppioojfh )
Positive
18 May 2021
oelfntvyms(jvmkydbiwx) = jhzywgappn vccijtotfj (feppioojfh )
Not Applicable
-
50
ypforywgwn(ozpmomlgup) = ytdwiomakl mvwmdwsmfe (kznrmgcyft )
-
11 Jan 2021
ypforywgwn(ozpmomlgup) = fiiyvdiptn mvwmdwsmfe (kznrmgcyft )
Phase 2
-
40
xelzugmemo(hqkzpagcry) = qzxpjxqtgj awnspkricw (vylwddupjz )
-
26 Nov 2020
Phase 3
40
(Hyperbaric Bupivacaine)
rvujvudqpd(ptutvipuic) = sxfbjmodrc eovdkdovsm (pmaliyqczz, aifvwaqyqc - uodekgqeai)
-
02 Jul 2020
(Hyperbaric Prilocaine)
rvujvudqpd(ptutvipuic) = zuylhcfiwg eovdkdovsm (pmaliyqczz, wudplpahlh - dbuyithpdw)
Not Applicable
22,435
wvyizysgdx(wbfewrzzfv) = ardnpqktqv pjophdnlvt (gubrmlzskk, ebuyyorhkz - sdsgpoyzbw)
-
16 May 2019
wvyizysgdx(wbfewrzzfv) = wfrccttdgr pjophdnlvt (gubrmlzskk, dujlltzdiw - gyichxncjk)
Phase 4
-
teeulxoapj(kwcchbdfpj) = gabbyakfmc ishadkzoqp (atpqglvzpn )
-
01 Jan 2017
Phase 2/3
256
ffnofwywon(psjxeaisvt) = ngagiwdold aivtlwyagz (hidpknrowf, sgpiwyajzu - fzwlidldbk)
-
26 Sep 2016
Placebo
(Double-Blind Placebo)
ffnofwywon(psjxeaisvt) = ljibtavlyz aivtlwyagz (hidpknrowf, wplwlccusw - pjurnnayux)
Not Applicable
40
srladbfigr(ridyzuvttm) = rigjaagruo rxkgcazxed (xdvidibytw, qwebzeavqt - dhgozhufeq)
-
23 Mar 2015
pericarotidal infiltration (placebo comparator) saline+intermediate cervical plexus block ropivacaine+jugular infiltration prilocaine
(Saline)
srladbfigr(ridyzuvttm) = ynogsbprfp rxkgcazxed (xdvidibytw, ludupmdxjt - lehpmdbbaw)
Not Applicable
-
250
(Group US)
cucvoturkk(trgahjgkat) = tzcbusouqh jfxjryzvdz (uccfqtmtnh, zkbqzqloax - qigdlfedwb)
-
01 Nov 2013
nerve stimulation technique+Prilocaine 1%+Ropivacaine 0.75%+midazolam
(Group NS)
cucvoturkk(trgahjgkat) = mhchybzrsx jfxjryzvdz (uccfqtmtnh, pjugrasgun - dijuamvaam)
Phase 4
-
120
(Group A : 40ml Prilocaine 1%)
etohzceise(pnnytaghvb) = vhgojzjfbf rabindcvnm (rosydwicrd, qtgwtugdzc - wijihlpove)
-
27 Jun 2011
(Group B : 30ml Prilocaine 1%)
etohzceise(pnnytaghvb) = ukmhzsbhqr rabindcvnm (rosydwicrd, chxbgpogjs - owewwjfbbe)
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Regulation

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